PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways

Camps, Jordi; García-Heredia, Anabel; Rull, Anna; Alonso-Villaverde, Carlos; Aragonès, Gerard; Beltrán‐Debón, Raúl; Rodríguez-Gallego, Esther; Joven, Jorge

doi:10.1155/2012/616371

Cited by 46 publications

(45 citation statements)

References 89 publications

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“…Several experiments have shown PON1 to have a protective function in atherosclerosis (Mackness et al 2004, Camps et al 2012. In this process modifications of lipoproteins, such as oxidation, might lead to foam cell formation crucial for lipid plaque development (Fig.…”

Section: Pon1 Changes In Different Diseasesmentioning

confidence: 99%

A review of paraoxonase 1 properties and diagnostic applications

Kulka¹

2016

Polish Journal of Veterinary Sciences

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Paraoxonase 1 (PON1) is an arylesterase associated with serum high density lipoprotein particles. Its name is derived from hydrolyzing one of several organophosphate compounds, namely paraoxon. Recent studies have shown that PON1 plays a protective role in diseases associated with oxidative stress such as atherosclerosis and diabetes mellitus. Studies have demonstrated reduction-oxidative state changes involving PON1 in humans and laboratory animal models. Although there is less information about the role of this enzyme in veterinary medicine, new data suggest that PON1 might be a new oxidative stress marker in animal patients, similarly to humans.

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Section: Pon1 Changes In Different Diseasesmentioning

confidence: 99%

A review of paraoxonase 1 properties and diagnostic applications

Kulka¹

2016

Polish Journal of Veterinary Sciences

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“…Thus, it can not only detoxify several organophosphorus insecticides and nerve agents to protect against xenobiotic toxicity, but it can also inhibit LDL oxidation and increase macrophage-associated cholesterol efflux. It also possesses antioxidant, anti-inflammatory, and anti-atherogenic properties (13,15,16,17). Recent studies have shown that the physiological roles of PON1 are related to its lactonase and HTase activities.…”

Section: Introductionmentioning

confidence: 99%

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Zhang

Liu

et al. 2015

European Journal of Endocrinology

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Objective: To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS). Design: A case-control study. Methods: A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase:DEPCyMCase activity. The PON1 genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed. Results: The lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The K108C/T variation of the PON1 gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CCOCTOTT); the 192Q/R variation of the PON1 gene showed increased PON1 lactonase activities and NLA; and the 55L/M variation of the PON1 gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the K108C/T, 192Q/R, and 55L/M variations of the PON1 gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA. Conclusions: The serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the K108C/T, 192Q/R, and 55L/M genetic polymorphisms of PON1 may be associated with these changes.

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“…PPARγ-mediated activation of Nrf2 signaling, results in Nrf2-dependent inhibition of pro-inflammatory pathways. 40 In addition, PPARγ and Nrf2 are connected by a positive feedback loop that confirms the expression of both transcription factors and antioxidant. All at once, the two genes utilize a powerful anti-inflammatory action preventing the NF-κB pathway.…”

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confidence: 96%

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

Fahmy¹,

Azim²,

Gharib³

2016

IJPER

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Cisplatin (CP) and/ or radiation exposures cause oxidative stress, which induced liver toxicity. The present study was undertaken to explore if fish oil (FO) and /or selenium nano particles (SeNPs) can minimize CP-induced hepatotoxicity and other side effects. Rats were either treated with SeNPs (0.5 mg/kg) and /or FO (2 mg/Kg) for 12 days before treatment with CP (10 mg/Kg) and/ or exposure to γ-rays (0.7Gy).The results of the present study revealed that rats treated with CP and /or γ-radiation showed an increase in the level of IL6, renin and the expression of angiotensinogen , xanthine oxidase (XO) and NF-κB protein along with a decrease in (Nrf2) protein expression as well as, the activity of antioxidant enzymes. Fish oil and /or selenium nanoparticles (SeNPs) treatment prior to CP and/ or radiation exposure normalized these parameters. Our findings suggest that FO together with SeNPs could be used as protective supplements against toxicity associated with ionizing radiation and CP due to its antioxidant, anti-inflammatory and anti-apoptotic properties.

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PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways

Cited by 46 publications

References 89 publications

A review of paraoxonase 1 properties and diagnostic applications

A review of paraoxonase 1 properties and diagnostic applications

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

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