PP019 The role of renal markers in women with and without preeclampsia: Evaluation of urinary excretion of podocytes and proteins

Sass, Nelson; Facca, Thais Alquezar; Pereira, Amelia Rodrigues; Famá, Eduardo Augusto Brosco; Nishida, Sônia K.; Moreira, Silvia Regina; Teixeira, Vicente P.C.; Kirsztajn, Gianna Mastroianni

doi:10.1016/j.preghy.2012.04.130

Cited by 1 publication

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“…Importantly, the underlying maternal condition could also be at stake: a chronic vascular disease preceding the pregnancy, such as diabetes or hypertension, would be an additional facilitating factor for tubular injury (in so called maternal, as opposed to placental, preeclampsia) [32]. The measure of low-molecular weight proteins in urine is non-invasive and may be informative with regard to tubular damage: retinol-binding protein (RBP), a small protein produced by the liver, is normally reabsorbed by the proximal tubule [33,34]. Urinary RBP will increase if an ischemic injury has led to ATN and can be similarly expressed as a ratio, over urinary creatinine, in a spot sample.…”

Section: Preeclamptic Syndromesmentioning

confidence: 99%

Why kidneys fail post-partum: a tubulocentric viewpoint

et al. 2018

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Kidneys may fail post-partum in a number of circumstances due, for example, to post-partum haemorrhage, preeclampsia, amniotic fluid embolism or septic abortion. All these conditions in pregnancy and post partum represent a threat not only to the endothelium but also to the renal tubular epithelium, and as such may lead to rapid and also irreversible impairment of the renal function. This paper is a non-systematic review of the literature and of our experience, in which we discuss the main open issues on kidney disease in pregnancy and following delivery, in particular as regards tubular damage, with the aim to help reasoning on acute kidney injury (AKI) following delivery. The review will emphasize the often under-estimated importance of the tubular epithelium in the peri-partum period and will: (1) describe the main characteristics of the renal tissues around delivery; (2) define pregnancy-related AKI according to recent Kidney Disease/Improving Global Outcome (KDIGO) guidelines; (3) discuss the most common circumstances of post-partum AKI; and (4) describe the input expected from urinalysis, renal imaging and kidney biopsy.

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Section: Preeclamptic Syndromesmentioning

confidence: 99%