PPAR gamma gene – A review

Janani, C.; Kumari, B. D. Ranjitha

doi:10.1016/j.dsx.2014.09.015

Cited by 547 publications

(424 citation statements)

References 67 publications

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“…To date, three subtypes of these receptors, encoded by distinct genes, have been described as PPARa, PPARb (named also PPARd) and PPARg [1][2][3]. Moreover, three variants of PPARg, created by alternative promoter usage and splicing, have been characterized as g1, g2 and g3 [4].…”

Section: Introductionmentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

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Section: Introductionmentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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“…There are 3 subtypes of PPARs encoded by distinct genes: α, β/δ, and γ ( Figure 1). PPARγ (PPARg) acts as a mediator of the link between lipid and glucose metabolism (17). Accordingly, PPARg agonists have been used in the treatment of dyslipidemia and hyperglycemia (18).…”

Section: Introductionmentioning

confidence: 99%

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Anghebem-Oliveira

Martins

Alberton

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods: 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age. The polymorphisms were genotyped using fluorescent probes (TaqMan ® ). Results: All groups were in Hardy-Weinberg equilibrium. The genotype and allele frequencies of the studied polymorphisms did not show significant differences between the groups (P > 0.05). In the healthy and GDM groups, the C allele frequencies (95% CI) of the FTO rs1421085 polymorphism were 36.8% [31-43%]

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“…Also, TZDs which are strong insulin sensitizers' drugs, act via PPARγ agonism [13,14]. Besides TZDs ben ficial effects in diabetes there are some deteriorating effects following TZDs administration which include hepatotoxicity and hepatic failure [25].…”

Section: T a B L E 2 Body Weight Glucose Insulin And Adiponectin mentioning

confidence: 99%

“…Anti-diabetic drugs, thiazolidinediones (TZDs), activate peroxisome proliferator-activated receptor-gamma (PPARγ) and consequently increase insulin sensitivity. PPARγ activation promotes insulin sensitivity and improves insulin receptor signaling in diabetes [13,14]. TZDs may affect insulin sensitivity by AMPK activation [12].…”

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confidence: 99%

Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver

Shahouzehi¹,

Barkhordari²,

Aminizadeh³

et al. 2017

Ukr.Biochem.J.

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PPAR gamma gene – A review

Cited by 547 publications

References 67 publications

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver

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