Povidone iodine plus neosporin in superficial burns — a continuing study

Sinha, Rajeev; Agarwal, Rahul; Agarwal, Mukesh

doi:10.1016/s0305-4179(97)00069-7

Cited by 33 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, topical antibiotics, like mupirocin (6) and Neosporin (7), are ineffective when resistant bacteria colonize the wound (8,9). Furthermore, these antimicrobials are not effective because bacteria in biofilms can be up to 1,000-fold less sensitive to antibiotics than their planktonic counterparts (10)(11)(12).…”

mentioning

confidence: 99%

LL-37-Derived Peptides Eradicate Multidrug-Resistant Staphylococcus aureus from Thermally Wounded Human Skin Equivalents

Haisma

Breij

Chan

et al. 2014

Antimicrob Agents Chemother

120

View full text Add to dashboard Cite

Burn wound infections are often difficult to treat due to the presence of multidrug-resistant bacterial strains and biofilms. Currently, mupirocin is used to eradicate methicillin-resistant Staphylococcus aureus (MRSA) from colonized persons; however, mupirocin resistance is also emerging. Since we consider antimicrobial peptides to be promising candidates for the development of novel anti-infective agents, we studied the antibacterial activities of a set of synthetic peptides against different strains of S. aureus, including mupirocin-resistant MRSA strains. The peptides were derived from P60.4Ac, a peptide based on the human cathelicidin LL-37. The results showed that peptide 10 (P10) was the only peptide more efficient than P60.4Ac, which is better than LL-37, in killing MRSA strain LUH14616. All three peptides displayed good antibiofilm activities. However, both P10 and P60.4Ac were more efficient than LL-37 in eliminating biofilm-associated bacteria. No toxic effects of these three peptides on human epidermal models were detected, as observed morphologically and by staining for mitochondrial activity. In addition, P60.4Ac and P10, but not LL-37, eradicated MRSA LUH14616 and the mupirocin-resistant MRSA strain LUH15051 from thermally wounded human skin equivalents (HSE). Interestingly, P60.4Ac and P10, but not mupirocin, eradicated LUH15051 from the HSEs. None of the peptides affected the excretion of interleukin 8 (IL-8) by thermally wounded HSEs upon MRSA exposure. In conclusion, the synthetic peptides P60.4Ac and P10 appear to be attractive candidates for the development of novel local therapies to treat patients with burn wounds infected with multidrug-resistant bacteria.

show abstract

mentioning

confidence: 99%

LL-37-Derived Peptides Eradicate Multidrug-Resistant Staphylococcus aureus from Thermally Wounded Human Skin Equivalents

Haisma

Breij

Chan

et al. 2014

Antimicrob Agents Chemother

120

View full text Add to dashboard Cite

show abstract

“…Povidone iodine solution may be toxic to tissues in higher concentration [28] however numerous randomised controlled trial studies on chronic wounds including burn wound, concluded that quicker wound healing and a reduction of bacteria with povidone iodine-impregnated gauze dressing treated wounds. [29][30][31] In our study in both group, wounds were daily washed with 5% povidone iodine solution and conventional group dressing was done with 5% povidone iodine soaked gauze after squeezing it to make it good absorbent of wound soakage by capillary action.…”

Section: Discussionmentioning

confidence: 99%

Effects of limited access dressing in chronic wounds: A biochemical and histological study

Honnegowda

Kumar

Udupa

et al. 2015

Indian J Plast Surg

View full text Add to dashboard Cite

Background:Negative pressure wound therapy has emerged as an attractive treatment modality for the management and healing of chronic ulcers. Though numerous clinical studies are available, there is a lack of biochemical and histological studies evaluating the healing of chronic wounds.Materials and Methods:In the present study, a total 60 patients were divided into two groups: Limited access dressing (LAD) group (n = 30) and conventional dressing group (n = 30). Various biochemical parameters such as hydroxyproline, total protein and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) and oxidative biomarker malondialdhyde (MDA) are measured in the granulation tissue. Histologically amount of inflammatory infiltrate, angiogenesis, and collagen deposition are studied to assess wound healing.Results:Patients treated with LAD have shown significant increase in the mean (±standard deviation) hydroxyproline (77.3 ± 30.1 vs. 32.3 ± 16.18; P = 0.026), total protein (13.89 ± 9.0 vs. 8.9 ± 4.59; P = 0.004), GSH (7.4 ± 1.91 vs. 5.1 ± 1.28; P = 0.039), GPx (122.3 ± 59.3 vs. 88.7 ± 34.11; P = 0.030), CAT (1.80 ± 1.14 vs. 0.9 ± 0.71; P = 0.002) and decrease in MDA (13.4 ± 5.5 vs. 8.6 ± 3.8; P = 0.004). Histological study showed comparatively fewer inflammatory cells, increased and well organised collagen bundles, and more angiogenesis in the LAD group when compared with that with conventional dressing after 10 days of treatment.Conclusion:In the present study, we have found beneficial effect of newer intermittent negative pressure therapy in combination with moist environment (LAD) on chronic wound healing by increasing collagen deposition and angiogenesis; and reducing oxidative stress and inflammatory infiltrate.

show abstract

“…Similarly, healing times were also better with PVP + N, with a maximum number of patients having healed within 15 days. However, the mortality rates were not much different between the two groups [36]. …”

Section: Topical Antibioticsmentioning

confidence: 99%

Topical Antimicrobials for Burn Wound Infections

Dai

Huang²,

Sharma³

et al. 2010

PRI

222

149

View full text Add to dashboard Cite

Throughout most of history, serious burns occupying a large percentage of body surface area were an almost certain death sentence because of subsequent infection. A number of factors such as disruption of the skin barrier, ready availability of bacterial nutrients in the burn milieu, destruction of the vascular supply to the burned skin, and systemic disturbances lead to immunosuppression combined together to make burns particularly susceptible to infection. In the 20th century the introduction of antibiotic and antifungal drugs, the use of topical antimicrobials that could be applied to burns, and widespread adoption of early excision and grafting all helped to dramatically increase survival. However the relentless increase in microbial resistance to antibiotics and other antimicrobials has led to a renewed search for alternative approaches to prevent and combat burn infections. This review will cover patented strategies that have been issued or filed with regard to new topical agents, preparations, and methods of combating burn infections. Animal models that are used in preclinical studies are discussed. Various silver preparations (nanocrystalline and slow release) are the mainstay of many approaches but antimicrobial peptides, topical photodynamic therapy, chitosan preparations, new iodine delivery formulations, phage therapy and natural products such as honey and essential oils have all been tested. This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multi-drug resistance.

show abstract

Povidone iodine plus neosporin in superficial burns — a continuing study

Cited by 33 publications

References 7 publications

LL-37-Derived Peptides Eradicate Multidrug-Resistant Staphylococcus aureus from Thermally Wounded Human Skin Equivalents

LL-37-Derived Peptides Eradicate Multidrug-Resistant Staphylococcus aureus from Thermally Wounded Human Skin Equivalents

Effects of limited access dressing in chronic wounds: A biochemical and histological study

Topical Antimicrobials for Burn Wound Infections

Contact Info

Product

Resources

About