Power Analysis for Human Melatonin Suppression Experiments
Manuel Spitschan,
Parisa Vidafar,
Sean W. Cain
et al.
Abstract:In humans, the nocturnal secretion of melatonin by the pineal gland is suppressed by ocular exposure to light. In the laboratory, melatonin suppression is a biomarker for this neuroendocrine pathway. Recent work has found that individuals differ substantially in their melatonin-suppressive response to light, with the most sensitive individuals being up to 60 times more sensitive than the least sensitive individuals. Planning experiments with melatonin suppression as an outcome needs to incorporate these indivi… Show more
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