Powering Implantable and Ingestible Electronics

Yang, So Yoon; Sencadas, Vítor; You, Siheng Sean; Jia, Neil Zi Xun; Srinivasan, Shriya; Huang, Hen Wei; Ahmed, Abdelsalam; Liang, Jia Y.; Traverso, Giovanni

doi:10.1002/adfm.202009289

Cited by 75 publications

(61 citation statements)

References 446 publications

(443 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the technical side, there are high costs associated with advanced microchips, software upgrades, and clinical validation that is expected to limit the market growth of smart pills [5]. Furthermore, it is difficult to reconstruct and democratize the sensing and recording circuitry from off-the-shelf components, which limits the number of commercial ingestible capsule products [161].…”

Section: Discussion: Present Challenges and Outlookmentioning

confidence: 99%

Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

Miley

Machado

Condo

et al. 2021

Adv Devices Instrum

View full text Add to dashboard Cite

Real-time monitoring of the gastrointestinal tract in a safe and comfortable manner is valuable for the diagnosis and therapy of many diseases. Within this realm, our review captures the trends in ingestible capsule systems with a focus on hardware and software technologies used for capsule endoscopy and remote patient monitoring. We introduce the structure and functions of the gastrointestinal tract, and the FDA guidelines for ingestible wireless telemetric medical devices. We survey the advanced features incorporated in ingestible capsule systems, such as microrobotics, closed-loop feedback, physiological sensing, nerve stimulation, sampling and delivery, panoramic imaging with adaptive frame rates, and rapid reading software. Examples of experimental and commercialized capsule systems are presented with descriptions of their sensors, devices, and circuits for gastrointestinal health monitoring. We also show the recent research in biocompatible materials and batteries, edible electronics, and alternative energy sources for ingestible capsule systems. The results from clinical studies are discussed for the assessment of key performance indicators related to the safety and effectiveness of ingestible capsule procedures. Lastly, the present challenges and outlook are summarized with respect to the risks to health, clinical testing and approval process, and technology adoption by patients and clinicians.

show abstract

Section: Discussion: Present Challenges and Outlookmentioning

confidence: 99%

Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

Miley

Machado

Condo

et al. 2021

Adv Devices Instrum

View full text Add to dashboard Cite

show abstract

“…[ 1–5 ] The power unit is essential for the realization of these functions. [ 6,7 ] Due to the advantages of both high energy density and cyclability, batteries are the first choice for the power unit among various energy storage systems. [ 8,9 ] The application scenario in wearable and implantable bioelectronics thus requires matched mechanical properties (e.g., Young's moduli) of the batteries with biological tissues.…”

Section: Introductionmentioning

confidence: 99%

A Tissue‐Like Soft All‐Hydrogel Battery

Wang

Jiao

et al. 2021

Advanced Materials

View full text Add to dashboard Cite

To develop wearable and implantable bioelectronics accommodating the dynamic and uneven biological tissues and reducing undesired immune responses, it is critical to adopt batteries with matched mechanical properties with tissues as power sources. However, the batteries available cannot reach the softness of tissues due to the high Young's moduli of components (e.g., metals, carbon materials, conductive polymers, or composite materials). The fabrication of tissue‐like soft batteries thus remains a challenge. Here, the first ultrasoft batteries totally based on hydrogels are reported. The ultrasoft batteries exhibit Young's moduli of 80 kPa, perfectly matching skin and organs (e.g., heart). The high specific capacities of 82 mAh g−1 in all‐hydrogel lithium‐ion batteries and 370 mAh g−1 in all‐hydrogel zinc‐ion batteries at a current density of 0.5 A g−1 are achieved. Both high stability and biocompatibility of the all‐hydrogel batteries have been demonstrated upon the applications of wearable and implantable. This work illuminates a pathway for designing power sources for wearable and implantable electronics with matched mechanical properties.

show abstract

“…[ 1–4 ] In particular, needs emerge to extract physiological information and intervene medical events in human body, which have set off a wave of developing materials and techniques for implanted bioelectronics. [ 3,5–10 ] For instance, bioelectronic devices, such as pacemakers, neuromodulators, and wireless sensors have been developed. [ 2,11–14 ] These bioelectronic devices are designed for interfacing with soft tissues, such as deep brain, vessels, nerve, and heart.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible, High‐Performance, Wet‐Adhesive, Stretchable All‐Hydrogel Supercapacitor Implant Based on PANI@rGO/Mxenes Electrode and Hydrogel Electrolyte

Liu

Zhou

et al. 2021

Advanced Energy Materials

103

View full text Add to dashboard Cite

Functional bioelectronic implants require energy storage units as power sources. Current energy storage implants face challenges of balancing factors including high‐performance, biocompatibility, conformal adhesion, and mechanical compatibility with soft tissues. An all‐hydrogel micro‐supercapacitor is presented that is lightweight, thin, stretchable, and wet‐adhesive with a high areal capacitance (45.62 F g−1) and energy density (333 μWh cm−2, 4.68 Wh kg−1). The all‐hydrogel micro‐supercapacitor is composed of polyaniline@reduced graphene oxide/Mxenes gel electrodes and a hydrogel electrolyte, with its interfaces robustly crosslinked, contributing to efficient and stable electrochemical performance. The in vitro and in vivo biocompatibility of the all‐hydrogel micro‐supercapacitor is evaluated by cardiomyocytes and mice models. The latter is systematically conducted by performing histological, immunostaining, and immunofluorescence analysis after adhering the all‐hydrogel micro‐supercapacitor implants onto hearts of mice for two weeks. These investigations offer promising energy storage modules for bioelectronics and shed light on future bio‐integration of electronic systems.

show abstract

Powering Implantable and Ingestible Electronics

Cited by 75 publications

References 446 publications

Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

A Tissue‐Like Soft All‐Hydrogel Battery

Biocompatible, High‐Performance, Wet‐Adhesive, Stretchable All‐Hydrogel Supercapacitor Implant Based on PANI@rGO/Mxenes Electrode and Hydrogel Electrolyte

Contact Info

Product

Resources

About