Power spectra of arterial pressure and heart rate in streptozotocin-induced diabetes in rats

Fazan, Rubens; Vj, Dias da Silva; Ballejo, Gustavo; Hc, Salgado

doi:10.1097/00004872-199917040-00006

Cited by 51 publications

(52 citation statements)

References 31 publications

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“…[11][12][13][14][15] These methods are able to detect early abnormalities in the autonomic modulation of the cardiovascular system. [16][17][18][19] When evaluated in the time domain, the heart rate variability was reduced in chronic STZ-diabetic rats. 12,20 In another study, Fazan et al 19 observed reduction in the arterial pressure (AP) and heart rate (HR) variability, measured either as the standard deviation or by spectral analysis in chronic STZ-diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18][19] When evaluated in the time domain, the heart rate variability was reduced in chronic STZ-diabetic rats. 12,20 In another study, Fazan et al 19 observed reduction in the arterial pressure (AP) and heart rate (HR) variability, measured either as the standard deviation or by spectral analysis in chronic STZ-diabetic rats. In humans with DM, spectral analysis of HR disclosed significant changes in the cardiovascular variability in the frequency domain, which were apparent even before changes in all other standard cardiovascular parameters.…”

Section: Introductionmentioning

confidence: 99%

“…17 Administration of STZ is a well-established method to induce diabetes in rodents, 21 producing a number of cardiovascular changes such as hypotension, bradycardia, decreased AP variability, and impairment of the reflex control of circulation. 4,19,22,23 Since the administration of STZ to Wistar rats induces a diabetic state that is not accompanied by hypertension, 11 its use in spontaneously hypertensive rats (SHR) can produce an animal model more closely related to human diabetes. Therefore, the aim of the present study was to evaluate the autonomic modulation of the cardiovascular function in STZ-induced diabetic SHR, by studying the blood pressure and heart rate variability in the time and frequency domains (spectral analysis), and also evaluating the cardiac baroreflex sensitivity in this model.…”

Section: Introductionmentioning

confidence: 99%

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Autonomic Modulation of Arterial Pressure and Heart Rate Variability in Hypertensive Diabetic Rats

Farah

Angelis

Joaquim

et al. 2007

Clinics

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modulation of arterial pressure and heart rate variability in hypertensive diabetic rats. Clinics. 2007;62(4):477-82. OBJECTIVE:The aim of the present study was to evaluate the autonomic modulation of the cardiovascular system in streptozotocin (STZ)-induced diabetic spontaneously hypertensive rats (SHR), evaluating baroreflex sensitivity and arterial pressure and heart rate variability. METHODS: Male SHR were divided in control (SHR) and diabetic (SHR+DM, 5 days after STZ) groups. Arterial pressure (AP) and baroreflex sensitivity (evaluated by tachycardic and bradycardic responses to changes in AP) were monitored. Autoregressive spectral estimation was performed for systolic AP (SAP) and pulse interval (PI) with oscillatory components quantified as low (LF:0.2-0.6Hz) and high (HF:0.6-3.0Hz) frequency ranges. RESULTS: Mean AP and heart rate in SHR+DM (131±3 mmHg and 276±6 bpm) were lower than in SHR (160±7 mmHg and 330±8 bpm). Baroreflex bradycardia was lower in SHR+DM as compared to SHR (0.55±0.1 vs. 0.97±0.1 bpm/mmHg). Overall SAP variability in the time domain (standard deviation of beat-by-beat time series of SAP) was lower in SHR+DM (3.1±0.2 mmHg) than in SHR (5.7±0.6 mmHg). The standard deviation of the PI was similar between groups. Diabetes reduced the LF of SAP (3.3±0.8 vs. 28.7±7.6 mmHg2 in SHR), while HF of SAP were unchanged. The power of oscillatory components of PI did not differ between groups. CONCLUSIONS: These results show that the association of hypertension and diabetes causes an impairment of the peripheral cardiovascular sympathetic modulation that could be, at least in part, responsible for the reduction in AP levels. Moreover, this study demonstrates that diabetes might actually impair the reduced buffer function of the baroreceptors while reducing blood pressure.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Autonomic Modulation of Arterial Pressure and Heart Rate Variability in Hypertensive Diabetic Rats

Farah

Angelis

Joaquim

et al. 2007

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“…Remarkable autonomic dysfunction, particularly concerning the baroreflex, has been well described not only in diabetic patients (2,3), but also in chronic experimental models of diabetes (4,5,30). Short-term (5 days) diabetes also exhibited a dysfunction of the baroreflex in rats (7).…”

Section: Perspectivesmentioning

confidence: 99%

“…Dysfunction of the baroreflex has been well described not only in diabetic patients (2,3) and chronic models of diabetes (4)(5)(6), but also in short-term (5 days) experimental diabetes (7). Even though modest elevations of plasma glucose are associated with reduction of reflex control of heart rate in healthy volunteers (8,9), there is no report in the literature dealing with the acute effects of elevated blood glucose on the afferent arm (baroreceptors) of the arterial baroreflex in non-diabetic subjects.…”

Section: Introductionmentioning

confidence: 99%

Does acute hyperglycemia alter rat aortic depressor nerve function?

Huber

Carmo

Castania

et al. 2007

Braz J Med Biol Res

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Because it is not known where in the reflex arch, i.e., afference, central nervous system or efferences, hyperglycemia affects baroreflex function, the present study examined the effect of short-term (30 min) hyperglycemia on aortic depressor nerve function measured by a mean arterial pressure vs aortic depressor nerve activity curve, fitted by sigmoidal regression, or by cross-spectral analysis between mean arterial pressure and aortic depressor nerve activity. Anesthetized male Wistar rats received an intravenous bolus (0.25 mL) injection, followed by 30 min of infusion (1 mL/h) of 30% glucose (N = 14). Control groups received a bolus injection and infusion of 0.9% saline (N = 14), or 30% mannitol (N = 14). Glucose significantly increased both blood glucose and plasma osmolarity (P < 0.05). Mean arterial pressure did not change after glucose, saline or mannitol infusion. Mean arterial pressure vs nerve activity curves were identical before and 10 and 30 min after the beginning of glucose, saline or mannitol infusion. Slow (0.3 Hz) oscillations of arterial pressure were induced by controlled bleeding, and cross-spectral analysis was applied to arterial pressure and aortic nerve activity. Transfer function magnitude (aortic depressor nerve activity/mean arterial pressure ratio in the frequency domain) was calculated as an index of gain of the aortic depressor nerve. Transfer function magnitude was similar in all groups during induced or spontaneous oscillations of arterial pressure. In conclusion, the present study demonstrates, by means of two different approaches for assessing baroreceptor function, that aortic depressor nerve activity was not altered by short-term (30 min) hyperglycemia.

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Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus

et al. 2011

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Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that can be found in almost all postnatal organs and tissues. The main functional characteristics of MSCs are their immunomodulatory ability, capacity for self-renewal, and differentiation into mesodermal tissues. The ability of MSCs to differentiate into several cell types, including muscle, brain, vascular, skin, cartilage, and bone cells, makes them attractive as therapeutic agents for a number of diseases including complications of diabetes mellitus. We review here the potential of MSCs as new therapeutic agents in the treatment of diabetic cardiomyopathy, diabetic nephropathy, diabetic polyneuropathy, diabetic retinopathy, and diabetic wounds. Also, in this review we discuss the current limitations for MSCs therapy in humans. Stem Cells 2011;29:5–10

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Power spectra of arterial pressure and heart rate in streptozotocin-induced diabetes in rats

Abstract: Our findings that the mid-frequency band variability of arterial pressure was reduced in diabetic patients suggest that sympathetic modulation of the cardiovascular system is impaired, corroborating other studies in such patients using this and other approaches.

Cited by 51 publications

References 31 publications

Autonomic Modulation of Arterial Pressure and Heart Rate Variability in Hypertensive Diabetic Rats

Autonomic Modulation of Arterial Pressure and Heart Rate Variability in Hypertensive Diabetic Rats

Does acute hyperglycemia alter rat aortic depressor nerve function?

Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus

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