Powering an Implantable Minipump with a Multi-layered Printed Circuit Coil for Drug Infusion Applications in Rodents

Givrad, Tina K.; Maarek, Jean-Michel I.; Moore, William; Holschneider, Daniel P.

doi:10.1007/s10439-009-9876-x

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…Remaining rats (MS: n=25, NMS: n=17) were implanted with a subcutaneous minipump for functional brain mapping. This self-contained minipump developed by our group, allows for bolus administration of radiotracers by remote activation for functional neuroimaging applications in freely moving, nontethered animals (Holschneider et al, 2002, Givrad et al, 2010). …”

Section: Methodsmentioning

confidence: 99%

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear

Sadler¹,

Nguyen²,

Yang³

et al. 2011

Brain Research

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Antenatal maternal stress has been shown in rodent models and in humans to result in altered behavioral and neuroendocrine responses, yet little is known about its effects on functional brain activation. Pregnant female rats received a daily foot-shock stress or sham-stress two days after testing plug-positive and continuing for the duration of their pregnancy. Adult male offspring (age 14 weeks) with and without prior maternal stress (MS) were exposed to an auditory fear conditioning (CF) paradigm. Cerebral blood flow (CBF) was assessed during recall of the tone cue in the nonsedated, nontethered animal using the 14 C-iodoantipyrine method, in which the tracer was administered intravenously by remote activation of an implantable minipump. Regional CBF distribution was examined by autoradiography and analyzed by statistical parametric mapping in the three-dimensionally reconstructed brains. Presence of fear memory was confirmed by behavioral immobility ('freezing'). Corticosterone plasma levels during the CF paradigm were measured by ELISA in a separate group of rats. Antenatal MS exposure altered functional brain responses to the fear conditioned cue in adult offspring. Rats with prior MS exposure compared to those without demonstrated heightened fear responsivity, exaggerated and prolonged corticosterone release, increased functional cerebral activation of limbic/paralimbic regions (amygdala, ventral hippocampus, insula, ventral striatum, nucleus acumbens), the locus coeruleus, and white matter, and deactivation of medial prefrontal cortical regions. Dysregulation of corticolimbic circuits may represent risk factors in the future development of anxiety disorders and associated alterations in emotional regulation.

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Section: Methodsmentioning

confidence: 99%

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear

Sadler¹,

Nguyen²,

Yang³

et al. 2011

Brain Research

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“…Many studies show that the rodents spend most of the time in a horizontal position (on their four feet) [10], [29]. Accordingly, assuming that the implant coil moves parallel to the powering coil, the power transfer efficiency changes during the movement, hence the received power level by the implantable system also changes.…”

Section: Case Study: Irpower System For Freely Moving Rodentsmentioning

confidence: 99%

A System for Wireless Power Transfer of Micro-Systems In-Vivo Implantable in Freely Moving Animals

et al. 2014

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Abstract-A system for wireless power transfer of microsystems in-vivo implantable in small animals is presented. The described solution uses a servo-controlled transmitter moved under the animal moving space. The solution minimizes the power irradiation while enabling animal speeds up to 30 cm/s. An x-y movable magnetic coil transmits the required power with a level able to keep constant the received energy. A permanent magnet on board of the implantable micro-system and an array of magnetic sensors form a coil tracking system capable of an alignment accuracy as good as 1 cm. The power is transferred over the optimized remote powering link at 13.56 MHz. The received ac signal is converted to dc voltage with a passive fullwave integrated rectifier and the voltage regulator supplies 1.8 V for the implantable sensor system. Experimental measurement on a complete prototype verifies the system performance.Index Terms-Remote powering, wireless power transfer, implantable electronics, multi-sensor system, monitoring system, implantable micro-system, servo-controlled power transfer, x-y rails, biomedical implant, system for freely moving animal, remotely powered sensor systems, in-vivo implantable system.

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“…New developments include multilayered circuit coils for powering remote sensor devices. 14 Combined components ("hybrids") consist of flexible and functional printed electronic layers. These hybrids can perform multiple functions synergistically.…”

Section: Developments In Printed Electronicsmentioning

confidence: 99%

“…Combined with implantable devices, such as insulin minipumps, remote detection capability (e.g., of glucose level) may be combined with treatment/ dosing capability (e.g., providing insulin needed) via signaling semiconductive imbedded components. 14 Powering applications can be expanded if printed coils can be printed with finer, smoother lines. [20][21][22] As components of devices become smaller, the electronics that power, respond to chemical/biochemical changes, and display/communicate results can become smaller also.…”

Section: Developments In Printed Electronicsmentioning

confidence: 99%

Future Opportunities for Advancing Glucose Test Device Electronics

Young

Joyce

et al. 2011

J Diabetes Sci Technol

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Abbreviations: (PET) polyethylene terephthalate, (pHEMA) poly-hydroxyethyl-methacrylate, (R2R) roll to roll Keywords: flexible electronics, printed biosensors, printed electronics, printed sensing system, roll to roll, rotogravure AbstractAdvancements in the field of printed electronics can be applied to the field of diabetes testing. A brief history and some new developments in printed electronics components applicable to personal test devices, including circuitry, batteries, transmission devices, displays, and sensors, are presented. Low-cost, thin, and lightweight materials containing printed circuits with energy storage or harvest capability and reactive/display centers, made using new printing/imaging technologies, are ideal for incorporation into personal-use medical devices such as glucose test meters. Semicontinuous rotogravure printing, which utilizes flexible substrates and polymeric, metallic, and/or nano "ink" composite materials to effect rapidly produced, lower-cost printed electronics, is showing promise. Continuing research advancing substrate, "ink," and continuous processing development presents the opportunity for research collaboration with medical device designers.

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Powering an Implantable Minipump with a Multi-layered Printed Circuit Coil for Drug Infusion Applications in Rodents

Cited by 9 publications

References 10 publications

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear

A System for Wireless Power Transfer of Micro-Systems In-Vivo Implantable in Freely Moving Animals

Future Opportunities for Advancing Glucose Test Device Electronics

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