Power Doppler ultrasound assessment of ovarian perifollicular blood flow in women with polycystic ovaries and normal ovaries during in vitro fertilization treatment

Costello, Michael; Shrestha, Sanu M.; Sjöblom, Peter; McNally, Glenn; Bennett, Michael J.; Steigrad, Stephen J.; Hughes, Graeme J.

doi:10.1016/j.fertnstert.2004.09.025

Cited by 14 publications

(5 citation statements)

References 42 publications

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“…In our study, there were no significant differences noted in the 3D power Doppler indices between the two ovaries. The ultrasound scans were performed in the early follicular phase when the population of follicles in the ovary is predominantly antral follicles, and therefore perhaps no difference was noted in vascularity (62). However, this may not be consistent in different phases of the menstrual cycle as the growing follicle and corpus luteum acquire a larger blood supply (63).…”

Section: Figurementioning

confidence: 99%

The interovarian variation in three-dimensional ultrasound markers of ovarian reserve in women undergoing baseline investigation for subfertility

Deb

Jayaprakasan

Campbell

et al. 2011

Fertility and Sterility

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Section: Figurementioning

confidence: 99%

The interovarian variation in three-dimensional ultrasound markers of ovarian reserve in women undergoing baseline investigation for subfertility

Deb

Jayaprakasan

Campbell

et al. 2011

Fertility and Sterility

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“…12,57,59 In contrast to the increased blood flow observed in the ovarian stroma of women with PCO/PCOS, the perifollicular blood flow in women with PCO was found to be either lower 64 or no different than in women with normal ovaries. 65 Moreover, Palomba et al reported that perifollicular blood flow was similar between women with PCOS treated with metformin and non-PCOS controls, but significantly lower in women with PCOS treated with clomiphene citrate as compared with the other two groups. 66 Taken together, these data suggest that the follicular angiogenic milieu may be different than the stromal one in the PCO.…”

Section: Evidence For Abnormal Vascularization In the Polycystic Ovarymentioning

confidence: 98%

The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome

2015

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Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in reproductive age affecting 5 to 7% of women. It is characterized by anovulatory infertility, hyperandrogenism, and polycystic ovaries. Angiogenesis in the ovary is critical for follicular growth, ovulation, and the subsequent development and regression of the corpus luteum. Accumulating evidence suggests that multiple angiogenic factors are dysregulated in PCOS, including vascular endothelial growth factor, angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. This angiogenic factor imbalance likely underlies the increased stromal vascularity observed in PCOS. Angiogenic factor dysregulation may play an important role in the pathophysiology of PCOS and may contribute to ovulatory dysfunction, subfertility, and ovarian hyperstimulation syndrome, which are commonly seen in women with PCOS. Further experimental studies are needed to gain a better understanding of the growth factors that are involved in normal and pathological ovarian angiogenesis, and to assess the potential of angiogenesis-based treatment strategies in PCOS.

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“…Following IVF, it was found that oocyte from well vascularized follicles are the best to achieve higher pregnancy rates. This is evidently related to the importance of angiogenesis during early development (2) .…”

Section: Introductionmentioning

confidence: 96%

“…n: number of cases; SD: standard deviation; O: one way ANOVA; C: chi-square test; NS: not significant; *: significant at p ≤ 0.05 Table(2) showed that there was no significant difference in cycle day 2 serum FSH and LH hormonal levels among study groups (p > 0.05). also, there was no significant difference in mean serum estradiol (E2), TSH and AMH (p > 0.05).…”

mentioning

confidence: 97%

Effectiveness of Low Dose Aspirin or Vaginal Sildenafil on Perifollicular Blood Flow Using Doppler ultrasound and EG-VEGF and their Impacts on ICSI Cycle Outcome

Mohammed¹,

Hussaini²,

ALjubori³

2022

The Egyptian Journal of Hospital Medicine

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Background: Aspirin low dose or vaginal sildenafil, the two drugs have been shown to be advantageous for women undergoing assisted conception. Using powerful Doppler imaging, it is now possible to identify perifollicular perfusion and hence the accurate selection of oocyte with good intracytoplasmic sperm injection (ICSI) outcome. Objective: The current study aimed to investigate the effects of aspirin and vaginal sildenafil citrate on improvement of the perifollicular blood flow, EG-VEGF and conception in females following ICSI cycles. Subjects and methods: Ninety infertile women were participated in ICSI cycles. Full investigation was made for participating women. Ovarian stimulation protocol was performed. Doppler ultrasonography was used to evaluate the perifollicular blood flow. Serum and follicular fluid EG-VEGF were measured. data analyzed using SSPS program. Results: Total oocytes count was significantly higher in aspirin group in comparison with sildenafil and control group. No significant difference in mean serum and follicular fluid EG-VEGF. Also, no significant difference in the proportions of PFBF and endometrial vascular zones. With respect to endometrial vascular zones, there was significant variation in favor of sildenafil and aspirin groups. Positive pregnancy test was reported in 40.0% of women in aspirin group, in (33.3 %) of women in sildenafil group and in (20.0 %) of women in placebo group, the difference was insignificant. Conclusion: Aspirin treatment resulted in higher number of total retrieved oocytes, aspirin and sildenafil did not improve endometrial thickness, but they resulted in an improvement of sub endometrial vascularity, however, biochemical pregnancy test was not affected by either pharmacological agent.

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Power Doppler ultrasound assessment of ovarian perifollicular blood flow in women with polycystic ovaries and normal ovaries during in vitro fertilization treatment

Cited by 14 publications

References 42 publications

The interovarian variation in three-dimensional ultrasound markers of ovarian reserve in women undergoing baseline investigation for subfertility

The interovarian variation in three-dimensional ultrasound markers of ovarian reserve in women undergoing baseline investigation for subfertility

The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome

Effectiveness of Low Dose Aspirin or Vaginal Sildenafil on Perifollicular Blood Flow Using Doppler ultrasound and EG-VEGF and their Impacts on ICSI Cycle Outcome

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