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Zhang, S. M.; Cui, Fuzhai; Liao, Susan; Zhu, Ya; Han, Lin-Hai

doi:10.1023/a:1024083309982

Cited by 118 publications

(23 citation statements)

References 15 publications

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“…The diffraction results of the CSH/nHAC composite prepared in this experiment were same as previously described [37]. CSD appeared owing to the hydration of CSH [24].…”

Section: Resultssupporting

confidence: 61%

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

Liu¹,

Mao²,

Liu³

et al. 2013

PLoS ONE

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A novel biomimetic bone scaffold was successfully prepared in this study, which was composed of calcium sulfate hemihydrate (CSH), collagen and nano-hydroxyapatite (nHAC). CSH/nHAC was prepared and observed with scanning electron microscope and rhBMP-2 was introduced into CSH/nHAC. The released protein content from the scaffold was detected using high performance liquid chromatography at predetermined time interval. In vivo bone formation capacity was investigated by means of implanting the scaffolds with rhBMP-2 or without rhBMP-2 respectively into a critical size defect model in the femoral condyle of rabbit. The releasing character of rhBMP-2 was that an initial burst release (37.5%) was observed in the first day, followed by a sustained release and reached 100% at the end of day 20. The CSH/nHAC showed a gradual decrease in degradation with the content of nHAC increase. The results of X-rays, Micro CT and histological observation indicated that more new bone was formed in rhBMP-2 group. The results implied that this new injectable bone scaffold should be very promising for bone repair and has a great potential in bone tissue engineering.

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“…The diffraction results of the CSH/nHAC composite prepared in this experiment were same as previously described [37]. CSD appeared owing to the hydration of CSH [24].…”

Section: Resultssupporting

confidence: 61%

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

Liu¹,

Mao²,

Liu³

et al. 2013

PLoS ONE

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“…11 Furthermore, it is often used in composite bone graft materials 43–45 because of its excellent biocompatibility and low immunogenicity. 46 Coating scaffolds with SIM-containing alginate resulted in a progressive and sustained release of SIM, as demonstrated for concentrations of 2.4 and 0.6 mM SIM.…”

Section: Discussionmentioning

confidence: 99%

Enhanced in vitro osteoblast differentiation on TiO₂ scaffold coated with alginate hydrogel containing simvastatin

et al. 2013

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The aim of this study was to develop a three-dimensional porous bone graft material as vehicle for simvastatin delivery and to investigate its effect on primary human osteoblasts from three donors. Highly porous titanium dioxide (TiO2) scaffolds were submerged into simvastatin containing alginate solution. Microstructure of scaffolds, visualized by scanning electron microscopy and micro-computed tomography, revealed an evenly distributed alginate layer covering the surface of TiO2 scaffold struts. Progressive and sustained simvastatin release was observed for up to 19 days. No cytotoxic effects on osteoblasts were observed by scaffolds with simvastatin when compared to scaffolds without simvastatin. Expression of osteoblast markers (collagen type I alpha 1, alkaline phosphatase, bone morphogenetic protein 2, osteoprotegerin, vascular endothelial growth factor A and osteocalcin) was quantified using real-time reverse transcriptase–polymerase chain reaction. Secretion of osteoprotegerin, vascular endothelial growth factor A and osteocalcin was analysed by multiplex immunoassay (Luminex). The relative expression and secretion of osteocalcin was significantly increased by cells cultured on scaffolds with 10 µM simvastatin when compared to scaffolds without simvastatin after 21 days. In addition, secretion of vascular endothelial growth factor A was significantly enhanced from cells cultured on scaffolds with both 10 nM and 10 µM simvastatin when compared to scaffolds without simvastatin at day 21. In conclusion, the results indicate that simvastatin-coated TiO2 scaffolds can support a sustained release of simvastatin and induce osteoblast differentiation. The combination of the physical properties of TiO2 scaffolds with the osteogenic effect of simvastatin may represent a new strategy for bone regeneration in defects where immediate load is wanted or unavailable.

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“…Moreover, CNTs or CNFs embedded in a biodegradable polymer exhibit biocompatibility even after release into blood vessels. The work carried out by Sitharaman et al showed that the in vivo biocompatibility of ultra-short SWCNT/PPF nanocomposites is similar to that of PPF alone, and the tissue response they elicit is similar to that of other polymers and nanocomposites used for tissue engineering [52, 103–106]. Hence, it is anticipated that CNTs or CNFs embedded in biodegradable polymers do not pose a threat to biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Tangible nanocomposites with diverse properties for heart valve application

Vellayappan

Balaji

Subramanian

et al. 2015

Science and Technology of Advanced Materials

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Cardiovascular disease claims millions of lives every year throughout the world. Biomaterials are used widely for the treatment of this fatal disease. With the advent of nanotechnology, the use of nanocomposites has become almost inevitable in the field of biomaterials. The versatile properties of nanocomposites, such as improved durability and biocompatibility, make them an ideal choice for various biomedical applications. Among the various nanocomposites, polyhedral oligomeric silsesquioxane-poly(carbonate-urea)urethane, bacterial cellulose with polyvinyl alcohol, carbon nanotubes, graphene oxide and nano-hydroxyapatite nanocomposites have gained popularity as putative choices for biomaterials in cardiovascular applications owing to their superior properties. In this review, various studies performed utilizing these nanocomposites for improving the mechanical strength, anti-calcification potential and hemocompatibility of heart valves are reviewed and summarized. The primary motive of this work is to shed light on the emerging nanocomposites for heart valve applications. Furthermore, we aim to promote the prospects of these nanocomposites in the campaign against cardiovascular diseases.

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Untitled

Cited by 118 publications

References 15 publications

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

Enhanced in vitro osteoblast differentiation on TiO₂ scaffold coated with alginate hydrogel containing simvastatin

Tangible nanocomposites with diverse properties for heart valve application

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Untitled

Cited by 118 publications

References 15 publications

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

Enhanced in vitro osteoblast differentiation on TiO2 scaffold coated with alginate hydrogel containing simvastatin

Tangible nanocomposites with diverse properties for heart valve application

Contact Info

Product

Resources

About

Enhanced in vitro osteoblast differentiation on TiO₂ scaffold coated with alginate hydrogel containing simvastatin