Power Doppler Ultrasound in Musculoskeletal Disease: A Systematic Review

Joshua, Fredrick; Edmonds, John; Lassere, Marissa

doi:10.1016/j.semarthrit.2006.04.009

Cited by 74 publications

(51 citation statements)

References 54 publications

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“…Over the past few years, there has been increasing use of musculoskeletal US with CD or PD techniques for detecting and monitoring joint inflammatory activity in patients with RA (2,42,43). For this study, a large cohort of RA patients who were starting anti-TNF treatment was investigated longitudinally.…”

Section: Discussionmentioning

confidence: 99%

“…The greater resolution of superficial musculoskeletal structures offered with the use of highfrequency transducers, along with the higher sensitivity of current color Doppler (CD) and power Doppler (PD) ultrasonography (US) techniques for detecting synovial vascularization, have led to increasing use of US in rheumatic diseases (2). This technique is a routinely available, noninvasive, and relatively inexpensive bedside imaging modality with high patient acceptability, which allows the scanning of all peripheral joints as many times as required.…”

Section: Conclusion These Findings Indicate That Pdus Is a Valid Metmentioning

confidence: 99%

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Power doppler ultrasonographic monitoring of response to anti–tumor necrosis factor therapy in patients with rheumatoid arthritis

Naredo

Möller²,

Cruz

et al. 2008

Arthritis & Rheumatism

237

151

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Objective. To evaluate the validity, responsiveness, and predictive value of power Doppler ultrasonography (PDUS) monitoring of response to tumor necrosis factor (TNF) blocking agents in rheumatoid arthritis (RA).Methods. Three hundred sixty-seven RA patients were prospectively recruited at 25 Spanish centers; complete clinical, laboratory, and PDUS data were obtained on 278 patients. The patients underwent clinical, laboratory, and PDUS assessment at baseline and after 1, 3, 6, and 12 months of anti-TNF treatment, and radiographic assessment of the hands and feet at baseline and 12 months. The Disease Activity Score in 28 joints (DAS28) was recorded at each visit. PDUS examination included 86 intraarticular and periarticular sites in 28 joints. US synovial fluid (SF), synovial hypertrophy (SH), and PD signal were scored in all synovial sites. US count and index for SF, SH, and PD signal were obtained. Sensitivity to change of the PDUS variables was assessed by estimating the smallest detectable difference (SDD) from the intraobserver variability.Results. A significant parallel improvement in DAS28 and PDUS parameters was found at followup assessment (P < 0.0005 for within-subject between-visit changes). The SDD for PDUS parameters was lower than the mean changes throughout followup. Timeintegrated values of US joint count for PD signal and rheumatoid factor (RF) showed predictive value in relation to progression of radiographic erosion (R ‫؍‬ 0.64), and time-integrated values of US joint count for PD signal, RF, and erythrocyte sedimentation rate were predictors of progression of the total radiographic score (R ‫؍‬ 0.59).Conclusion. These findings indicate that PDUS is a valid method for monitoring response to anti-TNF therapy in RA; results obtained by PDUS are reproducible and sensitive to change. PDUS findings may have predictive value in relation to radiologic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Conclusion These Findings Indicate That Pdus Is a Valid Metmentioning

confidence: 99%

Power doppler ultrasonographic monitoring of response to anti–tumor necrosis factor therapy in patients with rheumatoid arthritis

Naredo

Möller²,

Cruz

et al. 2008

Arthritis & Rheumatism

237

151

View full text Add to dashboard Cite

show abstract

“…Two other recent systematic reviews had previously examined the validity of US as an outcome measure according to the basic components of the OMERACT filter, demonstrating that most of the work undertaken so far has considered inflammatory arthritis, and only a few manuscripts pertained to either synovitis or Doppler modalities in OA [13,14]. Keen and colleagues, after analysing all published literature which used sonography to assess joint changes in patients with OA, underline that more work is needed to develop standardised definitions of pathology and to demonstrate the validity of sonography in OA [12].…”

Section: Literature Reviewmentioning

confidence: 99%

“…On the contrary, it has been applied to the study of osteoarthritis (OA) less frequently [9][10][11][12]. This issue has been reported in recent reviews that have analysed the published data on the validity of US in assessing inflammatory aspects of rheumatic disorders, underlining the fact that that only a few studies have been undertaken in the field of OA so far [12][13][14]. Most of these publications refer to the evaluation of synovitis and power Doppler signal, analysing different components of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) filter in rheumatoid arthritis and, in a minority of cases, in OA [12].…”

mentioning

confidence: 99%

Imaging the joint in osteoarthritis: a place for ultrasound?

Iagnocco

2010

Best Practice & Research Clinical Rheumatology

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Ultrasound (US) is a valuable tool for imaging musculoskeletal changes in osteoarthritis. It shows early and late findings related to inflammation and structural damage. Sonography is a safe tool, which has recently registered an increasing and widespread use, it being considered as a bedside procedure in the clinical assessment of rheumatic patients. Its applications in osteoarthritis are related to easy accessibility of equipment, low cost, short duration of single examinations and the possibility of performing a multiregional joint evaluation in the same scanning session. Permitting an extensive evaluation of most joint changes present in osteoarthritis, it gives the opportunity to monitor disease progression and perform a follow-up of the response to different local and systemic treatments. US-guided procedures are commonly performed with safety, reliability and optimal patient tolerance. Development in technology and technique with improvement of new research studies will further amplify the diagnostic role of ultrasound in osteoarthritis in the near future. (C) 2009 Elsevier Ltd. All rights reserved

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“…The mean EDV was 4.5 cm/sec (range 1-15) in the melanoma group and 7.1 cm/sec (range [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] in the metastases group (p=0.11). The mean PSV was 12.9 cm/sec (range 3-36) in the melanoma group and 19.1 cm/sec (range 5-57) in the metastases group (p=0.25).…”

Section: Resultsmentioning

confidence: 99%

Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases

Neudorfer

Waisbourd²,

Anteby³

et al. 2010

Oncol Rep

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Abstract. The objective of this study was to characterize and differentiate vascular patterns of choroidal melanomas and choroidal metastases by color flow mapping (CFM). We conducted a retrospective chart study on CFM findings in 18 patients with choroidal melanomas and 10 patients with choroidal metastases. We evaluated the possibilities of applying CFM to identify hypo-versus hyper-vascularity within the tumor, a central 'dominant vessel', and Doppler signals in the tumor's center and/or periphery. CFM demonstrated hypervascular patterns in 33% melanomas and 100% metastases (p<0.0001). CFM identified a central dominant vessel in 94% melanomas and 0/10 metastases (p<0.0001). Vascularity occupied the center of 11/18 melanomas and 0/10 metastases (p<0.0001), the periphery of 2/18 melanomas and 9/10 metastases (p<0.0001), and equally occupied the tumor's center and periphery of 5/18 melanomas and 1/10 metastases (p<0.0001). Based on our findings, we conclude that CFM was capable of non-invasively demonstrating different and distinct vascular patterns in malignant choroidal melanomas and choroidal metastases.

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Power Doppler Ultrasound in Musculoskeletal Disease: A Systematic Review

Cited by 74 publications

References 54 publications

Power doppler ultrasonographic monitoring of response to anti–tumor necrosis factor therapy in patients with rheumatoid arthritis

Power doppler ultrasonographic monitoring of response to anti–tumor necrosis factor therapy in patients with rheumatoid arthritis

Imaging the joint in osteoarthritis: a place for ultrasound?

Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases

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