PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis

Yu, Qiang; Cheng, Ping; Wu, Jianye; Guo, Chuanyong

doi:10.1111/jcmm.16267

Cited by 43 publications

(23 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, THP inhibits lipid accumulation and decreases the level or activity of lipid droplets, triglyceride, and glycerol-3-phosphate dehydrogenase in 3T3-L1 adipocytes through the AMPK signaling pathway ( Piao et al, 2017 ). THP inhibits extracellular matrix (ECM) deposition and hepatic stellate cells (HSCs) autophagy by regulating the PPAR gamma/NF-κB and TGF-beta 1/Smad pathways, thereby reducing liver fibrosis, which is a necessary stage in the progression of chronic liver disease to cirrhosis ( Yu et al, 2021 ) ( Figure 7 ). Other studies demonstrated that THP has a certain resistance to plasmodium( Baghdikian et al, 2013 ; Bory et al, 2013 ; Malebo et al, 2013 ), parasites ( Dutta et al, 2016 ), and pathogenic fungi ( Zhao et al, 2019 ).…”

Section: Pharmacological Activities Of Tetrahydropalmatinementioning

confidence: 99%

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

Meng

Wang

2022

Front. Pharmacol.

View full text Add to dashboard Cite

Tetrahydropalmatine (THP), a tetrahydroproberine isoquinoline alkaloid, is widely present in some botanical drugs, such as Stephania epigaea H.S. Lo (Menispermaceae; Radix stephaniae epigaeae), Corydalis yanhusuo (Y.H.Chou & Chun C.Hsu) W.T. Wang ex Z.Y. Su and C.Y. Wu (Papaveraceae; Corydalis rhizoma), and Phellodendron chinense C.K.Schneid (Berberidaceae; Phellodendri chinensis cortex). THP has attracted considerable attention because of its diverse pharmacological activities. In this review, the chemical properties, plant sources, pharmacological activities, pharmacokinetic and toxicological characteristics of THP were systematically summarized for the first time. The results indicated that THP mainly existed in Papaveraceae and Menispermaceae families. Its pharmacological activities include anti-addiction, anti-inflammatory, analgesic, neuroprotective, and antitumor effects. Pharmacokinetic studies showed that THP was inadequately absorbed in the intestine and had rapid clearance and low bioavailability in vivo, as well as self-microemulsifying drug delivery systems, which could increase the absorption level and absorption rate of THP and improve its bioavailability. In addition, THP may have potential cardiac and neurological toxicity, but toxicity studies of THP are limited, especially its long-duration and acute toxicity tests. In summary, THP, as a natural alkaloid, has application prospects and potential development value, which is promising to be a novel drug for the treatment of pain, inflammation, and other related diseases. Further research on its potential target, molecular mechanism, toxicity, and oral utilization should need to be strengthened in the future.

show abstract

Section: Pharmacological Activities Of Tetrahydropalmatinementioning

confidence: 99%

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

Meng

Wang

2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“… 56 Furthermore, the upregulation of HK2 and the enhancement of glycolysis have been reported to play pertinent roles in the activation of HSCs and liver fibrosis, 13 , 58 which is the main contributor to liver cirrhosis and HCC. 59 These findings show that targeting HK2 could be an excellent and safe strategy for treating HCC, even in the early phase of hepatocellular carcinogenesis. HK2 binds to VDAC1 on the outer mitochondrial membrane via its hydrophobic N terminal, which augments ATP production and promotes the proliferation of the HCC cells.…”

Section: Discussionmentioning

confidence: 84%

Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway

Dai

et al. 2022

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

Aerobic glycolysis is a well-known hallmark of hepatocellular carcinoma (HCC). Hence, targeting the key enzymes of this pathway is considered a novel approach to HCC treatment. The effects of sodium butyrate (NaBu), a sodium salt of the short-chain fatty acid butyrate, on aerobic glycolysis in HCC cells and the underlying mechanism are unknown. In the present study, data obtained from cell lines with mouse xenograft model revealed that NaBu inhibited aerobic glycolysis in the HCC cells in vivo and in vitro. NaBu induced apoptosis while inhibiting the proliferation of the HCC cells in vivo and in vitro. Furthermore, the compound inhibited the release of lactate and glucose consumption in the HCC cells in vitro and inhibited the production of lactate in vivo. The modulatory effects of NaBu on glycolysis, proliferation and apoptosis were related to its modulation of hexokinase 2 (HK2). NaBu downregulated HK2 expression via c-myc signalling. The upregulation of glycolysis in the HCC cells induced by sorafenib was impeded by NaBu, thereby enhancing the anti-HCC effect of sorafenib in vitro and in vivo. Thus, NaBu inhibits the expression of HK2 to downregulate aerobic glycolysis and the proliferation of HCC cells and induces their apoptosis via the c-myc pathway.

show abstract

“…During this study, the PPAR signaling pathway was the most important KEGG pathway in the Metascape database, which also has been found in several other cancer types. 88 , 89 , 90 , 91 , 92 , 93 , 94 …”

Section: Discussionmentioning

confidence: 99%

Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma

Zhang

Shi

Liu

et al. 2021

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) remains an extremely lethal disease worldwide. High-throughput methods have revealed global transcriptome dysregulation; however, a comprehensive investigation of the complexity and behavioral characteristics of the competing endogenous RNA (ceRNA) network in HCC is lacking. In this study, we extracted the transcriptome (RNA) sequencing data of 371 HCC patients from The Cancer Genome Atlas platform. With the comparison of the high Myc expression (Myc high ) tumor and low Myc expression (Myc low ) tumor groups in HCC, we identified 1,125 differentially expressed (DE) mRNAs, 589 long non-coding RNAs (lncRNAs), and 93 microRNAs (miRNAs). DE RNAs predicted the interactions necessary to construct an associated Myc ceRNA network, including 19 DE lncRNAs, 5 miRNAs, and 72 mRNAs. We identified a significant signature (long intergenic non-protein-coding [LINC] RNA 2691 [LINC02691] and LINC02499) that effectively predicted overall survival and had protective effects. The target genes of microRNA (miR)-212-3p predicted to intersect with DE mRNAs included SEC14-like protein 2 (SEC14L2) and solute carrier family 6 member 1 (SLC6A1), which were strongly correlated with survival and prognosis. With the use of the lncRNA-miRNA-mRNA axis, we constructed a ceRNA network containing four lncRNAs (LINC02691, LINC02499, LINC01354, and NAV2 antisense RNA 4), one miRNA (miR-212-3p), and two mRNAs (SEC14L2 and SLC6A1). Overall, we successfully constructed a mutually regulated ceRNA network and identified potential precision-targeted therapies and prognostic biomarkers.

show abstract

PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis

Cited by 43 publications

References 59 publications

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway

Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma

Contact Info

Product

Resources

About