Power spectral analysis in infants with seizures: Relationship to development

Kulandaivel, Kandan; Holmes, Gregory L.

doi:10.1016/j.yebeh.2011.02.021

Cited by 17 publications

(15 citation statements)

References 30 publications

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“…For example, in a study of 95 children with epilepsy (mean age = 10.41 years) who had both EEGs and neuropsychological batteries performed, Koop et al [35] showed that the presence of slow-wave activity, but not epileptiform activity, was related to memory impairment (p < 0.01). In a study of PSA in 200 infants between 6-24 months of age who were evaluated for seizures it was found that compared with the normal infants, children with developmental delay had lower mean frequencies and greater delta and less theta and alpha power [33]. In DS presence or absence of alpha activity was statistically related to whether the patient had severe or less severe mental deficits [36].…”

Section: Discussionmentioning

confidence: 99%

“…As Scn1a plays a role in brain oscillations and alterations in brain oscillation patterns have been associated with developmental delay [33]), we hypothesized that children with DS would have altered brain oscillations when compared to similarly aged children without DS. A secondary hypothesis was that with age, oscillatory patterns in children with DS would maturate differently from controls and parallel the deterioration in cognitive abilities.…”

Section: Introductionmentioning

confidence: 99%

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Maturation of EEG oscillations in children with sodium channel mutations

Holmes

Bender

et al. 2012

Brain and Development

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Dravet syndrome (DS) is a severe epileptic encephalopathy beginning in infancy in which children have difficult to control seizures and cognitive impairment. The majority of children with DS carry mutate,ons of the gene Scn1a, which codes for the alpha subunit of the type 1 voltage-gated sodium channel and is important for the function of interneurons. Interneurons have a critical role in the generation of brain rhythms involved in cognitive processing. We hypothesized that children with DS with Scn1a mutations would have abnormal oscillatory activity. To address this hypothesis, we used EEG power spectral analysis during the wakening to determine if frequency and power are altered in 23 EEGs from 12 children with DS compared to 18 age-matched controls. While there were few differences between the EEG power spectra in DS and controls in children under 2 years, in older children group differences were apparent. In DS children between 3-5 years there were significant decreases in percentage of alpha power compared to controls and in DS children over age 6 years there was a marked increase of theta and decrease of alpha compared to controls. Developmental status paralleled the power spectral analysis with an increasing likelihood of having severe cognitive problems with increasing age. These results demonstrate that Scn1a mutations result in an age-dependent alteration in oscillatory process. Such abnormalities in developmental progression of oscillations may play an important role in poor cognitive development in children with DS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maturation of EEG oscillations in children with sodium channel mutations

Holmes

Bender

et al. 2012

Brain and Development

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“…Development of the oscillatory structure of spontaneous brain activity is related to child development [1,28], including during the perinatal period that corresponds to premature birth [49]. Such ratio-based techniques have been successfully employed by previous studies of the maturation of functional brain activity during childhood [8,28] and its alteration in clinical child populations [1,9,34,43]. In particular, alterations of the ratio between high- and low-frequency oscillations has been reported in young adults born at extremely low birth weight [43].…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, we compared long-term effects of pain in children born at ELGA compared to those born at VLGA. The spectral structure of cortical oscillations, expressed in power ratios among oscillations in different frequency ranges, develops throughout childhood [8,28] and is altered in at-risk children [1,9,34]. Young adults born at extremely low birth weight display an atypical ratio of low- to high-frequency power in resting brain rhythms [43], likely reflecting the development of functional brain activity as alpha- and gamma-band oscillations, which are understood to play reciprocal roles in cognition and perception [12,15,22,26, 29,30,39,51].…”

Section: Introductionmentioning

confidence: 99%

Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age

Doesburg

Chau

Cheung

et al. 2013

Pain

222

124

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Children born very prematurely (≤32 weeks) often exhibit visual-perceptual difficulties at school-age, even in the absence of major neurological impairment. The alterations in functional brain activity that give rise to such problems, as well as the relationship between adverse neonatal experience and neurodevelopment, remain poorly understood. Repeated procedural pain-related stress during neonatal intensive care has been proposed to contribute to altered neurocognitive development in these children. Due to critical periods in the development of thalamocortical systems, the immature brain of infants born at extremely low gestational age (ELGA; ≤28 weeks) may have heightened vulnerability to neonatal pain. In a cohort of school-age children followed since birth we assessed relations between functional brain activity measured using magnetoencephalogragy (MEG), visual-perceptual abilities and cumulative neonatal pain. We demonstrated alterations in the spectral structure of spontaneous cortical oscillatory activity in ELGA children at school-age. Cumulative neonatal pain-related stress was associated with changes in background cortical rhythmicity in these children, and these alterations in spontaneous brain oscillations were negatively correlated with visual-perceptual abilities at school-age, and were not driven by potentially confounding neonatal variables. These findings provide the first evidence linking neonatal painrelated stress, the development of functional brain activity, and school-age cognitive outcome in these vulnerable children.

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“…Recent application of graph theoretical analysis has also revealed that network properties of functional connectivity are abnormal in epileptic cortex and that these areas are functionally disconnected from other brain regions [19], [21], [22]. Despite convergent evidence implicating network connectivity in cognitive, perceptual and motor function, their impairments in clinical populations, and recent findings linking oscillatory power to functional difficulties in epilepsy [23], the relationship between oscillatory synchrony and functional deficits in epilepsy remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Disruption of Rolandic Gamma-Band Functional Connectivity by Seizures is Associated with Motor Impairments in Children with Epilepsy

et al. 2012

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Although children with epilepsy exhibit numerous neurological and cognitive deficits, the mechanisms underlying these impairments remain unclear. Synchronization of oscillatory neural activity in the gamma frequency range (>30 Hz) is purported to be a mechanism mediating functional integration within neuronal networks supporting cognition, perception and action. Here, we tested the hypothesis that seizure-induced alterations in gamma synchronization are associated with functional deficits. By calculating synchrony among electrodes and performing graph theoretical analysis, we assessed functional connectivity and local network structure of the hand motor area of children with focal epilepsy from intracranial electroencephalographic recordings. A local decrease in inter-electrode phase synchrony in the gamma bands during ictal periods, relative to interictal periods, within the motor cortex was strongly associated with clinical motor weakness. Gamma-band ictal desychronization was a stronger predictor of deficits than the presence of the seizure-onset zone or lesion within the motor cortex. There was a positive correlation between the magnitude of ictal desychronization and impairment of motor dexterity in the contralateral, but not ipsilateral hand. There was no association between ictal desynchronization within the hand motor area and non-motor deficits. This study uniquely demonstrates that seizure-induced disturbances in cortical functional connectivity are associated with network-specific neurological deficits.

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Power spectral analysis in infants with seizures: Relationship to development

Cited by 17 publications

References 30 publications

Maturation of EEG oscillations in children with sodium channel mutations

Maturation of EEG oscillations in children with sodium channel mutations

Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age

Disruption of Rolandic Gamma-Band Functional Connectivity by Seizures is Associated with Motor Impairments in Children with Epilepsy

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