PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome
Sharmilee Vetrivel,
Mariangela Tamburello,
Andrea Oßwald
et al.
Abstract:BackgroundWe performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing’s syndrome (CS) to define areas of dysregulated and druggable targets.MethodologyNext-generation sequencing was performed on adrenal samples of patients with primary bilateral macronodular adrenal hyperplasia (PBMAH, n=10) and control adrenal samples (n=8). The validation groups included cortisol-producing adenoma (CPA, n=9) and samples from patients undergoing bilateral adrenalectomy for Cushi… Show more
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