PP2A-B56 regulates Mid1 protein levels for proper cytokinesis in fission yeast
Madeline L. Chrupcala,
James B. Moseley
Abstract:Protein phosphorylation regulates many steps in the cell division process including cytokinesis. In the fission yeastS. pombe, the anillin-like protein Mid1 sets the cell division plane and is regulated by phosphorylation. Multiple protein kinases act on Mid1, but no protein phosphatases have been shown to regulate Mid1. Here, we discovered that the conserved protein phosphatase PP2A-B56 is required for proper cytokinesis by promoting Mid1 protein levels. We find thatpar1Δ cells lacking the primary B56 subunit… Show more
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