PP-340 Colchicine Intoxication Leading to Complete AV Block

Ertuğrul, İlker; Polat, Emine; Yoldaş, Tamer; Aksin, Ş.; Özgür, Selma; Örün, Utku Arman; Karademir, Sedat

doi:10.1016/j.amjcard.2014.01.370

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Es cardiotóxica, se une a los microtúbulos de la célula miocárdica y se puede encontrar taquicardia y trastornos de la conducción, también se ha reportado bloqueo aurículo-ventricular. [16][17][18] Nuestra paciente presentó inicialmente taquicardia sinusal y luego paro cardiaco coincidiendo con reportes que mencionan que las principales causas de mortalidad temprana son el compromiso cardiaco y la insuficiencia respiratoria, los pacientes que fallecen tardíamente lo hacen por pancitopenia y septicemia. 11 El cuadro clínico se presenta en tres fases, que se muestran en la tabla 2.…”

Section: Discussionunclassified

Intoxicación letal por colchicina

Valdivia-Infantas

Herrera-Miranda²,

Benites³

2022

spmi

View full text Add to dashboard Cite

show abstract

Section: Discussionunclassified

Intoxicación letal por colchicina

Valdivia-Infantas

Herrera-Miranda²,

Benites³

2022

spmi

View full text Add to dashboard Cite

show abstract

“…The other patient had a reduced ejection fraction and died because of multiorgan failure. Ertuğrul et al 16 reported a 9-year-old patient who had complete atrioventricular block after colchicine intoxication and required a pacemaker implantation.…”

Section: Discussionmentioning

confidence: 99%

Colchicine Poisoning Cases in a Pediatric Intensive Care Unit

Süzen-Orhan¹,

Gün²,

Özen³

et al. 2022

Pediatr Emer Care

View full text Add to dashboard Cite

ObjectivesColchicine intoxication is rare but potentially fatal. The toxic dose of colchicine is not well established; it has been reported that major toxicity starts after doses of 0.5 mg/kg. We aimed to evaluate the demographic, clinical aspects, treatments, and outcome of colchicine toxicity cases in the pediatric intensive care unit (PICU).MethodsWe collected the data of patients aged between 0 and 18 years, admitted to Ankara University Faculty of Medicine PICU for colchicine poisoning (n = 22), from October 1999 to January 2020, retrospectively. Data extracted from the cases included age, sex, chronic condition, time between intake of drug and admission to PICU, source of drug, amount of drug ingested, other drug intake, symptoms, clinical findings, cardiac involvement, laboratory results, time of stay in PICU, treatment, and outcome.ResultsPatients' age ranged from 7 months to 17 years. Median age was 86 months. The most common symptom at time of admission was vomiting, occurring in 13 (59%) of the patients. Two of the patients presented with change in mental status. Time between taking medication and applying to the hospital ranged from half an hour to 4 days. Medication intake of 3 of 22 patients was more than 0.5 mg/kg. One patient whose parents' best estimate of dose ingested was 0.48 mg/kg died because of the development of multiorgan failure. One patient who ingested 0.4 mg/kg of colchicine underwent plasma exchange and recovered without any complications.ConclusionsColchicine poisoning has a high risk of mortality, and death can be seen in doses less than a single acute dose of 0.5 mg/kg. These patients need close monitoring because there is always a risk of them to require aggressive support. Prognosis is poor in patients who have rapidly developing hemodynamic failure.

show abstract

PP-340 Colchicine Intoxication Leading to Complete AV Block

Cited by 2 publications

References 0 publications

Intoxicación letal por colchicina

Intoxicación letal por colchicina

Colchicine Poisoning Cases in a Pediatric Intensive Care Unit

Contact Info

Product

Resources

About