PP1.0 – 1848 The reparative effects of neural stem cells in neonatal hypoxic ischemic injury are not influenced by host gender

Ashwal, S; Ghosh, Nirmalya; Turenius, Christine I.; Dulcich, Melissa S.; Denham, C A; Tone, Beatriz; Hartman, Richard E.; Snyder, EY; Obenaus, André

doi:10.1016/s1090-3798(13)70101-6

Cited by 2 publications

(6 citation statements)

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“…1). These results are similar to the ones reported in animals submitted to HI at PND 7 [31,45]. Huang and co-workers observed delayed righting reflex 72 h in HI animals exposed to 150 min of hypoxia when compared to control group.…”

Section: Discussionsupporting

confidence: 89%

Tissue Injury and Astrocytic Reaction, But Not Cognitive Deficits, Are Dependent on Hypoxia Duration in Very Immature Rats Undergoing Neonatal Hypoxia–Ischemia

et al. 2019

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Preterm birth and hypoxia-ischemia (HI) are major causes of neonatal death and neurological disabilities in newborns. The widely used preclinical HI model combines carotid occlusion with hypoxia exposure; however, the relationship between different hypoxia exposure periods with brain tissue loss, astrocyte reactivity and behavioral impairments following HI is lacking. Present study evaluated HI-induced behavioral and morphological consequences in rats exposed to different periods of hypoxia at postnatal day 3. Wistar rats of both sexes were assigned into four groups: control group, HI-120 min, HI-180 min and HI-210 min. Neurodevelopmental reflexes, exploratory abilities and cognitive function were assessed. At adulthood, tissue damage and reactive astrogliosis were measured. Animals exposed to HI-180 and HI-210 min had delayed neurodevelopmental reflexes compared to control group. Histological assessment showed tissue loss that was restricted to the ipsilateral hemisphere in lower periods of hypoxia exposure (120 and 180 min) but affected both hemispheres when 210 min was used. Reactive astrogliosis was increased only after 210 min of hypoxia. Interestingly, cognitive deficits were induced regardless the duration of hypoxia and there were correlations between behavioral parameters and cortex, hippocampus and corpus callosum volumes. These results show the duration of hypoxia has a close relationship with astrocytic response and tissue damage progression. Furthermore, the long-lasting cognitive memory deficit and its association with brain structures beyond the hippocampus suggests that complex anatomical changes should be involved in functional alterations taking place as hypoxia duration is increased, even when the cognitive impairment limit is achieved.

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Section: Discussionsupporting

confidence: 89%

Tissue Injury and Astrocytic Reaction, But Not Cognitive Deficits, Are Dependent on Hypoxia Duration in Very Immature Rats Undergoing Neonatal Hypoxia–Ischemia

et al. 2019

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“…HI females perform worse than males during the training period for spatial tasks, having higher latency to find the platform and greater swimming path lengths in the Morris water maze (Arteni et al, ; Tsuji et al, ; Hill et al, ; Sanches et al, , Smith et al, ; Peterson et al, ). However, other authors did not find sex differences (Pereira et al, ; Pimentel‐Coelho et al, ; Uluc et al, ; Ashwal et al, ; Waddell et al, ) or else report poor performance in HI males in the water maze (Huang et al, ).Conflicting results might arise from differences in experimental protocols and rodent strains; however, no clear explanation is available.…”

Section: Sex Differences In Behavioral Outcome and Severity Of Brain mentioning

confidence: 96%

“…The developmental delay of physical characteristics, i.e., eye opening, ear unfolding, and incisor eruption, along with neurological reflexes, such as cliff aversion, gait, grasp, and limb placing, seem to be dependent on the severity of the injury and independent of sex (Ashwal et al, ; Huang et al, ; Nie et al, ). Motor skills in males appear to be more vulnerable to HI in the negative geotaxis test (Huang et al, ; Waddell et al, ).…”

Section: Sex Differences In Behavioral Outcome and Severity Of Brain mentioning

confidence: 99%

“…Open‐field studies of HI rats show conflicting results, with reports of increased locomotion in males (Arteni et al, ) and in females (Sanches et al, ). Some indicators of anxiety such as the increase in time spent in the enclosed arms during the plus maze test are observed mainly in HI females (Arteni et al, ; Ashwal et al, ; Sanches et al, ); however, the reduction of time spent in the central area of the open field is shown by HI males (Waddell et al, ). The lack of clear evidence of sex‐specific exploratory and anxious behavior could be related to the small number of studies comparing both sexes and controlling animal age, HI protocols, and severity of brain damage.…”

Section: Sex Differences In Behavioral Outcome and Severity Of Brain mentioning

confidence: 99%

“…The morphological impact after HI has been correlated with cognitive and motor deficits (Bona et al, ) and associated with brain lateralization, age, and sex (Arteni et al, ; Sanches et al, ). Although some authors have reported no significant differences between males and females (Hilton et al, ; Hagberg et al, ; Pereira et al, ; Mayoral et al, ; Tsuji et al, ; Smith et al, ; Ashwal et al, ), HI males seem to be more susceptible to tissue loss in structures such as the cerebral cortex and hippocampus, accompanied by ventriculomegaly (Zhu et al, ; Mayoral et al, , Hill et al, ), and females appear to have a greater reduction of hemispheric volume (Sanches et al, ). Additionally, some studies suggest that HI females are more severely affected in striatum and white matter (Arteni et al, ; Sanches et al, ; Uluc et al, ), whereas others indicate that males are more severely affected (Zhu et al, ; Mayoral et al, ).…”

Section: Sex Differences In Behavioral Outcome and Severity Of Brain mentioning

confidence: 99%

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Sex‐dependent consequences of neonatal brain hypoxia‐ischemia in the rat

Netto

Sanches

Odorcyk

et al. 2016

J of Neuroscience Research

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Neonatal hypoxia-ischemia (HI) is an important cause of neurological deficits in humans, and the Levine-Rice model of experimental HI in the rat mimics the human brain lesion and the following sensory motor deficits and cognitive disabilities. With the growing evidence that sex influences all levels of brain functions, this Mini-Review highlights studies in which sex was a controlled variable and that provided evidence of sexual dimorphism in behavioral outcome, extension of brain damage, mechanisms of lesion, and treatment efficacy in the rat neonatal HI model. It was shown that 1) females have greater memory deficits; 2) cell death is dependent mainly on caspase activation in females; 3) males are more susceptible to oxidative stress; and 4) treatments acting on distinct cell death pathways afford sex-dependent neuroprotection. These tentative conclusions, along with growing evidence from other fields of neurobiology, support the need for scientists to design their experiments considering sex as an important variable; otherwise, important knowledge will continue to be missed. It is conceivable that sex can influence the development of efficacious therapeutic tools to treat neonates suffering from brain HI. V C 2016 Wiley Periodicals, Inc.

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PP1.0 – 1848 The reparative effects of neural stem cells in neonatal hypoxic ischemic injury are not influenced by host gender

Cited by 2 publications

References 0 publications

Tissue Injury and Astrocytic Reaction, But Not Cognitive Deficits, Are Dependent on Hypoxia Duration in Very Immature Rats Undergoing Neonatal Hypoxia–Ischemia

Tissue Injury and Astrocytic Reaction, But Not Cognitive Deficits, Are Dependent on Hypoxia Duration in Very Immature Rats Undergoing Neonatal Hypoxia–Ischemia

Sex‐dependent consequences of neonatal brain hypoxia‐ischemia in the rat

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