Poultry Consumption and Arsenic Exposure in the U.S. Population

Nigra, Anne E.; Nachman, Keeve E.; Grau-Pérez, María; Navas‐Acien, Ana

doi:10.1289/ehp331

Cited by 5 publications

(5 citation statements)

References 35 publications

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“… 35 Using data from 3,329 participants aged ≥6 years in NHANES 2003–2010 with undetectable arsenobetaine concentrations, poultry intake was positively associated with concentrations of total arsenic and DMA in urine (GM ratios were 1.12 [95% CI: 1.04, 1.22] for total arsenic and 1.13 [95% CI: 1.06, 1.20] for DMA comparing the highest quartile of poultry consumption to non-consumers). 62 …”

Section: Discussionmentioning

confidence: 99%

Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA)

Jones

Téllez-Plaza

Vaidya

et al. 2018

J Expo Sci Environ Epidemiol

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Differences in residential location as well as race/ethnicity and dietary habits may result in differences in inorganic arsenic (iAs) exposure. We investigated the association of exposure to iAs with race/ethnicity, geography and dietary intake in a random sample of 310 White, Black, Hispanic and Chinese adults in the Multi-Ethnic Study of Atherosclerosis from 6 US cities with inorganic and methylated arsenic (ΣAs) measured in urine. Dietary intake was assessed by food frequency questionnaire. Chinese and Hispanic race/ethnicity was associated with 82% (95% CI: 46%, 126%) and 37% (95% CI: 10%, 70%) higher urine arsenic concentrations, respectively, compared to White participants. No differences were observed for Black participants compared to Whites. Urine arsenic concentrations were higher for participants in Los Angeles, Chicago and New York compared to other sites. Participants that ate rice ≥2 times/week had 31% higher urine arsenic compared to those that rarely/never consumed rice. Participants that drank wine ≥2 times/week had 23% higher urine arsenic compared to rare/never wine drinkers. Intake of poultry or non-rice grains was not associated with urinary arsenic concentrations. At the low-moderate levels typical of the US population, exposure to iAs differed by race/ethnicity, geographic location and frequency of rice and wine intake.

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Section: Discussionmentioning

confidence: 99%

Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA)

Jones

Téllez-Plaza

Vaidya

et al. 2018

J Expo Sci Environ Epidemiol

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“…Roxarsone was first synthesized in 1923 (British patent GB 226255 19230718) and has been used commercially since 1944 () for prevention of coccidiosis in chickens and other farm animals . In 2010 nearly 90% of all broiler chickens in the U.S. were estimated to be treated with roxarsone . Roxarsone is excreted from chickens as a mixture of unaltered and partially metabolized species. , The manure is used as fertilizer for commercial crops or disposed of in landfills .…”

Section: Discussionmentioning

confidence: 99%

“…In 2011 the U.S. manufacturer, Alpharma, discontinued sales of roxarsone. Even though roxarsone is no longer used in the United States, it is still produced and used in other countries. ,, When the chicken litter is used as a fertilizer or moved into landfills, roxarsone and its metabolites are broken down to inorganic arsenic, where the resulting inorganic arsenate and arsenite can be taken up by crop plants or, through agricultural runoff, enter the water supply of local communities. , The entrance of breakdown products of roxarsone and other aromatic arsenicals represents a major anthropogenic source of arsenic exposure in the U.S. and elsewhere in the world …”

Section: Discussionmentioning

confidence: 99%

Biochemical Characterization of ArsI: A Novel C–As Lyase for Degradation of Environmental Organoarsenicals

Pawitwar

Nadar

Kandegedara

et al. 2017

Environ. Sci. Technol.

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Organoarsenicals such as the methylarsenical methylarsenate (MAs(V)) and aromatic arsenicals including roxarsone (4-hydroxy-3-nitro-benzenearsenate or Rox(V)) have been extensively used as an herbicide and growth enhancers in animal husbandry, respectively. They undergo environmental degradation to more toxic inorganic arsenite (As(III)) that contaminates crops and drinking water. We previously identified a bacterial gene (arsI) responsible for aerobic demethylation of methylarsenite (MAs(III)). The gene product, ArsI, is an Fe(II)-dependent extradiol dioxygenase that cleaves the carbon–arsenic (C–As) bond in MAs(III) and in trivalent aromatic arsenicals. The objective of this study was to elucidate the ArsI mechanism. Using isothermal titration calorimetry, we determined the dissociation constants and ligand-to-protein stoichiometry of ArsI for Fe(II), MAs(III), and aromatic phenylarsenite. Using a combination of methods including chemical modification, site-directed mutagenesis, and fluorescent spectroscopy, we demonstrated that amino acid residues predicted to participate in Fe(II)-binding (His5–His62–Glu115) and substrate binding (Cys96–Cys97) are involved in catalysis. Finally, the products of Rox(III) degradation were identified as As(III) and 2-nitrohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxygen into the carbon and the other to the arsenic to catalyze cleavage of the C–As bond. These results augment our understanding of the mechanism of this novel C–As lyase.

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“…Arsenic is a major global environmental contaminant, and legislation is in place in many countries to limit human exposure to arsenic from water and food. The major arsenic species of concern is inorganic arsenic (iAs), a known toxic substance, , that is present in drinking water and some foods. , The organic forms of arsenic such as arsenobetaine and arsenosugars, which can occur at high concentrations in seafoods, have been perceived as nontoxic on the basis of results of toxicity testing of just a few organoarsenicals. , Those toxicity studies, however, were all performed with water-soluble organoarsenic compounds.…”

Section: Introductionmentioning

confidence: 99%

Arsenolipids Detected in the Milk of Nursing Mothers

Stiboller

Raber

Lenters

et al. 2017

Environ. Sci. Technol. Lett.

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Arsenic-containing lipids (arsenolipids), common constituents of fish, are currently being studied with regard to human health because of recent research that showed that some of the compounds are highly toxic to human cells and that they have the potential to cross the blood−brain barrier. As part of a study of the role of early exposure to environmental toxicants, we determined the arsenic content of milk from nursing mothers. Although the original intention of the study was to focus on inorganic arsenic, we discovered in an initial testing of 10 samples that a significant portion of the arsenic in the milk was lipid-soluble. We then investigated in detail this lipid-soluble arsenic in five of the samples by purifying the major compounds and using high-performance liquid chromatography coupled to both elemental and molecular mass spectrometry to identify them as arsenic hydrocarbons and arsenic fatty acids. This study is the first to report the presence of arsenolipids in human milk. The concentrations of arsenolipids in the milk were low (combined total of approximately 0.5 μg of As/kg) compared to the current recommended maximum for arsenic in water (10 μg/L), but of potential concern when one considers the possibility of the lipids crossing the blood−brain barrier and the critical stage of brain development in the newborn child.

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Poultry Consumption and Arsenic Exposure in the U.S. Population

Cited by 5 publications

References 35 publications

Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA)

Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA)

Biochemical Characterization of ArsI: A Novel C–As Lyase for Degradation of Environmental Organoarsenicals

Arsenolipids Detected in the Milk of Nursing Mothers

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