POxylation as an alternative stealth coating for biomedical applications

Bludau, Herdis; Czapar, Anna E.; Pitek, Andrzej S.; Shukla, Sourabh; Jordan, Rainer; Steinmetz, Nicole F.

doi:10.1016/j.eurpolymj.2016.10.041

Cited by 87 publications

(62 citation statements)

References 45 publications

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“…Although this group did not perform circulation studies they did investigate their nanogels for induced hemolysis and erythrocyte aggregation and found no significant interaction of the nanogels with blood. Other recent studies on PEtOx modified nanoparticles and PMeOx coated viruses, each without the ability to vary the zeta potential, similarly found reduced interaction of PAOx modified materials with cells.…”

Section: Emerging Applicationsmentioning

confidence: 71%

Poly(2‐oxazoline) Hydrogels: State‐of‐the‐Art and Emerging Applications

Dargaville

Park

Hoogenboom

2018

Macromolecular Bioscience

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The synthesis of poly(2-oxazoline)s has been known since the 1960s. In the last two decades, they have risen in popularity thanks to improvements in their synthesis and the realization of their potential in the biomedical field due to their "stealth" properties, stimuli responsiveness, and tailorable properties. Even though the bulk of the research to date has been on linear forms of the polymer, they are also of interest for creating network structures due to the relatively easy introduction of reactive functional groups during synthesis that can be cross-linked under a variety of conditions. This opinion article briefly reviews the history of poly(2-oxazoline)s and examines the in vivo data on soluble poly(2-oxazoline)s to date in an effort to predict how hydrogels may perform as implantable materials. This is followed by an overview of the most recent hydrogel synthesis methods and emerging applications, and is concluded with a section on the future directions predicted for these fascinating yet underutilized polymers.

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Section: Emerging Applicationsmentioning

confidence: 71%

Poly(2‐oxazoline) Hydrogels: State‐of‐the‐Art and Emerging Applications

Dargaville

Park

Hoogenboom

2018

Macromolecular Bioscience

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“…chemotherapy delivery). To some extent, pharmacokinetics and immunogenicity of VNPs can be tailored through conjugation of a polymer stealth coating such as polyethylene glycol or polyoxazoline [18,50] or a camouflage coating such as albumin [51]. Yet newer and more modern approaches are required to make an impact in the clinic.…”

Section: Resultsmentioning

confidence: 99%

Plant viruses and bacteriophages for drug delivery in medicine and biotechnology

Czapar

Steinmetz

2017

Current Opinion in Chemical Biology

105

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There are a wide variety of synthetic and naturally occurring nanomaterials under development for nanoscale cargo-delivery applications. Viruses play a special role in these developments, because they can be regarded as naturally occurring nanomaterials evolved to package and deliver cargos. While any nanomaterial has its advantage and disadvantages, viral nanoparticles (VNPs), in particular the ones derived from plant viruses and bacteriophages, are attractive options for cargo-delivery as they are biocompatible, biodegradable, and non-infectious to mammals. Their protein-based structures are often understood at atomic resolution and are amenable to modification with atomic-level precision through chemical and genetic engineering. Here we present a focused review of the emerging technology development of plant viruses and bacteriophages targeting human health and agricultural applications. Key target areas of development are their use in chemotherapy-, photodynamic therapy-, pesticide-delivery, gene therapy, vaccine carriers, and immunotherapy.

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“…28–38 Nevertheless, as chemistries and products are being made available to wider audiences, the risk exists that these polymers are also formulated into everyday products thus leading to generation of acquired immunity against them. Furthermore, as pointed out above, the risk also exists that patients could develop antibodies after repeated exposure, as has been observed for PEG.…”

Section: Peg and Other Synthetic Polymeric Shielding Strategiesmentioning

confidence: 99%

Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications

Gulati

Stewart²,

Steinmetz³

2018

Mol. Pharmaceutics

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Nanoparticle delivery systems offer advantages over free drugs, in that they increase solubility and biocompatibility. Nanoparticles can deliver a high payload of therapeutic molecules while limiting off target side effects. Therefore, delivery of an existing drug with a nanoparticle frequently results in an increased therapeutic index. Whether of synthetic or biologic origin, nanoparticle surface coatings are often required to reduce immune clearance and thereby increase circulation times allowing the carriers to reach their target site. To this end, polyethylene glycol (PEG) has long been used, with several PEGylated products reaching clinical use. Unfortunately, the growing use of PEG in consumer products has led to an increasing prevalence of PEG-specific antibodies in the human population, which in turn has fueled the search for alternative coating strategies. This review highlights alternative bio-inspired nanoparticle shielding strategies, which may be more beneficial moving forward than PEG and other synthetic polymer coatings.

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POxylation as an alternative stealth coating for biomedical applications

Cited by 87 publications

References 45 publications

Poly(2‐oxazoline) Hydrogels: State‐of‐the‐Art and Emerging Applications

Poly(2‐oxazoline) Hydrogels: State‐of‐the‐Art and Emerging Applications

Plant viruses and bacteriophages for drug delivery in medicine and biotechnology

Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications

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