Povidone iodine gargle and mouthwash

Hassandarvish, Pouya; Tiong, Vunjia; Sazaly, A B; Mohamed, Nurul Azmawati; Arumugam, Harsha; Ananthanarayanan, Abhishek; Qasuri, Murtaza; Hadjiat, Yacine

doi:10.1038/s41415-020-1794-1

Cited by 20 publications

(29 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gargle and mouth rinse with solutions containing PVP-I at 1% achieved a virucidal activity higher than 99.99%, which corresponds to a reduction of virus load greater than 4 log 10 , after 30 s of contact ( Anderson et al 2020 ). These results are in accordance with those of Hassandarvish et al (2020) , who concluded that PVP-I 1% achieved a more than 5 log 10 reduction in the virus titers after 15, 30, and 60 s of treatment. Applying 0.5% PVP-I for 15 s reduces the SARS-CoV-2 load by 4 log 10 , whereas application for 30 or 60 s reduces the load by more than 5 log 10 ( Hassandarvish et al 2020 ).…”

Section: Mouth Rinse Reagents With In Vitro or In Vivo Anti–sars-cov-supporting

confidence: 93%

Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

The oral cavity, an essential part of the upper aerodigestive tract, is believed to play an important role in the pathogenicity and transmission of SARS-CoV-2. The identification of targeted antiviral mouth rinses to reduce salivary viral load would contribute to reducing the COVID-19 pandemic. While awaiting the results of significant clinical studies, which to date do not exist, the commercial availability of mouth rinses leads us to search among them for reagents that would have specific antiviral properties with respect to SARS-CoV-2. The challenges facing this target were examined for 7 reagents found in commercially available mouth rinses and listed on the ClinicalTrials.gov website: povidone-iodine, chlorhexidine, hydrogen peroxide, cyclodextrin, Citrox, cetylpyridinium chloride, and essential oils. Because SARS-CoV-2 is an enveloped virus, many reagents target the outer lipid membrane. Moreover, some of them can act on the capsid by denaturing proteins. Until now, there has been no scientific evidence to recommend mouth rinses with an anti–SARS-CoV-2 effect to control the viral load in the oral cavity. This critical review indicates that current knowledge of these reagents would likely improve trends in salivary viral load status. This finding is a strong sign to encourage clinical research for which quality protocols are already available in the literature.

show abstract

Section: Mouth Rinse Reagents With In Vitro or In Vivo Anti–sars-cov-supporting

confidence: 93%

Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

show abstract

“…We previously reported these findings in abbreviated form. 27 In summary, the PVP-I product was tested at 15, 30 and 60 seconds and demonstrated ≥4 log10 reduction of SARS-CoV-2 titres (corresponding to a ≥99.99% kill rate) for all contact times, under both clean and dirty conditions. This meets the ECHA standards for disinfectant efficacy, indicating its potent and rapid virucidal activity.…”

Section: Cytotoxicitymentioning

confidence: 91%

In vitro virucidal activity of povidone iodine gargle and mouthwash against SARS-CoV-2: implications for dental practice

et al. 2020

View full text Add to dashboard Cite

Introduction Virus particles in respiratory droplets and aerosols generated during medical/dental procedures are a potential source of SARS-CoV-2 cross infection. In the dental setting, oral decontamination could be an important adjunct to personal protective equipment and is recommended by a number of national COVID-19 guidance documents for dental settings. Aim To assess the in vitro virucidal activity of an oral povidone iodine (PVP-I) product against SARS-CoV-2. Material and methods BETADINE gargle and mouthwash (1% PVP-I) was tested against SARS-CoV-2 virus under both clean and dirty conditions using a suspension assay based on EN14476 methodology. Virucidal activity of the product, undiluted and at 1:2 dilution, was tested at contact times of 15, 30 and 60 seconds. Viral titres were calculated using the Spearman-Kärber method and reported as median tissue culture infectious dose (TCID 50 /ml). Results The undiluted product achieved >5 log10 reduction in viral titres compared to the control at 15, 30 and 60 seconds under both clean and dirty conditions. At a twofold dilution (0.5% PVP-I), the test product demonstrated >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in both clean and dirty conditions. Conclusion PVP-I gargle and mouthwash product, undiluted and at 1:2 dilution, demonstrated potent and rapid virucidal activity (≥4 log10 reduction of viral titre) in 15 seconds against SARS-CoV-2 in vitro. The PVP-I gargle and mouthwash product is widely available and could be readily integrated into infection control measures during dental treatment including pre-procedural oral decontamination.

show abstract

“…A one-off participation fee of £250 will be offered to each contractor and in addition, a flat fee of £8.27 will be paid per immunisation. 3 NHS Education for Scotland is developing learning resources to support delivery of the flu vaccination programme. This is in line with the guidance from the General Dental Council that dental professionals must be trained and competent for all skills and treatment that they undertake.…”

Section: K S Fakhruddin Sharjah Uae; H C Ngo Perth Australia;mentioning

confidence: 99%

“…This is in line with the guidance from the General Dental Council that dental professionals must be trained and competent for all skills and treatment that they undertake. 3 Indemnity cover for dentists will be provided by the Scottish Government. Other members of the dental team will not be allowed to deliver vaccinations.…”

Section: K S Fakhruddin Sharjah Uae; H C Ngo Perth Australia;mentioning

confidence: 99%

“…There is now ample data to indicate the viricidal potential of both silver and iodide containing formulations. 3,5,6 Hence, we wish to propose that, for children younger than six years of age, the swabbing of the procedure site with gauze soaked in povidone-iodine should be followed by application of SDF and KI. The latter, while potentiating the antimicrobial effect, can also be an extremely effective dentine desensitiser.…”

mentioning

confidence: 99%

See 1 more Smart Citation