PPARs in Irradiation-Induced Gastrointestinal Toxicity

Linard, Christine; Souidi, Maâmar

doi:10.1155/2010/528327

Cited by 5 publications

(4 citation statements)

References 109 publications

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“…Peroxisome proliferator-activated receptor γ (PPAR γ ) is a nuclear receptor highly expressed in the intestines and plays a key role in inflammation. Further studies should explore the effects of abdominal irradiation on PPARs, their roles and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Bojungikki‐Tang against Radiation‐Induced Intestinal Injury in Mice: Experimental Verification and Compound‐Target Prediction

Kang

Lee

Nam

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Bojungikki-tang (BJIT) is a traditional herbal medicine used in Korea, Japan, and China to treat gastrointestinal disorders. In this study, we aimed to investigate whether BJIT has protective effects against radiation-induced intestinal injury and to predict the underlying therapeutic mechanisms and related pathways via network pharmacological analyses. BJIT was injected intraperitoneally (50 mg/kg body weight) to C3H/HeN mice at 36 and 12 h before exposure to partial abdominal irradiation (5 Gy and 13 Gy) to evaluate the apoptotic changes and the histological changes and variations in inflammatory cytokine mRNA levels in the jejunum, respectively. Through in silico network analysis, we predicted the mechanisms underlying BJIT-mediated regulation of radiation-induced intestinal injury. BJIT reduced the level of apoptosis in the jejunal crypts 12 h post 5-Gy irradiation. Histological assessment revealed intestinal morphological changes in irradiated mice 3.5 days post 13-Gy irradiation. Furthermore, BJIT decreased inflammatory cytokine levels following radiation exposure. Apoptosis, TNF, p53, VEGF, toll-like receptor, PPAR, PI3K-Akt, and MAPK signaling pathways, as well as inflammatory bowel disease (IBD), were found to be linked to the radioprotective effects of BJIT against intestinal injury. According to our results, BJIT exerted its potential protective effects by attenuating histopathological changes in jejunal crypts and suppressing inflammatory mediator levels. Therefore, BJIT is a potential therapeutic agent that can treat radiation-induced intestinal injury and its associated symptoms.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Bojungikki‐Tang against Radiation‐Induced Intestinal Injury in Mice: Experimental Verification and Compound‐Target Prediction

Kang

Lee

Nam

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Acute effects start from the second week onward and peak by the fourth to fifth week. 9 There are only few articles where feasibility of either radiation alone or chemoradiation is well studied in rural population. In a study by Jain et al, 10 on outcome of patients treated with radical radiotherapy alone in cervical carcinoma in a rural center in India, they did not come across any significant acute toxicities.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Concurrent Chemoradiation in Cervical Cancer Patients From Rural Background

Harjani

Janaki

Somashekhar

et al. 2014

Clinical Ovarian and Other Gynecologic Cancer

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There is paucity of literature about tolerability of standard chemoradiation in cervical cancer patients of rural background; hence, we undertook this study. Enteritis and dyselectrolytemias were the most common toxicities and the key reasons for radiation interruption and suboptimal chemotherapy doses. Nutritional and social support along with vigorous assessment for dyselectrolytemias and timely management is the key to optimizing treatment. Background: Concurrent chemoradiation causes toxicities such as enteritis, hematologic toxicities which may lead to treatment interruptions, and therefore inferior outcomes. Adequate supportive care is very important to complete the scheduled protocol. Most of our patients are from rural background with a heterogeneous social background (nutrition and social support). There is paucity of literature to evaluate the tolerance of this intense treatment in these groups of patients, and hence, this study was undertaken. Methods: In this observational study, 30 rural women having carcinoma cervix treated with concurrent chemoradiation between January and July 2013 were reviewed retrospectively. They were assessed weekly for dyselectrolytemia, enteritis, and hematologic toxicity using Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria. Treatment gaps along with reasons were recorded and correlated. Results: Median age of patients was 54 years. Of the patients, 43.3% were International Federation of Gynecology and Obstetrics stage II and 46.7% stage III. Grade 3 enteritis was seen in 7 of 30 patients (23.3%). None (0%) had grade 3 or higher hematologic toxicity. Dyselectrolytemiaehyponatremia (46.66%), hypokalemia (26.66%), hypocalcemia (6.66%), and hypomagnesemia (10%) were noted. Two of thirty patients (6.66%) received the planned 5 cycles, cisplatin 40 mg/m 2 weekly. There were treatment interruptions in radiation in 6 (20%) and treatment delays in chemotherapy in 10 (33.33%) patients. Conclusion: Concurrent chemoradiation for patients from rural areas is associated with higher acute toxicities. Regular monitoring for enteritis and dyselectrolytemias and timely intervention can help improve compliance and decrease treatment interruptions and thereby achieve the optimum treatment outcome.

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“…PCa pharmaceuticals were defined as those that are currently approved on the PBS for the treatment of PCa and related indications. General pharmaceuticals were included if they were considered to be related to the diagnosis of PCa, treatment of PCa or PCa disease or treatment side effects . PCa medical services were defined using PCa relevant MBS item numbers in combination with the MBS descriptor “provider specialty.” PCa‐specific provider specialties included medical oncology, diagnostic radiology, immunology, urology and radiation oncology.…”

Section: Methodsmentioning

confidence: 99%

Long-term health care costs for patients with prostate cancer: a population-wide longitudinal study in New South Wales, Australia

Cronin

Kirkbride

Bang

et al. 2016

Asia-Pac J Clin Oncol

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PPARs in Irradiation-Induced Gastrointestinal Toxicity

Cited by 5 publications

References 109 publications

Protective Effect of Bojungikki‐Tang against Radiation‐Induced Intestinal Injury in Mice: Experimental Verification and Compound‐Target Prediction

Protective Effect of Bojungikki‐Tang against Radiation‐Induced Intestinal Injury in Mice: Experimental Verification and Compound‐Target Prediction

Feasibility of Concurrent Chemoradiation in Cervical Cancer Patients From Rural Background

Long-term health care costs for patients with prostate cancer: a population-wide longitudinal study in New South Wales, Australia

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