Powder Flow Studies III

Gold, Gerald; Duvall, Ronald N.; Palermo, Blaze T.; Slater, James G.

doi:10.1002/jps.2600570429

Cited by 40 publications

(3 citation statements)

References 11 publications

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“…This behavior came as a surprise, since increased magnesium stearate content of powders was linked with improved flow characteristics (24)(25)(26) by reducing adhesion and capillary forces (27,28). Lubrication, however, is not only dependent on the lubricant content, but also on the blending time and mixing intensity.…”

Section: Evaluation Of Variables Affecting Powder Mixture Propertiesmentioning

confidence: 99%

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

Szabó

Székely-Szentmiklósi²,

Deák

et al. 2016

Acta Pharmaceutica

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Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental designTo evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. Because of the low active pharmaceutical ingredient content, it was hypothesized that both powder and tablet properties could be determined only by the characteristics of excipients. In order to test this assumption, both experimental designs were done with placebo mixtures. The optimized formulation was then evaluated both with and without APIs. Results indicated that filler and lubricant percentage, along with compression force, were the most important variables during the formulation study. The optimized formulation showed similar characteristics in both cases for all responses, except for angle of repose and friability where only minor differences were observed. The combination of the applied approaches (using placebo composition and fractional experimental design) proved to be efficient, cost effective and time saving.Keywords: design of experiments, optimization, factorial design, placebo formulation Proper management of hypertension, one of the leading causes of cardiovascular disease, is of the utmost importance. It has been established that lowering of blood pressure can effectively reduce the risk of cardiovascular events and stroke, but finding the most appropriate therapy is often difficult (1). Combinational therapies employing an angiotensin-converting enzyme inhibitor (ACEi) and indapamide (IND) offer the advantage of using two highly effective agents, increasing both clinical efficiency and patient compliance (2-4). Low dose combinations of ACEis and diuretics have shown greater reduction in blood pressure and higher success rates in managing hypertension than either of the treatments alone (4-6). The most popular ACEis present in these combinations include perin- Szabo et al.: Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design, Acta Pharm. 66 (2016) 191-206.

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Section: Evaluation Of Variables Affecting Powder Mixture Propertiesmentioning

confidence: 99%

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

Szabó

Székely-Szentmiklósi²,

Deák

et al. 2016

Acta Pharmaceutica

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“…If their concentrations are taken beyond a certain limit, a drag action may occur and this will reduce the rate of flow. They are classified into hydrophobic such as‐talc, silicon dioxide, calcium phosphate and metallic stearates; and hydrophilic such as lactose and sorbitol …”

Section: Introductionmentioning

confidence: 99%

The Glidant Properties of Cyperus esculentus, L (Tigernut) Starch in Metronidazole Tablet Formulation

2017

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The glidant property of starch obtained from the tubers of Cyperus esculentus, L is evaluated in comparison with purified talc and aerosil in metronidazole tablet formulation. C. esculentus starch is characterized using material, proximate, FTIR, and rheological properties in comparison with corn starch BP. Metronidazole granules are prepared using wet granulation method, the granules are mixed with glidants (1–4% w/w) for 5 min and the flow characteristics determined. Tablets are compressed with a single punch machine at predetermined loads and evaluated using mechanical and release properties. The results shows that the proximate and material properties of C. esculentus are significantly different (p < 0.05) from corn starch in fat content, particle size, carr's index, water absorption capacity, and solubility. The FTIR revealed functional groups similar to that of corn starch while rheological profiles revealed that the starch will be able to withstand heat during tablet compression. The granules after the addition of glidants shows excellent flow according to Hausner ratio and Carr's index values. C. esculentus starch improved the flowabilty of granules used for the tablet formulations thus enhancing production process and outcome. The tablets with the highest balance of mechanical and release properties were those containing 2% w/w of C. esculentus starch and the difference is significantly higher in comparison to tablets containing other glidants. The results shows that C. esculentus starch could be suitable as a glidant in pharmaceutical tablet formulations.

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“…Importantly, analysis in the solid phase retains physical information in addition to chemical information. The physical information content includes identity and purity of crystal form , and information relating to the size distribution of sample particles. , Crystal form is a crucial pharmaceutical property affecting solid-state stability as well as potentially determining the efficacy of the dosage form. , The particle size distribution affects the handling properties of powders, such as the flowability through formulation equipment, and the dissolution rate, which may in turn affect tablet weight variation and bioavailability of an active, respectively. Along with retention of physical information are the advantages of speed and simplicity of the analysis.…”

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confidence: 99%

Measurement of Residual Isopropyl Alcohol in Loracarbef by Near-Infrared Reflectance Spectroscopy

1999

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A near-infrared reflectance spectroscopic (NIRS) method was developed and validated for the measurement of isopropyl alcohol (IPA) in loracarbef. A partial leastsquares calibration was established for a set of 30 samples by correlation to the gas chromatographic reference method. The NIRS method was validated for selectivity, accuracy, precision, and robustness. The intermediate precision of the method was estimated to be 0.17%, comparing favorably to the precision of the GC reference method. During validation of the robustness of the method, sample analysis technique was found to be responsible for a statistically significant analyst bias. The bias was eliminated by standardization of the technique. Additionally, samples were found to lose IPA when opened to the laboratory atmosphere.

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Powder Flow Studies III

Cited by 40 publications

References 11 publications

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

The Glidant Properties of Cyperus esculentus, L (Tigernut) Starch in Metronidazole Tablet Formulation

Measurement of Residual Isopropyl Alcohol in Loracarbef by Near-Infrared Reflectance Spectroscopy

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