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Ngo, Tung H.; Barnard, R. James; Tymchuk, Christopher N.; Cohen, Pinchas; Aronson, William J.

doi:10.1023/a:1021911517010

Cited by 103 publications

(51 citation statements)

References 36 publications

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“…The inhibition of prostate [27,28,29,30,31,32,33,34], mammary [35], and hepatocellular [36] cancer cell proliferation from serum taken following a chronic diet and exercise intervention was significant when compared to cells treated with serum taken from sedentary controls or pre-intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Exercise affects the levels of circulating hormones, growth factors, and cytokines, and in recent years contracting/exercising skeletal muscle has been recognized as an important tissue producing and releasing into the bloodstream myokines and other substances that affect the functionality of other tissues, resulting in health benefits [37]. The effect of exercise on serum factors and their subsequent contribution to exercises’ anti-cancer effects has been assessed in prostate [28,29,30,31,32] and breast [35] cancer cell lines. Individuals participating in regular exercise training had lower serum testosterone, estradiol, and insulin levels compared to sedentary controls, and when these hormones were added to the serum of men in the intervention/exercise group to match the higher levels in the serum from the sedentary group, the reduction in prostate cancer cell growth originally seen in the exercise group was attenuated [29].…”

Section: Discussionmentioning

confidence: 99%

“…We measured serum insulin and found no significant differences between the pre- and post-exercise levels, indicating that the observed effects are not due to insulin. Evidence indicates that regular chronic exercise resulted in decreased insulin-like growth factor-1 (IGF-1) and increased insulin-like growth factor binding protein-1 (IGFBP-1) serum levels [24,28,30,31,32,35]. When IGF-1 was added to post-intervention serum to match the IGF-1 levels in the pre-intervention serum, the inhibition in prostate cancer cell growth was attenuated [32].…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2

Kurgan

Tsakiridis

Kouvelioti

et al. 2017

Cancers

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Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases, and for the most cancer-related deaths. The survival pathway of Akt, its downstream effectors, the mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase (p70 S6K), and the Ras-extracellular signal-regulated kinase (Erk1/2) pathways are activated in cancer leading to cell survival and growth. Thus, approaches that inhibit these signaling molecules may prove useful in the fight against lung cancer. Exercise is associated with health benefits and a limited number of studies indicate that serum from physically active individuals inhibit mammary and prostate cancer cell growth. In this study, we examined the effects of post exercise serum on proliferation, survival, and signaling cascades of human NSCLC cells. Blood was collected from male subjects prior to, 5 min, 1 h, and 24 h after a single bout of high intensity interval exercise on a cycle ergometer. Exposure of NSCLC cells to post exercise serum resulted in the inhibition of cell proliferation and survival, as well as significant reduction of phosphorylated/activated Akt, mTOR, p70 S6K, and Erk1/2 levels compared to cells treated with serum taken pre-exercise. Our data suggest that post exercise serum has anti-cancer properties in lung cancer and deserves further systematic investigation in animal models.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2

Kurgan

Tsakiridis

Kouvelioti

et al. 2017

Cancers

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“…[34][35][36][37] Beneficial changes in IGF-axis proteins have been observed in vivo with a low-fat diet; routine exercise in older men at risk for prostate cancer has been shown to reduce cancer cell growth in vitro. 30,38,39 To assess whether men undergoing ADT for prostate cancer would experience similar changes in the IGF-axis proteins, Bourke and colleagues 18 randomized 50 patients to 3 months of mixed-modality exercise and dietary advice or usual care. At the end of the intervention, they found no difference between intervention participants and controls in any of the biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Exercise effects on adipokines and the IGF axis in men with prostate cancer treated with androgen deprivation: A randomized study

Mina

Connor²,

Alibhai³

et al. 2013

CUAJ

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Background: Androgen deprivation therapy (ADT) has significant deleterious effects on body composition that may be accompanied by unfavourable changes in adipokine levels. While exercise has been shown to improve a number of side effects associated with ADT for prostate cancer, no studies have assessed the effect of exercise on adiponectin and leptin levels, which have been shown to alter the mitogenic environment. Methods: Twenty-six men with prostate cancer treated with ADT were randomized to home-based aerobic exercise training or resistance exercise training for 24 weeks. Adiponectin, leptin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) were analyzed by ELISA (enzyme-linked immunosorbent assay), in addition to physical activity volume, peak aerobic capacity, and anthropometric measurements, at baseline, 3 months and 6 months. Results: Resistance exercise significantly reduced IGF-1 after 3 months (p = 0.019); however, this change was not maintained at 6 months. At 6 months, IGFBP-3 was significantly increased compared to baseline for the resistance training group (p = 0.044).In an exploratory analysis of all exercisers, favourable changes in body composition and aerobic fitness were correlated with favourable levels of leptin, and favourable leptin:adiponectin and IGF-1:IGFBP-3 ratios at 3 and 6 months. Conclusions: Home-based exercise is correlated with positive changes in adipokine levels and the IGF-axis that may be related to healthy changes in physical fitness and body composition. While the improvements of adipokine markers appear to be more apparent with resistance training compared to aerobic exercise, these findings must be considered cautiously and require replication from larger randomized controlled trials to clarify the role of exercise on adipokines and IGF-axis proteins for men with prostate cancer.

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“…Physical activity may reduce circulating levels of insulin and insulin-like growth factors [26][27][28] which have been associated with an increased risk of prostate cancer [29][30][31][32]. Possible limitations of the present study need to be considered.…”

Section: Discussionmentioning

confidence: 92%

Lifetime total physical activity and prostate cancer risk: a population-based case–control study in Sweden

et al. 2008

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The etiologic role of physical activity in prostate cancer development is unclear. We assessed the association between lifetime total physical activity and prostate cancer risk in a Swedish population-based case-control study comprising 1,449 incident prostate cancer cases and 1,118 unaffected population controls. Information regarding physical activity was obtained via a self-administered questionnaire assessing occupational, household, and recreational activity separately at various ages throughout an individual's lifetime. Clinical data (TNM-classification, Gleason sum and PSA) was obtained from linkage to the National Prostate Cancer Registry. Overall, we observed no association between lifetime total physical activity and prostate cancer risk (odds ratio [OR] = 1.04, 95% confidence interval [CI] = 0.77-1.41 for > or =49.7 vs. <41.9 metabolic equivalent-hours per day). There was a significantly increased risk of prostate cancer in the most active men compared with the least active men in household (OR = 1.44, 95% CI = 1.08-1.92) and recreational physical activity (OR = 1.56, 95% CI = 1.16-2.10). Comparing the most active with the least active men, total physical activity was not associated with either localized disease (OR = 0.95, 95% CI = 0.67-1.34) or advanced disease (OR = 1.19, 95% CI = 0.83-1.71). These findings do not support the hypothesis that physical activity uniformly protects against prostate cancer development.

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Abstract: A low-fat diet and exercise intervention induces in-vivo changes in the circulating IGF axis and is associated with reduced growth and enhanced apoptosis/necrosis of LNCaP tumor cells in vitro.

Cited by 103 publications

References 36 publications

Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2

Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2

Exercise effects on adipokines and the IGF axis in men with prostate cancer treated with androgen deprivation: A randomized study

Lifetime total physical activity and prostate cancer risk: a population-based case–control study in Sweden

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