PP.LB01.19

Pereira, Valter Luis; Santos, Sandra Gomes dos; Fuzatti, J.S.; Campos, Luciana Aparecida; Baltatu, Ovidiu Constantin

doi:10.1097/01.hjh.0000468141.83380.a7

Cited by 3 publications

(1 citation statement)

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“…We previously investigated the relationship between carotid IMT and cardiovagal dysfunction assessed through frequency (Pereira et al, 2013) and time-domain (Pereira et al, 2015) HRV measures of 20-min office ECG measurement in patients with subclinical carotid atherosclerosis. Time-domain indices of HRV had the strongest inverse correlation with carotid IMT.…”

Section: Discussionmentioning

confidence: 99%

Association between Carotid Intima Media Thickness and Heart Rate Variability in Adults at Increased Cardiovascular Risk

et al. 2017

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Background: Atherosclerotic carotid intima-media thickness (IMT) may be associated with alterations in the sensitivity of carotid baroreceptors. The aim of this study was to investigate the association between carotid IMT and the autonomic modulation of heart rate variability (HRV).Methods: A total of 101 subjects were enrolled in this prospective observational study. The carotid IMT was determined by duplex ultrasonography. The cardiac autonomic function was determined through HRV measures during the Deep Breathing Test. Linear regression models, adjusted for demographics, comorbidities, body mass index, waist-hip-ratio, and left ventricular ejection fraction were used to evaluate the association between HRV parameters and carotid IMT.Results: Participants had a mean age of 60.4 ± 13.4 years and an estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk score (using the Pooled Cohort Equations) of 16.4 ± 17. The mean carotid media thickness was highest (0.90 ± 0.19 mm) in the first quartile of the standard deviation of all RR intervals (SDNN) (19.7 ± 5.1 ms) and progressively declined in each subsequent quartile to 0.82 ± 0.21 mm, 0.81 ± 0.16 mm, and 0.68 ± 0.19 in quartiles 2 (36.5 ± 5.9 ms), 3 (57.7 ± 6.2 ms) and 4 (100.9 ± 22.2 ms), respectively. In multivariable adjusted models, there was a statistical significant association between SDNN and carotid IMT (OR −0.002; 95%CI −0.003 to −0.001, p = 0.005). The same significant association was found between carotid IMT and other measures of HRV, including coefficient of variation of RR intervals (CV) and dispersion of points along the line of identity (SD2).Conclusions: In a cohort of individuals at increased cardiovascular risk, carotid IMT as a marker of subclinical atherosclerosis was associated with alterations of HRV indicating an impaired cardiac autonomic control, independently of other cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 99%

Association between Carotid Intima Media Thickness and Heart Rate Variability in Adults at Increased Cardiovascular Risk

et al. 2017

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Association between resting heart rate, VO2max and carotid intima-media thickness in middle-aged men

Kang

Ko²

2019

IJC Heart & Vasculature

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Introduction Low resting heart rate (RHR) and high cardiorespiratory fitness (VO 2 max) are associated with a reduction in cardiovascular events (CV). Carotid intima-media thickness (CIMT) has been suggested as a predictor of CV. The purpose of this study was to investigate the association between RHR, VO 2 max and CIMT. Methods The subjects of this study were 707 males aged 40–50 who visited the National Health Center of South Korea, a health examination institution, from 2010 to 2016. RHR was measured using electrocardiogram. RHR was divided into 4 levels (<60 beats per minute; bpm, 60–69 bpm, 70–79 bpm, ≥80 bpm). VO 2 max was measured by grade exercise test. Subject's VO 2 max was divided into 3 levels (first, second and third tertiles). CIMT was measured by B-mode ultrasound. Carotid atherosclerosis was defined as CIMT >1 mm. Results There was no significant difference in CIMT according to RHR level and there was no correlation between RHR and CIMT. High and middle VO 2 max group had significant lower CIMT than low VO 2 max group ( P < 0.001). There was also a correlation between VO 2 max and CIMT (R = −0.129, P < 0.001). The low VO 2 max group showed 3.56-fold (95% CI, 1.77–7.16) higher relative risk of carotid atherosclerosis than the high VO 2 max group. Conclusion These results suggest that cardiovascular fitness index VO 2 max is associated to CIMT in middle-aged men. In addition, this study shows that VO 2 max are important indicators for the prevalence of carotid atherosclerosis.

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Associations between electrocardiogram and carotid ultrasound parameters: a healthy chinese group study

Shi

Bi²,

Luo³

et al. 2022

Front. Physiol.

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Background: Electrocardiogram (ECG) and carotid ultrasound (CUS) are important tools for the diagnosis and prediction of cardiovascular disease (CVD). This study aimed to investigate the associations between ECG and CUS parameters and explore the feasibility of assessing carotid health with ECG.Methods: This cross-sectional cohort study enrolled 319 healthy Chinese subjects. Standard 12-lead ECG parameters (including the ST-segment amplitude [STA]), CUS parameters (intima-media thickness [IMT] and blood flow resistance index [RI]), and CVD risk factors (including sex, age, and systolic blood pressure [SBP]) were collected for analysis. Participants were divided into the high-level RI group (average RI ≥ 0.76, n = 171) and the normal RI group (average RI < 0.76, n = 148). Linear and stepwise multivariable regression models were performed to explore the associations between ECG and CUS parameters.Results: Statistically significant differences in sex, age, SBP, STA and other ECG parameters were observed in the normal and the high-level RI group. The STA in lead V3 yielded stronger significant correlations (r = 0.27–0.42, p < 0.001) with RI than STA in other leads, while ECG parameters yielded weak correlations with IMT (|r| ≤ 0.20, p < 0.05). STA in lead V2 or V3, sex, age, and SBP had independent contributions (p < 0.01) to predicting RI in the stepwise multivariable models, although the models for IMT had only CVD risk factors (age, body mass index, and triglyceride) as independent variables. The prediction model for RI in the left proximal common carotid artery (CCA) had higher adjusted R2 (adjusted R2 = 0.31) than the model for RI in the left middle CCA (adjusted R2 = 0.29) and the model for RI in the right proximal CCA (adjusted R2 = 0.20).Conclusion: In a cohort of healthy Chinese individuals, the STA was associated with the RI of CCA, which indicated that ECG could be utilized to assess carotid health. The utilization of ECG might contribute to a rapid screening of carotid health with convenient operations.

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PP.LB01.19

Cited by 3 publications

References 0 publications

Association between Carotid Intima Media Thickness and Heart Rate Variability in Adults at Increased Cardiovascular Risk

Association between Carotid Intima Media Thickness and Heart Rate Variability in Adults at Increased Cardiovascular Risk

Association between resting heart rate, VO2max and carotid intima-media thickness in middle-aged men

Associations between electrocardiogram and carotid ultrasound parameters: a healthy chinese group study

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