Power-Up for Mucoadhesiveness: Two Generations of Thiolated Surfactants for Enhanced Sticky Nanoemulsions
Dennis To,
Gergely Kali,
Soheil Haddadzadegan
et al.
Abstract:Nanoemulsions can
be tuned toward enhanced gastro-intestinal retention
time by incorporating thiolated surfactants into their surface. Tailoring
the chemical reactivity of the thiol headgroup has major influence
on mucoadhesive features of the nanoemulsion. Two generations of thiolated
surfactants were synthetically derived from PEG-40-stearate featuring
either a free thiol group or an S-protected thiol group. The surfactants
were characterized regarding critical micelle concentration (CMC),
hemolytic activity… Show more
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