POZ/BTB and AT-Hook-Containing Zinc Finger Protein 1 (PATZ1) Suppresses Progression of Ovarian Cancer and Serves as an Independent Prognosis Factor

Zhao, Cuihong; Yan, Min; Li, Chengjuan; Feng, Zhongtao

doi:10.12659/msm.908766

Cited by 4 publications

(3 citation statements)

References 31 publications

(36 reference statements)

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“…PATZ1 , containing an A–T hook DNA-binding motif, binds to other DNA-binding structures to participate in chromatin modeling and transcription regulation. PATZ1 is involved in the inhibition of the mesenchymal-to-epithelial transition via disturbing the combination between p53 gene and its response elements ( Chiappetta et al, 2015 ; Keskin et al, 2015 ) and could be an independent prognostic factor in multiple cancers ( Guadagno et al, 2017 ; Zhao et al, 2018 ; Passariello et al, 2019 ). Jun was involved in a number of biological processes that were triggered by oxidants and toxic stimuli when combined with other members of the Fos family ( Angel and Karin, 1991 ; Shaulian and Karin, 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis

Liu

Chen²,

Li³

et al. 2023

Front. Genet.

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Background: The role of alcohol in carcinogenesis has received increasing attention in recent years. Evidence shows its impacts on various aspects, including epigenetics alteration. The DNA methylation patterns underlying alcohol-associated cancers are not fully understood.Methods: We investigated the aberrant DNA methylation patterns in four alcohol-associated cancers based on the Illumina HumanMethylation450 BeadChip. Pearson coefficient correlations were identified between differential methylated CpG probes and annotated genes. Transcriptional factor motifs were enriched and clustered using MEME Suite, and a regulatory network was constructed.Results: In each cancer, differential methylated probes (DMPs) were identified, and 172 hypermethylated and 21 hypomethylated pan-cancer DMPs (PDMPs) were examined further. Annotated genes significantly regulated by PDMPs were investigated and enriched in transcriptional misregulation in cancers. The CpG island chr19:58220189–58220517 was hypermethylated in all four cancers and silenced in the transcription factor ZNF154. Various biological effects were exerted by 33 hypermethylated and seven hypomethylated transcriptional factor motifs grouped into five clusters. Eleven pan-cancer DMPs were identified to be associated with clinical outcomes in the four alcohol-associated cancers, which might provide a potential point of view for clinical outcome prediction.Conclusion: This study provides an integrated insight into DNA methylation patterns in alcohol-associated cancers and reveals the corresponding features, influences, and potential mechanisms.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis

Liu

Chen²,

Li³

et al. 2023

Front. Genet.

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“…PATZ1 expression is strongly related to cancer signatures and cellular proliferation, as recently assessed by PATZ1 ChIP-seq and gene expression microarray analyses [ 14 ]. Indeed, it has been shown to act as an oncogene in colon cancer and glioblastoma cells [ 15 , 16 , 17 , 18 ] and a tumor suppressor in glioblastoma [ 19 ], thyroid [ 20 , 21 , 22 ], ovarian [ 23 ], and liver cancer cells [ 14 ]. Additionally, PATZ1 has been proposed as a diagnostic/prognostic biomarker in different neoplasia, including testicular germ cell tumors [ 24 ], renal cell carcinoma [ 25 , 26 , 27 ], CNS neoplasms [ 28 , 29 , 30 ], round cell sarcomas [ 31 ], large cell B lymphomas [ 32 ], thyroid cancer [ 20 ], and ovarian cancer [ 23 ], where lower levels and cytoplasmic localization of the PATZ1 protein are often predictive of a more aggressive phenotype and, consequently, the worst prognosis [ 20 , 23 , 28 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

PATZ1 in Non-Small Cell Lung Cancer: A New Biomarker That Negatively Correlates with PD-L1 Expression and Suppresses the Malignant Phenotype

Luca

Franco

Napolitano

et al. 2023

Cancers

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Non-small cell lung cancer (NSCLC), the leading cause of cancer death worldwide, is still an unmet medical problem due to the lack of both effective therapies against advanced stages and markers to allow a diagnosis of the disease at early stages before its progression. Immunotherapy targeting the PD-1/PD-L1 checkpoint is promising for many cancers, including NSCLC, but its success depends on the tumor expression of PD-L1. PATZ1 is an emerging cancer-related transcriptional regulator and diagnostic/prognostic biomarker in different malignant tumors, but its role in lung cancer is still obscure. Here we investigated expression and role of PATZ1 in NSCLC, in correlation with NSCLC subtypes and PD-L1 expression. A cohort of 104 NSCLCs, including lung squamous cell carcinomas (LUSCs) and adenocarcinomas (LUADs), was retrospectively analyzed by immunohistochemistry for the expression of PATZ1 and PD-L1. The results were correlated with each other and with the clinical characteristics, showing on the one hand a positive correlation between the high expression of PATZ1 and the LUSC subtype and, on the other hand, a negative correlation between PATZ1 and PD-L1, validated at the mRNA level in independent NSCLC datasets. Consistently, two NSCLC cell lines transfected with a PATZ1-overexpressing plasmid showed PD-L1 downregulation, suggesting a role for PATZ1 in the negative regulation of PD-L1. We also showed that PATZ1 overexpression inhibits NSCLC cell proliferation, migration, and invasion, and that Patz1-knockout mice develop LUAD. Overall, this suggests that PATZ1 may act as a tumor suppressor in NSCLC.

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“…A potential oncogenic function for PATZ1 has been described in colorectal cancer [13], while it acts as a tumor suppressor in the lung [14] and thyroid [15]. Furthermore, the expression of PATZ1 has been suggested as a prognostic factor for serous ovarian carcinoma [16], diffuse large B-cell lymphomas [17], and renal cell carcinoma [18].…”

Section: Introductionmentioning

confidence: 99%

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas

Passariello

Errico

Donofrio

et al. 2019

Cancers

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Glial tumors are the leading cause of cancer-related death and morbidity in children. Their diagnosis, mainly based on clinical and histopathological factors, is particularly challenging because of their high molecular heterogeneity. Thus, tumors with identical histotypes could result in variable biological behaviors and prognoses. The PATZ1 gene has been recently shown to be expressed in adult gliomas, including glioblastomas, where it correlates with the proneural subtype and with a better prognosis. Here, we analyzed the expression of PATZ1 in pediatric gliomas, first at mRNA level in a public database, and then at protein level, by immunohistochemistry, in a cohort of 52 glial brain tumors from young patients aged from 6 months to 16 years. As for adult tumors, we show that PATZ1 is enriched in glial tumors compared to the normal brain, where it correlates positively and negatively with a proneural and mesenchymal signature, respectively. Moreover, we show that PATZ1 is expressed at variable levels in our cohort of tumors. Higher expression was detected in high-grade than low-grade gliomas, suggesting a correlation with the malignancy. Among high-grade gliomas, higher levels of PATZ1 have consistently been found to correlate with worse event-free survival. Therefore, our study may imply new diagnostic opportunities for pediatric gliomas.

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POZ/BTB and AT-Hook-Containing Zinc Finger Protein 1 (PATZ1) Suppresses Progression of Ovarian Cancer and Serves as an Independent Prognosis Factor

Cited by 4 publications

References 31 publications

Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis

Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis

PATZ1 in Non-Small Cell Lung Cancer: A New Biomarker That Negatively Correlates with PD-L1 Expression and Suppresses the Malignant Phenotype

PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas

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