Power spectral analysis of short-term RR interval and arterial blood pressure oscillations in lizard (Gallotia galloti): Effects of parasympathetic blockade

Vera, Luis De; González, José M.

doi:10.1016/s0300-9629(96)00463-x

Cited by 15 publications

(12 citation statements)

References 19 publications

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“…The control-resting R-R interval values reported for G. galloti in this research, and the R-R interval values under cholinoceptor, and ␣ 1 -and ␤-adrenoceptor blockades are in accordance with values obtained by the authors in previous studies (8,9). As far as the authors know, the effect of the ␣ 2 -adrenoceptor blockade with yohimbine on the R-R interval value in a reptilian species is reported here for the first time, which means there are no data from other reptiles for comparison.…”

Section: Discussionsupporting

confidence: 92%

“…This would imply that, in lizards in the basal state, the cholinergic, ␣ 1 -, ␣ 2 -, and ␤-adrenergic activities act separately, without interacting with each other when modulating the R-R interval durations. A possible explanation for this linear behavior is founded on the fact that cardiac period oscillations in G. galloti are mainly mediated by cholinergic activity as previous studies have shown (8,9). The role of the vagal activity in RRV modulation is so preponderant in this animal that the adrenergic activities, which are also involved in RRV modulation, although with a much lower participation, would not need to consequently exchange information between one another, and even much less so with vagal activity, to accomplish their comparatively simpler task.…”

Section: Rrv Dynamics From a Nonlinear Technique Point Of Viewmentioning

confidence: 86%

“…Nevertheless, few studies applying classical methods to investigate the role of the ANS in the short-term cardiac control have been performed on reptiles (4,36,40). In this respect, previous investigations using Fourier analysis and pharmacological blockade (8,9), have shown that the R-R interval low-frequency oscillations in the lizard Gallotia galloti appear to be powered by both ␣ 1 -adrenergic and cholinergic activities and buffered by ␤-adrenergic activity.…”

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confidence: 99%

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Nonlinearity and fractality in the variability of cardiac period in the lizard,Gallotia galloti: effects of autonomic blockade

Vera¹,

Santana²,

González³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Both nonlinear and fractal properties of beat-to-beat R-R interval variability signal (RRV) of freely moving lizards (Gallotia galloti) were studied in baseline and under autonomic nervous system blockade. Nonlinear techniques allowed us to study the complexity, chaotic behavior, nonlinearity, stationarity, and regularity over time of RRV. Scaling behavior of RRV was studied by means of fractal techniques. The autonomic nervous system blockers used were atropine, propranolol, prazosin, and yohimbine. The nature of RRV was linear in baseline and under beta-, alpha(1)- and alpha(2)-adrenoceptor blockades. Atropine changed the linear nature of RRV to nonlinear and increased its stationarity, regularity and fractality. Propranolol increased the complexity and chaotic behavior, and decreased the stationarity, regularity, and fractality of RRV. Both prazosin and yohimbine did not change any of the nonlinear and fractal properties of RRV. It is suggested that 1) the use of both nonlinear and fractal analysis is an appropriate approach for studying cardiac period variability in reptiles; 2) the cholinergic activity, which seems to make the alpha(1)-, alpha(2)- and beta-adrenergic activity interaction unnecessary, determines the linear behavior in basal RRV; 3) fractality, as well as both RRV regularity and stationarity over time, may result from the balance between cholinergic and beta-adrenergic activities opposing actions; 4) beta-adrenergic activity may buffer both the complexity and chaotic behavior of RRV, and 5) neither the alpha(1)- nor the alpha(2)-adrenergic activity seem to be involved in the mediation of either nonlinear or fractal components of RRV.

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Section: Discussionsupporting

confidence: 92%

Section: Rrv Dynamics From a Nonlinear Technique Point Of Viewmentioning

confidence: 86%

mentioning

confidence: 99%

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Nonlinearity and fractality in the variability of cardiac period in the lizard,Gallotia galloti: effects of autonomic blockade

Vera¹,

Santana²,

González³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…So far, the study of the autonomic mediation of the interaction between beat-to-beat RRI and ABP variability signals in lizards has been carried out only by linear methods. This research suggested a possible involvement of the parasympathetic limb of the baroreflex in maintaining the coherence between variability signals in the low-frequency band (De Vera and González 1997).…”

mentioning

confidence: 70%

“…The use of time series analysis techniques to study interdependence between beat-to-beat fluctuations of RRI and ABP in pharmacological treatment experiments has contributed to a deeper understanding of the cardiovascular autonomic control in tetrapod vertebrates (Cerutti et al 1994;Zwiener et al 1996;De Vera and González 1997;Cohen and Taylor 2002;González and Pereda 2004;Seebacher and Franklin 2004;Pereda et al 2005a;Beckers et al 2006;Porta et al 2006). Collectively, these studies analyze the autonomic regulation of the complex mutual influence of cardiac and vascular activities by using signal analysis methods based on the linear and (or) nonlinear systems theories.…”

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confidence: 99%

Autonomic mediation of the interdependence between variability signals of heart rate and blood pressure in the lizard Gallotia galloti

et al. 2012

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Autonomic nervous system (ANS) involvement in the mediation of the synchronization between beat-to-beat RR interval variability (RRIV) and systolic blood pressure variability (SBPV) signals of the lizard Gallotia galloti (Oudart, 1839) was investigated through linear and nonlinear time series analysis methods in a pharmacological blockade context. The ANS blockers used were atropine, prazosin, and propranolol. The interdependence between the signals was quantified by means of the magnitude-squared coherence (MSC), which measures amplitude and phase linear synchronization; the phase lag index (PLI), which evaluates the phase synchronization; and the index L, which quantifies the generalized linear and nonlinear synchronization. Atropine decreased the PLI in the low-frequency (LF: 0.01-0.05 Hz) range; prazosin decreased the MSC in the medium-frequency (MF: 0.06-0.15 Hz) range; and propranolol did not alter any of the interdependence measures. It is suggested that (i) the cholinoceptor activity mediates the phase cardiovascular synchronization in the LF range; (ii) the a1-adrenoceptor activity mediates the amplitude and phase linear cardiovascular synchronization in the MF range; and (iii) the b-adrenoceptor activity plays no role in mediating any dynamics of cardiovascular synchronization in the studied frequency range. When comparing these results with those in mammals, a lesser overall autonomic involvement in the mediation of the studied cardiovascular interdependences is seen in reptiles.Résumé : Des méthodes d'analyse linéaire et non linéaire de séries temporelles ont été utilisées pour étudier le rôle du système nerveux autonome (SNA) dans la médiation de la synchronisation des signaux de variabilité des intervalles RR décalés d'un battement (RRIV) et de la pression sanguine systolique (SBPV) chez le lézard Gallotia galloti Oudart, 1839 dans un contexte de blocage pharmacologique. Les inhibiteurs du SNA utilisés sont l'atropine, la prazonine et le propranolol. L'interdépendance entre les signaux a été quantifiée au module de la fonction de cohérence (MSC), une mesure de la synchronisation linéaire amplitude et phase, de l'indice de déphasage (PLI), une mesure de la synchronisation de phases, et de l'indice L, qui quantifie la synchronisation linéaire et non linéaire généralisée. L'atropine a entraîné une diminution du PLI à basse fréquence (0,01-0,05 Hz) et la prazosine, une diminution du MSC à fréquence intermédiaire (0,06-0,15 Hz), alors que le propranolol n'a eu aucun effet sur les mesures de l'interdépendance. Il est suggéré que (i) l'activité de cholinocepteurs joue un rôle dans la médiation de la synchronisation cardiovasculaire de phases à basse fréquence, (ii) l'activité de l'adrénocep-teur a 1 intervient dans la médiation de la synchronisation cardiovasculaire linéaire de l'amplitude et de la phase à fréquence intermédiaire et (iii) l'activité de l'adrénocepteur b n'intervient dans la médiation d'aucun aspect de la synchronisation cardiovasculaire dans la fourchette de fréquences étudiée. La comparai...

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Power spectral analysis of short-term RR interval and arterial blood pressure oscillations in the lizard,Gallotia galloti: Effects of sympathetic blockade

Vera

González

1999

J. Exp. Zool.

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Power spectral analysis of short-term RR interval and arterial blood pressure oscillations in lizard (Gallotia galloti): Effects of parasympathetic blockade

Cited by 15 publications

References 19 publications

Nonlinearity and fractality in the variability of cardiac period in the lizard,Gallotia galloti: effects of autonomic blockade

Nonlinearity and fractality in the variability of cardiac period in the lizard,Gallotia galloti: effects of autonomic blockade

Autonomic mediation of the interdependence between variability signals of heart rate and blood pressure in the lizard Gallotia galloti

Power spectral analysis of short-term RR interval and arterial blood pressure oscillations in the lizard,Gallotia galloti: Effects of sympathetic blockade

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