Power Doppler Ultrasonography is an Important Technique in Rheumatoid Arthritis, Ankylosing Spondylitis and Osteoarthritis Arthritis among Egyptians

Algergawy, Shereen; Ismail, Yasser

doi:10.1055/s-0035-1549912

Cited by 1 publication

(2 citation statements)

References 27 publications

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“…However, we did not establish a significant correlation between serum levels of VEGF and the Erosion score. US, an imaging technique with several advantages that make it almost indispensable in current daily practice, has a well-established role not only for diagnostic purposes but also to accurately evaluate the degree of vascularization in certain areas of interest, using PDUS [ 21 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. Both grayscale ultrasound (GSUS) and PDUS are useful in identifying patients with clinical remission who still display US subclinical inflammation and others with no sign of US active synovitis, and for establishing an evaluation algorithm that integrates several outcome measures.…”

Section: Discussionmentioning

confidence: 99%

“…In 2017, Algergawy et al reported a statistically significant correlation between VEGF synovial level and synovial thickness and/or effusion. They also noted a directly proportional relationship between higher synovial levels of VEGF and PDUS findings, results consequent to endothelial proliferation and synovial neoangiogenesis, mediated throughout VEGF [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

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MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients

Boldeanu,

Cristea

et al. 2023

Diagnostics

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Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us with a more accurate view of the evolution, prognosis, and future quality of life for these patients. Our aim was to analyze the presence and clinical use of matrix metalloproteinase-13 (MMP-13), along with vascular endothelial growth factor (VEGF) and well-known cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) for patients with RA. We also wanted to identify the possible correlations between MMP-13 and these serological markers, as well as their relationship with disease activity indices, quality of life, and ultrasonographic evaluation. For this purpose, we analyzed serum samples of 34 RA patients and 12 controls. In order to assess serum concentrations for MMP-13, VEGF, TNF-α, and IL-6, we used the enzyme-linked immunosorbent assay (ELISA) technique. Our results concluded that higher levels of MMP-13, VEGF, TNF-α, and IL-6 were present in the serum of RA patients compared to controls, with statistical significance. We furthermore identified moderately positive correlations between VEGF, MMP-13, and disease activity indices, as well as with the ultrasound findings. We also observed that VEGF had the best accuracy (97.80%), for differentiating patients with moderate disease activity. According to the data obtained in our study, that although MMP-13, TNF-α and C-reactive protein (CRP) have the same sensitivity (55.56%), MMP-13 has a better specificity (86.67%) in the diagnosis of patients with DAS28(4v) CRP values corresponding to moderate disease activity. Thus, MMP-13 can be used as a biomarker that can differentiate patients with moderate or low disease activity. VEGF and MMP-13 can be used as additional parameters, along with TNF-α and IL-6, that can provide the clinician a better picture of the inflammatory process, disease activity, and structural damage in patients with RA. Our data can certainly constitute a start point for future research and extended studies with multicenter involvement, to support the selection of individualized and accurate therapeutic management strategies for our patients.

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