Abstract:Epidemiologists often categorize exposures based on quantiles of exposure and use the Cochran-Armitage trend test based on such categories to detect associations between disease and exposure. Power calculations typically assume that the population quantiles are known, but in practice quantiles are often estimated from the sample data. We evaluated the power of the Cochran-Armitage trend test for cohort designs and for case-control designs in which sample quantiles of exposure in the cohort or in controls from … Show more
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