PP113. NT-Pro-BNP: A predictor of adverse maternal outcomes in hypertensive gestational syndromes?

Fustaret, Marcela C. Cabo; Escobar, Ana Maria de Ulhôa; Illia, Ricardo; Uranga, M.; Rivas, Carlos; Lobenstein, Guillermo; Olejnik, Patricia; Mayer, H.; Ramilo, T.P.

doi:10.1016/j.preghy.2012.04.224

Cited by 5 publications

(5 citation statements)

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“…17 By the results in the present study, a reduction in LVEF was seen between women with pre-eclampsia and normotensive women, and these changes coincided with an increase in levels of BNP. 18 A study by Sheikh et al 19 concluded that NT-proBNP levels are useful as a diagnostic tool among pregnant and newly delivered women to diagnose cardiac complications, including heart failure and pre-eclampsia, which supports the conclusion of the present study.This was a prospective case-control study and could evaluate multiple variables. The effects of HDP were studied on all the affected organ systems.…”

Section: Discussionsupporting

confidence: 86%

Left ventricular function and N‐terminal pro b‐type natriuretic peptide levels in women with hypertensive disorders of pregnancy: A prospective observational study

Verma

Malik

2022

Intl J Gynecology & Obste

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Pre-eclampsia is a syndrome occurring in pregnancy that involves virtually every organ system. A systematic review by WHO determined that in developed countries, 16% of maternal deaths were attributed to hypertensive disorders. 1 Almost one in four mothers with pre-eclampsia/eclampsia is at risk of persistent hypertension after the puerperium. 2 Pre-eclampsia is seen to recur in pregnancies at a rate of 20%-25%. 3 In India, the incidence of pre-eclampsia is reported to be 8%-10% among pregnant women. 4 In a study by Manjusha Sajith in Pune including 1330 women visiting the antenatal clinic, the prevalence of hypertensive disorders of pregnancy (HDP) was 7.8% (104 women) with pre-eclampsia in 5.6% (75 women) of the study population. 5 The maternal outcomes are more likely to be adverse if preeclampsia occurs before 32 weeks of pregnancy or in association with pre-existing comorbidities such as renal disease/ pregestational type 1 or type 2 diabetes mellitus. 6

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Section: Discussionsupporting

confidence: 86%

Left ventricular function and N‐terminal pro b‐type natriuretic peptide levels in women with hypertensive disorders of pregnancy: A prospective observational study

Verma

Malik

2022

Intl J Gynecology & Obste

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“…94–99 Most studies have shown that brain natriuretic peptide (BNP) levels remain unchanged compared with preconception levels in normotensive women throughout pregnancy. 100–103 One longitudinal study of 29 healthy pregnant women showed no significant differences between BNP levels throughout trimesters and in the postpartum period, though pregnant BNP levels were approximately twice as high as in non-pregnant controls. 100 In healthy women BNP levels rose approximately 2–3-fold in the first 48 h postpartum returning to baseline 6–12 weeks’ postpartum.…”

Section: Cardiac Markersmentioning

confidence: 99%

“…Chronic hypertension, gestational hypertension and PET are all associated with elevated BNP. [102][103][104] In individuals with PET, elevation of BNP may persist for 3-6 months' postpartum. 105 Studies as to whether PET is associated with a rise in cTnI have revealed inconsistent results.…”

Section: Cardiac Markersmentioning

confidence: 99%

Changes in biochemical tests in pregnancy and their clinical significance

Teasdale

Morton

2018

Obstet Med

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Interpretation of laboratory investigations relies on reference intervals. Physiological changes in pregnancy may result in significant changes in normal values for many biochemical assays, and as such results may be misinterpreted as abnormal or mask a pathological state. The aims of this review are as follows: 1. To review the major physiological changes in biochemical tests in normal pregnancy. 2. To outline where these physiological changes are important in interpreting laboratory investigations in pregnancy. 3. To document the most common causes of abnormalities in biochemical tests in pregnancy, as well as important pregnancy-specific causes.

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“…Mild elevation of BNP postpartum may represent a physiologic change and not cardiac pathology. Chronic hypertension, gestational hypertension and pre‐eclampsia (PET) are all associated with elevated BNP . In women with PET, elevation of BNP may persist for 3–6 months postpartum …”

Section: Laboratory Investigationsmentioning

confidence: 99%

“…Levels of cardiac troponin (cTnI) are unchanged in healthy pregnancy and are unaffected by labour, anaesthesia or caesarean section . Most studies have shown that brain natriuretic peptide (BNP) levels remain unchanged in normotensive pregnancy compared with pre‐conception levels . One longitudinal study of 29 healthy pregnant women showed no significant differences between BNP levels throughout trimesters although pregnant BNP levels were approximately double those in non‐pregnant controls .…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Review article: Investigations and the pregnant woman in the emergency department – part 1: Laboratory investigations

Morton

Teasdale

2018

Emerg Medicine Australasia

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Accurate assessment of the pregnant patient in the ED depends on knowledge of physiological changes in pregnancy, and how these changes may impact on pathology tests, appearance on point‐of‐care ultrasound and electrocardiography. In addition the emergency physician needs to be cognisant of disorders that are unique to or more common in pregnancy. Part 1 of this review addresses potential deviations in laboratory investigation reference intervals resulting from physiological alterations in pregnancy, and the important causes of abnormal laboratory results in pregnancy. Part 2 will address the role of point‐of‐care ultrasound in pregnancy, physiological changes that may affect interpretation of point‐of‐care ultrasound, physiological changes in electrocardiography, and the safety of radiological procedures in the pregnant patient.

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PP113. NT-Pro-BNP: A predictor of adverse maternal outcomes in hypertensive gestational syndromes?

Cited by 5 publications

References 0 publications

Left ventricular function and N‐terminal pro b‐type natriuretic peptide levels in women with hypertensive disorders of pregnancy: A prospective observational study

Left ventricular function and N‐terminal pro b‐type natriuretic peptide levels in women with hypertensive disorders of pregnancy: A prospective observational study

Changes in biochemical tests in pregnancy and their clinical significance

Review article: Investigations and the pregnant woman in the emergency department – part 1: Laboratory investigations

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