PPARγ regulates exocrine pancreas lipase

Danino, Hila; Naor, Ronny Peri; Fogel, Chen; Ben-Harosh, Yael; Kadir, Rotem; Salem, Hagit; Birk, Ruth

doi:10.1016/j.bbalip.2016.09.010

Cited by 7 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is possible to hypothesize that the increase of triglycerides excretion in feces caused by IHE could be due to its skill in reducing PPAR-γ expression and/or activity. In fact, as recently demonstrated, PPAR-γ transcriptionally up-regulates the gene expression of pancreatic triacylglycerol lipase [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…Further, the high-fat diet containing 1% IHE feeding rats had shown a reduction in blood triglyceride levels coupled with an increase in their feces excretion [ 32 ]. Pancreatic triacylglycerol lipase is known to be the main enzyme involved in the hydrolysis of dietary triglycerides in adults [ 43 ]. However, data from different in vitro investigations about IAA inhibitory effect of pancreatic triacylglycerol lipase are contradictory [ 29 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Promising Ability of Humulus lupulus L. Iso-α-acids vs. Diabetes, Inflammation, and Metabolic Syndrome: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

For centuries, natural medicines have represented the only option for treating human diseases and, nowadays, plant phytochemicals are considered as promising compounds to treat or prevent chronic conditions. Among them, hop flowers (Humulus lupulus L.), typically used in brewing industries to give the typical aroma and flavor to beer, have attracted particular attention for their health promoting properties. Several in vivo/vitro studies and human interventional trials have demonstrated the beneficial effects of these molecules on weight gain, lipid metabolism, glucose homeostasis, insulin sensitivities, and inflammation by acting on different targets. All these activities suggest a possible role of bitter hop acid in preventing metabolic syndrome and its related diseases. A systematic quest on PubMed and Scopus databases was performed to identify pre-clinical and clinical studies focusing on this topic. This systematic review summarizes the results obtained by different cell lines, animal models, and human interventional trials to propose iso-α-acids as medical nutrition therapy to treat or prevent metabolic syndrome and its related disorders as diabetes, dislipidemia inflammation, etc.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Promising Ability of Humulus lupulus L. Iso-α-acids vs. Diabetes, Inflammation, and Metabolic Syndrome: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition, PPAR‐γ can regulate pancreatic lipase, which is essential for hydrolyzing polyunsaturated fatty acids (PUFAs) …”

Section: Natural Ligands Of Ppar‐γ and Their Rolesmentioning

confidence: 99%

“…37 In addition, PPAR-γ can regulate pancreatic lipase, which is essential for hydrolyzing polyunsaturated fatty acids (PUFAs). 38 Benjamin et al have identified a class of LA, which is synthesized in the rumen of cattle and is termed as conjugated linoleic acid (CLA). The studies have revealed that CLA can inhibit colon carcinogenesis by enhancing PPAR-γ expression.…”

Section: Peroxisome Proliferator-activated Receptor γmentioning

confidence: 99%

PPAR‐γ: Its ligand and its regulation by microRNAs

Seiri

Abi

Soukhtanloo

2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR-γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. It has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancers. Among various cellular and molecular targets that are able to regulate PPAR-γ and its underlying pathways, microRNAs

show abstract

“…Protein engineering purposes, especially in enzymes, is enlarging the active position, changes activity (change specific activity, change the characteristics of the substrate), sustainability (change thermal stability, protease stability and oxidation stability) and resistance to surfactants and detergents [14][15][16]. Schmidt and colleagues also used random mutation by errorprone, created a set of mutations for target enzyme to change anantio selectioiti [13].…”

Section: Introductionmentioning

confidence: 99%

The Role of Protein Engineering in the Design and Production of Recombinant Proteins

Nejad

Niri

Fazilati

et al. 2016

IJVV

View full text Add to dashboard Cite

Proteins possess many structural and functional characteristics that these features are not seen in any other biomolecules. So many biologists have been persuaded that using protein engineering design and build their desired proteins. These engineered proteins can act as new molecular tools for scientific, medical, industrial, etc. applications, so they can satisfy many human needs that are not met by natural proteins. Protein engineering based on calculations Strategy produces and screens the protein sequences with "in silico" (i.e. before its synthesis in the laboratory). Structure-based protein engineering calculations similarly use the calculations to discover the protein sequences. However, calculation-based protein engineering also emphasizes the new and useful protein engineering and investigating the relationship between structure and function of them. This study investigates the protein engineering tools in producing the recombinant and engineered proteins. For this purpose, bioinformatics studies, how to predict the second and third buildings based on homology and adaptive modeling, predicting protein performance for the production of recombinant proteins are investigated.

show abstract

PPARγ regulates exocrine pancreas lipase

Cited by 7 publications

References 33 publications

The Promising Ability of Humulus lupulus L. Iso-α-acids vs. Diabetes, Inflammation, and Metabolic Syndrome: A Systematic Review

The Promising Ability of Humulus lupulus L. Iso-α-acids vs. Diabetes, Inflammation, and Metabolic Syndrome: A Systematic Review

PPAR‐γ: Its ligand and its regulation by microRNAs

The Role of Protein Engineering in the Design and Production of Recombinant Proteins

Contact Info

Product

Resources

About