PP121. Expression of PlGF, sFlt, MTF-1, HO-1 and HIF-1 alpha mRNAs in preeclampsia placenta and effect of preeclampsia sera on their expression of choriocarcinoma cells

Maebayashi, Aki; Yamamoto, Tatsuo; Azuma, Hiromitsu; Kato, Eisuke; Kuno, S; Murase, Takayuki; Chishima, Fumihisa

doi:10.1016/j.preghy.2012.04.232

Cited by 1 publication

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“…Our findings disagree with some studies reporting decreased expression of PlGF mRNA in PE patients ( 12 , 29 , 32 ). Andraweera and coworkers; reported reduced expression of PlGF mRNA in placental of PE patients ( 12 ).…”

Section: Discussioncontrasting

confidence: 99%

“…Meanwhile most studies related to sFlt-1 level in pregnancy shows elevated levels in peripheral blood of women with PE (18, 29). Decreased circulating PlGF level which is observed in PE patients could be explained by antagonising by sFlt-1 as a potent anti-angiogenic factor.…”

Section: Discussionmentioning

confidence: 99%

“…Shibata and coworkers reported lower levels of PlGF in serum samples of women affected to PE compared with normal controls ( 28 ). Meanwhile most studies related to sFlt-1 level in pregnancy shows elevated levels in peripheral blood of women with PE ( 18 , 29 ). Decreased circulating PlGF level which is observed in PE patients could be explained by antagonising by sFlt-1 as a potent anti-angiogenic factor.…”

Section: Discussionmentioning

confidence: 99%

“…Our results showed no significant difference in mRNA expression in PE patients compared with normal controls. Only a few studies reported mRNA alterations in patients affected to PE ( 12 , 29 , 32 ). Our results are in accordance with the findings of previous studies which reported no significant difference between the level of PlGF mRNA expression in PE women compared to normal controls ( 8 , 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…Andraweera and coworkers; reported reduced expression of PlGF mRNA in placental of PE patients ( 12 ). Maebayashi and colleagues reported a significant decrease in PlGF mRNA in placenta of PE patients compared to the controls ( 29 ). Purwosunu and coworkers studied about the expression of genes related to angiogenesis in blood of preeclamptic women and the results of their study showed reduced expression of PlGF mRNA ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

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Expression of placental growth factor mRNA in preeclampsia

Nikuei

Rajaei

Malekzadeh

et al. 2017

IJRM

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Background:Preeclampsia (PE) is a serious complication of pregnancy with hallmarks of incomplete placentation, placental ischemia and endothelial dysfunction. Imbalance between vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors play important role in pathophysiology of PE. Objective:This study was aimed to asses PlGF mRNA expression in placenta of women affected with PE.Material and Methods:In this cross-sectional study, expression of PlGF mRNA was evaluated in 26 mild PE cases, 15 severe preeclamptic women and 20 normotensive controls. Patients were sub-classified as early onset PE (9) and late onset (32). After RNA extraction, PlGF expression was quantified with qRT-PCR. Results:The results of PlGF mRNA expression between mild-severe, and early-late onset PE patients showed no statistically significant difference compared with the control group (p=0.661, p=0.205 respectively).Conclusion:Despite we found no distinct differential expression of PlGF mRNA in placental tissue of PE patients compared with control women, but according to decreased level of this angiogenic factor in PE even before clinical onset of the disease, determining molecular mechanisms related to reduced secretion of PlGF into the maternal circulation may be useful for future therapeutics.

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