Povidone iodine in the treatment of adenoviral conjunctivitis in infants

Tunay, Zühal Özen; Özdemir, Özdemir; Petriçli, İkbal Seza

doi:10.3109/15569527.2014.888077

Cited by 28 publications

(6 citation statements)

References 14 publications

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“…A review of the references and citations did not yield any additional articles. Thirty-two studies were included in the analysis; of these, 11 had a methodological quality level of 1 or 2 (details of the included studies appear in eTable 1 in the Supplement). These studies included 24 case series, 5 randomized clinical trials, 1 nonrandomized comparative trial, and 2 cohort studies.…”

Section: Resultsmentioning

confidence: 99%

Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection?

Johnson

Liu

Simel

2022

JAMA

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IMPORTANCE Acute infectious conjunctivitis is characterized by ocular redness and discharge, and is a common clinical entity. Evidence-based tools to aid the clinical diagnosis of viral vs bacterial conjunctivitis are lacking and may contribute to overprescribing of topical antibiotics.OBJECTIVE To determine the relative prevalence of viral vs bacterial conjunctivitis in adults and children, and to determine which symptoms or signs are suggestive of a viral vs bacterial etiology.DATA SOURCES A MEDLINE search (January 1946-March 2022) yielded 1891 articles. Included articles were rated using a quality score based on a modified Rational Clinical Examination grading system. Methodological quality levels 1 through 4 required a microbiological reference standard for diagnosis, whereas quality level 5 (the lowest quality) used a clinical reference standard for diagnosis.STUDY SELECTION Consecutive series of patients presenting with acute infectious conjunctivitis and case series of viral or bacterial conjunctivitis alone. Thirty-two studies were included in a meta-analysis to determine prevalence and diagnostic accuracy measures; 27 used a microbiological reference standard for diagnosis and 5 used a clinical reference standard for diagnosis. RESULTSIn studies involving children (5 studies; 881 patients; mean age, 4.7 years [age range, 1 month-18 years]), the prevalence of bacterial conjunctivitis was higher than viral conjunctivitis (71% vs 16%, respectively, P = .01). In the only study of adults (n = 207 patients; mean age, 25.7 years), the prevalence of viral conjunctivitis was higher than bacterial conjunctivitis (78% vs 16%, respectively, P < .001). For the primary analysis of level 1 (n = 6) and level 2 (n = 5) studies (1725 patients total), the clinical findings that best distinguished a viral etiology for conjunctivitis from a bacterial etiology included pharyngitis (sensitivity range, 0.55-0.58; specificity range, 0.89-0.94; positive likelihood ratio [LR] range, 5.4-9.9), preauricular lymphadenopathy (sensitivity range, 0.17-0.31; specificity range, 0.93-0.94; positive LR range, 2.5-5.6), and contact with another person with red eye (

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Section: Resultsmentioning

confidence: 99%

Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection?

Johnson

Liu

Simel

2022

JAMA

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“…In healthy newborns, 1.25% PI was as effective as 2.5% in reducing the number of colony-forming units 40 and 2.5% PI decreased adenoviral conjunctivitis. 41 Carrim et al demonstrated that a 3 min treatment with PI decreased the number of positive cultures in patients 42 and a 10% treatment reduced the number of colony-forming units in patients undergoing cataract surgery. 43 The optimum time and concentration of PI to prevent infections is unknown, however, 5% PI decreases bacterial load significantly more than 1% PI in vivo, while in vitro studies indicate the opposite is true with lower PI concentrations appearing to decrease bacterial load more than higher concentrations.…”

Section: Discussionmentioning

confidence: 99%

Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture

et al. 2020

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ObjectiveTo determine the effect of povidone iodine (PI), an antiseptic commonly used prior to ocular surgery, on viability of mixed populations of conjunctival stratified squamous and goblet cells, purified conjunctival goblet cells and purified conjunctival stromal fibroblasts in primary culture.Methods and analysisMixed population of epithelial cells (stratified squamous and goblet cells), goblet cells and fibroblasts were grown in culture from pieces of human conjunctiva using either supplemented DMEM/F12 or RPMI. Cell type was evaluated by immunofluorescence microscopy. Cells were treated for 5 min with phosphate-buffered saline (PBS); 0.25%, 2.5%, 5% or 10% PI in PBS; or a positive control of 30% H2O2. Cell viability was determined using Alamar Blue fluorescence and a live/dead kit using calcein/AM and ethidium homodimer-1 (EH-1).ResultsMixed populations of epithelial cells, goblet cells and fibroblasts were characterised by immunofluorescence microscopy. As determined with Alamar Blue fluorescence, all concentrations of PI significantly decreased the number of cells from all three preparation types compared with PBS. As determined by calcein/EH-1 viability test, mixed populations of cells and fibroblasts were less sensitive to PI treatment than goblet cells. All concentrations of PI, except for 0.25% used with goblet cells, substantially increased the number of dead cells for all cell populations. The H2O2 control also significantly decreased the number and viability of all three types of cells in both tests.ConclusionWe conclude that PI, which is commonly used prior to ocular surgeries, is detrimental to human conjunctival stratified squamous cells, goblet cells and fibroblasts in culture.

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“…Also some authors found povidone iodine 2.5% as an effective treatment in AVC [19]. We used the same treatment methodology during the course of AVC.…”

Section: Discussionmentioning

confidence: 99%

Treatment for Retinopathy of Prematurity in an Infant with Adenoviral Conjunctivitis

Günay

Çelik

Con

2015

Case Reports in Pediatrics

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Retinopathy of prematurity (ROP) has been a major problematic disorder during childhood. Laser photocoagulation (LPC) has been proven to be effective in most of the ROP cases. Adenoviral conjunctivitis (AVC) is responsible for epidemics among adult and pediatric population. It has also been reported to be a cause of outbreaks in neonatal intensive care units (NICU) several times. We herein demonstrate a case with AVC who underwent LPC for ROP. And we discuss the treatment methodology in such cases.

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Povidone iodine in the treatment of adenoviral conjunctivitis in infants

Abstract: Conjunctival irrigation with 2.5% povidone iodine is effective in the treatment of adenoviral conjunctivitis in infants.

Cited by 28 publications

References 14 publications

Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection?

Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection?

Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture

Treatment for Retinopathy of Prematurity in an Infant with Adenoviral Conjunctivitis

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