[PP.LB01.13] Ambulatory Blood Pressure Monitoring (Abpm) and Myocardium Deformation Parameters in Patients With Hypertension

Nesukay, E. G.; Polenova, N.; Titov, Ivan

doi:10.1097/01.hjh.0000491905.02911.ea

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“…(Table I) Significant target organ damage (TOD) such as left ventricular hypertrophy, stroke, changes in carotid wall thickness and atherosclerotic plaques, along with renal and ocular damage were recognized in non-dipper hypertensive patients. [7,8,21,22] Non-dipper profile is not a static marker of the cardiovascular status. Hypertension pattern identification and therapeutic interventions can improve patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical Conditions and Predictive Markers of Non-Dipper Profile in Hypertensive Patients

Ţilea

Petra

Ardeleanu

et al. 2018

Acta Medica Marisiensis

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Hypertension remains one of the primary causes of premature cardiovascular mortality representing a major independent risk factor.The importance of ambulatory blood pressure monitoring in clinical evaluation of hypertensive patients, beyond diagnosis, is the identification of circadian dipping/non-dipping profile. The non-dipper pattern in hypertensive and normotensive patients is associated with significant target organ damage and worse outcomes, as an increased cardiovascular risk condition. Non-dipping pattern has been found to be associated with specific clinical conditions. Obesity, diabetes mellitus, metabolic syndrome, obstructive sleep apnea syndrome, chronic kidney disease, autonomic and baroreflex dysfunctions, salt sensitivity, hormonal changes, gender and age were extensively studied. Research efforts are focused on recognizing and exploring predictive markers of abnormal blood pressure circadian pattern. Previous studies acknowledge that red cell distribution width, mean platelet volume, fibrinogen level, C-reactive protein, serum uric acid and gamma-glutamyltransferase, are independently significant and positive associated to non-dipping pattern. Moreover, research on new biomarkers are conducted: Chitinase 3-Like-Protein 1, atrial and B-type natriuretic peptide, brain-derived neurotrophic factor, chemerin, sphingomyelin and the G972R polymorphism of the insulin receptor substrate-1 gene. This review summarizes the current knowledge of different clinical conditions and biomarkers associated with the non-dipper profile in hypertensive patients.

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Section: Introductionmentioning

confidence: 99%