PP-019 Plasma lipids levels in patients with acute bacterial infections

Nassaji, Mohammad; Ghorbani, Raheb

doi:10.1016/s1201-9712(11)60172-0

Cited by 11 publications

(18 citation statements)

References 20 publications

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“…Some other studies described specific lipid pattern changes during acute viral and bacterial infections. [64][65][66] Because no data on lipid levels before the malaria or febrile episode were available, it was impossible to ascertain whether lipoprotein levels were low because of the malaria episode, or whether the patients were susceptible to malaria infection because of low serum lipids caused by another mechanism. In one study, decreased levels of HDL-C and TC were associated with a larger risk for nosocomial infections.…”

Section: Discussionmentioning

confidence: 99%

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Abstract. The serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol . No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 ( TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology.[

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Section: Discussionmentioning

confidence: 99%

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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“…During infection, the changes of the lipid and lipoprotein metabolism induce anti-inflammatory effects that contribute to the host defense [7]. Besides the role of lipid transport, circulating lipoproteins participate in innate immunity by binding and detoxifying lipopolysaccharide and toxins of gram-negative, and lipoteichoic acid of Gram-positive bacteria [7].…”

Section: Discussionmentioning

confidence: 99%

“…Infections also produce alterations in the composition and function of lipoproteins [78]. The existing evidences suggest that change in lipoproteins level during infection is a part of acute phase response of innate immune system [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis

Sayyahfar

Lavasani²,

Nateghian

et al. 2017

Infect Chemother

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BackgroundAcute Epstein-Barr virus (EBV) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with Infectious mononucleosis (IM). The aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery.Materials and MethodsFrom 2010 through 2012, 36 children with IM aged 1-10 years were enrolled in a prospective cross-sectional study. Fasting serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceride level were measured during acute phase of the disease and after 2 months of the recovery.ResultsFrom 36 patients enrolled, 25 (69.4%) cases were male and the mean age of the patients was 4.1 ± 2.0 years. The mean of the total cholesterol level in the acute phase and 2 months after the recovery were149.5 ± 35.3 mg/dL and 145.7±30.6, respectively (P = 0.38). However, the serum level of HDL cholesterol in patients after 2 months of recovery was significantly increased (37.9 ± 9.3 mg/dL vs. 28.5 ± 10.6 mg/dL, P <0.001). The mean value of serum LDL cholesterol was significantly reduced, two months after recovery (81.4 ± 19.5 mg/dL, vs. 92.6 ± 28.8 mg/dL, P = 0.009). Furthermore, the serum triglyceride level was significantly reduced after the recovery (108.7 ± 36.9 mg/dL) compared with the acute phase (163.8 ± 114.3 mg/dL) (P = 0.004).ConclusionEBV infection in children could change lipid profile which is partially restored 2 months after the recovery.

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“…Alvarez and Romas [35] mentioned that serum levels of high-density lipoprotein were significantly (p<0.05) decreased during sepsis. Nassaji et al [36] conducted a study among patients with acute bacterial infections and found the lower serum levels of TC and high-density lipoprotein and non-significant differences in TG and low-density lipoprotein as compared with the control. A study found that critically ill infected patients had lower TC and high-density lipoprotein when compared with non-infected patients [37].…”

Section: Discussionmentioning

confidence: 99%

“…Lipid peroxidation is one of the most important expressions of oxidative stress induced by reactive oxygen species [40]. Infections produce alterations in the composition and function of lipoproteins, including changes in sphingolipid concentrations, decreased reverse cholesterol transport, and increased oxidation of lipids [36]. Infections facilitate cytokine-induced alterations in lipid and lipoprotein metabolism leading to decreased serum levels of TC, high-density lipoprotein, and low-density lipoprotein [41].…”

Section: Discussionmentioning

confidence: 99%

Association Between Age, Body Mass Index, Waist Circumference, Lipid Profile Parameters, and Symptomatic Bacterial Urinary Tract Infection in Iraqi Adult Women

Hantoosh¹,

Al-rubai²,

Zageer³

et al. 2016

Asian J Pharm Clin Res

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Objective: This study was conducted to investigate the association between age, body mass index (BMI), waist circumference (WC), and incidence of symptomatic bacterial urinary tract infections in adult women and to study the impact of infection on lipid profile. Methods:A total of 30 women enrolled with symptomatic bacterial urinary tract infections and 10 healthy women as control group. Mid-stream urine samples were submitted. BMI, WC, and lipid profile were measured. Both leukocyte esterase and nitrite tests were used to diagnose the urinary tract infection, and viable quantification was done as confirmatory for the diagnosis. Results:Revealed that there was a significant relationship between the incidence of symptomatic bacterial urinary tract infections and age groups (p=0.04) as age group (21-30) years recorded the highest percentage (33.33%) followed by the age group (31-40) which recorded 30%. No significant association was found between BMI, WC and incidence of symptomatic bacterial urinary tract infections (p=0.08, p=0.14) respectively. Compared to healthy control group, there was a significant decrease in the levels of total cholesterol, triglycerides, high-density-lipoprotein, very-low-densitylipoprotein, and low-density-lipoprotein (p=0.0001, p=0.006, p=0.001, p=0.006, and p=0.0001), respectively. Conclusion:The young women were significantly susceptible to symptomatic bacterial urinary tract infections than other age groups. Both BMI and WC were not significant indicators for the incidence of symptomatic bacterial urinary tract infections in adult women. Adult women with symptomatic bacterial urinary tract infections showed a significant decrease in lipid profile parameters when compared with the control healthy adult women.

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PP-019 Plasma lipids levels in patients with acute bacterial infections

Cited by 11 publications

References 20 publications

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis

Association Between Age, Body Mass Index, Waist Circumference, Lipid Profile Parameters, and Symptomatic Bacterial Urinary Tract Infection in Iraqi Adult Women

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