PPARGC1A gene polymorphism is associated with exercise-induced fat loss

Abstract

BACKGROUNDːObesity is a widespread problem within modern society, serving to increase the risk of cardiovascular, metabolic, and neurodegenerative disorders. Peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator 1 α (PGC1α) play a key role in the regulation of cellular energy metabolism and is implicated in the pathology of these diseases. This study examined the association between polymorphisms of the PPARG and PPARGC1A genes and individual variability in weight loss in response to physical activity intervention. METHODS AND RESULTSːThirty-nine obese Ukrainian women (44.4 ± 7.5 years, BMI > 30.0 kg/m 2 ) undertook a 3-month fitness program whilst following a hypocaloric diet (~1500 calories). Anthropometric and biochemical measurements took place before and after the program. Single nucleotide polymorphisms within or near PPARG (n=94) and PPARGC1A (n=138) were identified and expression of PPARG mRNA was measured via reverse transcription and amplification. The association between DNA polymorphisms and exercise-induced weight loss, initial body mass, biochemistry and PPARG expression was determined using one-way analysis of variance (ANOVA).The present intervention induced significant fat loss in all participants (total fat: 40.3±5.3 vs 36.4±5.7%; P<0.00001). Only one polymorphism (rs17650401 C/T) within the PPARGC1A gene was found to be associated with fat loss efficiency after correction for multiple testing, with T allele carriers showing the greatest reduction in body fat percentage (2.5-fold; P=0.00013) compared to non-carriers. CONCLUSIONSː PPARGC1A (rs17650401) is associated with fat loss efficiency of the fitness program in obese women. Further studies are warranted to test whether this variation is associated with fat oxidation.

Association of gene polymorphisms with body weight changes in prediabetic patients

“…Furthermore, in DPP and the study of Frank et al, the PPARG rs1801282 G allele was associated with the short-term (up to 6 months) and long-term (up to 2 years) maintenance of achieved weight loss [34,45]. We suggest that the resistance of G allele carriers to changes in body weight may be explained by the fact that the presence of this allele is associated with a decrease in the transcriptional activity of PPARγ [46,47]. In this case, the PPARG rs1801282 C allele is associated with an increase in the transcriptional activity of PPARγ, which in turn leads to an increase in the sensitivity of cells to the action of insulin [48], promoting weight loss among patients.…”

Association of gene polymorphisms with body weight changes in prediabetic patients

“…Furthermore, in DPP and the study of Frank et al, the G allele of rs1801282 PPARG was associated with the short-term (up to 6 months) and long-term (up to 2 years) maintenance of achieved weight loss [32,43]. We suggest that the resistance of G allele carriers to changes in body weight may be explained by the fact that the presence of this allele is associated with a decrease in the transcriptional activity of PPARγ [44,45]. In this case, the С allele of rs1801282 PPARG is associated with an increase in the transcriptional activity of PPARγ, which in turn leads to an increase in the sensitivity of cells to the action of insulin [46], promoting weight loss among patients.…”

Особливості Мотиваційного Та Психічного Станів Жінок Другого Періоду Зрілого Віку З Надлишковою Масою Тіла

“…У наукових дослідженнях широко представлено тему побудови профілактично-оздоровчих занять для осіб зрілого віку, в тому числі і жінок другого періоду зрілого віку [9,16,18], розглянуто проблему надлишкової маси тіла [12,17]. Проте питання вивчення особливостей мотиваційного та психічного станів жінок другого періоду зрілого віку з надлишковою масою тіла залишається відкритим, а проєктування профілактично-оздоровчих занять з урахуванням цього фактора -перспективним для досліджень.…”