Pp30 Peptic or Allergic Eosinophilic Esophagitis?

Efficacy of Proton Pump Inhibitor Drugs for Inducing Clinical and Histologic Remission in Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review and Meta-Analysis

“…Among the remaining 47 documents retrieved for complete evaluation, 14 were excluded because of a lack of data for calculations (11 documents) or either repeated or duplicated information (3 documents). Finally, 33 studies (comprising 28 full reports [11][12][13][14] and 5 abstracts [47][48][49][50][51][52] ) were included in the quantitative summaries of our systematic review ( Figure 1). Most of the research retrieved consisted of observational studies and case reports or series, with only 2 randomized controlled trials developed on this topic.…”

“…Regarding the main outcomes in this meta-analysis depending on the type of PPI used, data were mixed, with lansoprazole and rabeprazole showing a nonsignificantly higher histologic remission rate (70%), accompanied by an identical symptom remission rate in the case of rabeprazole. These data, however, should be viewed with caution because they come from only 6 studies comprising 46 patients, 14,25,32,43,48 and most of them were case reports or retrospective studies. Among these studies, a prospective study published in 2011 (using rabeprazole 20 mg twice daily for 8 weeks) also was included, which reported a 75% histologic remission rate.…”