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Tosetti, Cesare; Stanghellini, Vincenzo; Tucci, Antonio; Poli, Loris; Salvioli, Beatrice; Biasco, Guido; Paparo, G. F.; Levorato, Maurizio; Corinaldesi, Roberto

doi:10.1023/a:1005439905134

Cited by 29 publications

(8 citation statements)

References 22 publications

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“…This poses the possibility that most of the previous scintigraphic studies have so far missed the initial rapid emptying elicited by gastric acid suppression. One scintigraphic study has suggested an association between altered gastric emptying and gastric hypoacidity; after ingestion of a mixed solid-liquid meal, the lag period was shorter and the subsequent emptying was slower in dyspeptic patients with achlorhydria than in those with reserved acid secretion [20]. These results support our speculation that gastric hypoacidity initially enhances and subsequently suppresses gastric emptying of solid meals.…”

Section: Discussionsupporting

confidence: 80%

“…Our data show that rabeprazole modestly elevated the fasting serum gastrin levels. Previous authors documented an inverse correlation between serum gastrin concentrations and rates of the post-lag gastric emptying based on a wide range of gastrin levels (up to 1,200 pg/ml), but the correlation was very weak [20]. In our study, hypergastrinemia might play a role in delaying the later (post-lag) phase of gastric emptying, but we think that this role is merely minor.…”

Section: Discussioncontrasting

confidence: 58%

“…It is, therefore, uncertain whether the rabeprazole-elicited enhancement of the initial emptying reflects the shortened lag phase. There are conflicting results on the effect of gastric hypoacidity on the lag period [9, 20]. …”

Section: Discussionmentioning

confidence: 99%

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Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Anjiki¹,

Sanaka²,

Kawakami³

2005

Digestion

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Background/Aims: Knowledge is limited regarding the effects of rabeprazole on gastric emptying. This randomized, open, crossover study was undertaken to investigate the effects. Methods: In 24 healthy volunteers (13 men and 11 women, aged 22–53 years), solid emptying was assessed twice using the ¹³C-octanoate breath test. On one occasion, the subjects received 20 mg rabeprazole for the preceding 2 days and 1 h before the test. On another occasion, they underwent no pretreatment. The time course of cumulative recovery of ¹³CO₂ in breath was fitted to z(t) = m(1 – e^–kt)^β^–1, and regression constants of k and β were determined. The half ¹³CO₂ excretion time (t_½b) and the time of maximal excretion (t_max) were calculated. Under the crossover protocol, k and β can describe the emptying features more precisely; a larger (smaller) β indicates a slower (faster) emptying in the early phase, and a larger (smaller) k indicates a faster (slower) emptying in the later phase. Between the two occasions, k, β, t_½b, and t_max were compared. Results: Rabeprazole significantly decreased k and β, significantly prolonged t_½b, but t_max remained unchanged. Conclusion: Rabeprazole has dual effects on solid emptying: an initial acceleration with a subsequent deceleration, resulting in an overall delay.

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Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 58%

See 1 more Smart Citation

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Anjiki¹,

Sanaka²,

Kawakami³

2005

Digestion

View full text Add to dashboard Cite

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“…Previously, in atrophic gastritis, a role of gastric emptying has been investigated, showing a delayed emptying both in the autoimmune [28] and nonautoimmune atrophic gastritis. [29] In addition, the reduced gastric acid secretion seems to be associated with the presence of dyspepsia [30] and more recently, a Japanese study conducted on dyspeptic outpatients showed that hypochlorhydria was significantly associated with higher dyspeptic symptom scores and dysmotility-related scores, in particular, in female. [31] …”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal symptoms in autoimmune gastritis

et al. 2017

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Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features.Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria. Association between symptoms and anemia pattern, positivity to gastric autoantibodies, Helicobacter pylori infection, and concomitant autoimmune disease were evaluated.In total, 70.2% of patients were female, median age 55 years (range 17–83). Pernicious anemia (53.6%), iron deficiency anemia (34.8%), gastric autoantibodies (68.8%), and autoimmune disorders (41.7%) were present. However, 56.7% of patients complained of gastrointestinal symptoms, 69.8% of them had exclusively upper symptoms, 15.8% only lower and 14.4% concomitant upper and lower symptoms. Dyspepsia, subtype postprandial distress syndrome was the most represented, being present in 60.2% of symptomatic patients. Univariate and multivariate analyses showed that age <55 years (OR 1.6 [CI:1–2.5]), absence of smoking habit (OR 2.2 [CI:1.2–4]), and absence of anemia (OR 3.1 [CI:1.5–6.4]) were independent factors associated to dyspepsia.Autoimmune gastritis is associated in almost 60% of cases with gastrointestinal symptoms, in particular dyspepsia. Dyspepsia is strictly related to younger age, no smoking, and absence of anemia.

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“…A possible source of error in permeability studies of the stomach is delayed gastric emptying. Although being a controversial issue, this has been shown to occur in patients with chronic and atrophic gastritis [22,23,24]. Another possible source of error in atrophic gastritis could be the reduced volume of gastric fluid secretion [25].…”

Section: Discussionmentioning

confidence: 99%

Atrophic Gastritis Is Associated with Increased Sucrose Permeability Related to Chronic Inflammation

et al. 2005

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Background: Different theories have been presented to explain how atrophic gastritis may lead to gastric cancer development. One contributing factor could be impaired function of the gastric mucosal barrier. The aim of this study was to investigate if there are changes in gastric mucosal permeability to sucrose in atrophic gastritis.Methods: The study comprised 22 patients with atrophic gastritis and 21 normal controls. Gastritis was classified according to the Sydney system from endoscopic biopsies of the gastric corpus and antrum. All subjects were exposed to oral sucrose load (100 g), and the fraction of sucrose excreted in urine was measured by gas chromatography-mass spectrometry. Results: The fraction of sucrose excreted in urine after oral load was significantly increased in atrophic gastritis compared with controls (median 0.08 vs. 0.04%; p = 0.003). Sucrose excretion was positively related to the degree of chronic inflammation (median fraction excreted: mild inflammation 0.06%, moderate inflammation 0.08%, severe inflammation 0.18%; p = 0.04) rather than to the degree of atrophy in the gastric mucosa. Occurrence of intestinal metaplasia was also associated with significantly higher sucrose excretion. However, in multivariate analysis, including intestinal metaplasia, only the degree of inflammation was positively related to sucrose excretion. Conclusion: Atrophic gastritis is associated with increased sucrose permeability, suggesting paracellular leakage of the gastric mucosa. This leakage seems to be related to the degree of inflammation rather than the degree of atrophy. The findings may have implications for the diseases and complications associated with atrophic gastritis.

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Cited by 29 publications

References 22 publications

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Upper gastrointestinal symptoms in autoimmune gastritis

Atrophic Gastritis Is Associated with Increased Sucrose Permeability Related to Chronic Inflammation

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