PPARγ Transcription Effect on Naturally Occurring
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            -Prenyl Cinnamaldehydes and Cinnamyl Alcohol Derivatives

Genovese, Salvatore; Epifano, Francesco; Rollinger, Judith M.; Fiorito, Serena

doi:10.4155/fmc-2021-0054

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…An interesting metabolite, cinnamyl alcohol, was found in the intestine in the HFDOR group. Long-term HFD feeding causes adipocyte hyperplasia[ 54 ]; however, cinnamyl alcohol inhibits adipocyte hyperplasia[ 55 ] and promotes lipid metabolism via the PPAR signalling pathway[ 56 ]. Hence, cinnamyl alcohol is considered a promising candidate for preventing and treating obesity.…”

Section: Discussionmentioning

confidence: 99%

Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis

Pang

Zheng

et al. 2022

Lipids Health Dis

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Background Although obesity is caused by different factors, individual susceptibility to obesity differs among people under the same circumstances. The microbiota in the caecum or fresh faeces and metabolites in blood or urine contribute to obesity resistance; however, the microbiota or metabolites in the small intestine have not been extensively studied. Methods To investigate the relationship between the microbiota or metabolites in the small intestine and susceptibility to obesity, eighty-eight male C57BL/6 mice were fed a high-fat diet (HFD) for 8 weeks to establish two models of obesity and obesity resistance. For further study, six mice were chosen from among the obesity models, and twelve mice were randomly chosen from among the obesity resistance models. After fasting plasma glucose and behavioural testing, the mice were fed in single cages for another 4 weeks to observe their weight and food intake. All mice were sacrificed at 20 weeks of age. Serum ALT, AST, HDL, LDL, TG and TC levels were measured using an automatic biochemical analyser. The microbiota and metabolites in the small intestine contents were analysed using 16 S sequencing and an ultrahigh-performance liquid chromatographic system, respectively. Transcripts in the jejunum were evaluated using full-length transcriptome sequencing and verified by qPCR. Results The results showed that HFD induced depression and anxiety behaviours and higher fasting plasma glucose, ALT, AST, HDL, LDL, TG and TC levels in the obese mice; however, these levels were improved in obese resistance mice. The correlation analysis showed that the phosphatidylcholine, TG, and phosphatidylethanolamine levels were higher in obese mice and correlated positively with intestinal microflora (Desulfovibrio and Gemella) and the Cxcl10 gene. A higher abundance of Clostridium_sensu_stricto_1 in obesity-resistant mice correlated negatively with the metabolite contents (neuromedin N and enkephalin L) and Pck1 gene expression and correlated positively with certain metabolites (5-hydroxy-L-tryptophan, cinnamyl alcohol and 1 H-indole-3-acetamide) and genes expression (Gdf15, Igfbp6 and Spp1). Conclusion Clostridium_sensu_stricto_1, neuromedin N, enkephalin L, Pck1, 5-hydroxy-L-tryptophan, Cxcl10 and cinnamyl alcohol may be novel biomarkers in the small intestine for obesity/obesity resistance. These might be helpful for obesity prevention or for treating obese patients.

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Section: Discussionmentioning

confidence: 99%

Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis

Pang

Zheng

et al. 2022

Lipids Health Dis

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“…In addition, cinnamic acid isolated from the hydro-alcohol extract of Cinnamomum cassia has been found to activate glucose transport in L6 myotubes through involvement of glucose transporter-4 via a phosphoinositide 3-kinase-independent pathway ( Sangeetha et al, 2017 ). In a related study, cinnamyl alcohols were found to interact with the peroxisome proliferator-activated receptor gamma receptor, which is a key regulator of the metabolism and storage of lipids and glucose ( Genovese et al, 2021 ). The studies mentioned above indicated that coumarin, cinnamic acid, and cinnamyl alcohol could have protective roles in DM, and our results provide more detailed explanations for these function.…”

Section: Discussionmentioning

confidence: 99%

Ethyl-acetate fraction from a cinnamon-cortex extract protects pancreatic β-cells from oxidative stress damage

Qiao²,

Lin³

et al. 2023

Front. Pharmacol.

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Background: The pathogenesis of diabetes mellitus is mediated mainly by oxidative stress produced by damaged pancreatic β-cells. We identified that an ethyl-acetate fraction (EA) from a cinnamon-cortex extract (CCE) is rich in flavonoid, and showed no toxicity to β cells.Objective: In this study, we evaluated the pharmacologic activities of EA on pancreatic β cells using a model of oxidative stress induced by H2O2 or alloxan.Results: The results showed that EA could significantly reduce reactive oxygen (ROS) accumulation to improve the survival of cells. Western blot showed that EA treatment upregulated expression of nuclear factor erythroid 2 related factor 2, heme oxygenase-1, and gamma glutamylcysteine synthetase. The same model study found that EA also can protect β cells against the apoptosis induced by oxidative stress. Furthermore, EA can enhance insulin secretion in rat and mouse β cell lines treated or not with alloxan or H2O2. The expression of the insulin transcription factor PDX-1 increased in an EA concentration-dependent manner. At last, the major functional compounds of EA analysis showed that three compounds, cinnamyl alcohol, coumarin, and cinnamic acid, had similar effects as EA.Conclusions: In sum, our data suggested that EA fraction from CCE can protect β cells from oxidative stress, and increase insulin secretion to improve the function of β cells. This function might be due to these three compounds found in EA. Our findings provide a theoretical basis and functional molecules for the use of CCE against diabetes mellitus.

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The Protective Effects of Cinnamyl Alcohol Against Hepatic Steatosis, Oxidative and Inflammatory Stress in Nonalcoholic Fatty Liver Disease Induced by Childhood Obesity

Dai,

Zhang,

et al. 2023

Immunological Investigations

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PPARγ Transcription Effect on Naturally Occurring O -Prenyl Cinnamaldehydes and Cinnamyl Alcohol Derivatives

Cited by 3 publications

References 24 publications

Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis

Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis

Ethyl-acetate fraction from a cinnamon-cortex extract protects pancreatic β-cells from oxidative stress damage

The Protective Effects of Cinnamyl Alcohol Against Hepatic Steatosis, Oxidative and Inflammatory Stress in Nonalcoholic Fatty Liver Disease Induced by Childhood Obesity

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