Pouchitis, Similar to Active Ulcerative Colitis, Is Associated with Impaired Butyrate Oxidation by Intestinal Mucosa

Preter, Vicky De; Bulteel, Veerle; Suenaert, Peter; Geboes, Karen; Hertogh, Gert De; Luypaerts, Anja; Geboes, Karel; Verbeke, Kristin; Rutgeerts, Paul

doi:10.1002/ibd.20768

Cited by 35 publications

(21 citation statements)

References 32 publications

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“…The ileal pouch functions as a new reservoir to store stool and undergoes physiologic changes to become more “colon-like” within the first 4 months, including colonic epithelial function and a microbial composition similar to that residing in the colon (5, 6). Although the ileal tissue is initially normal, nearly half of the patients develop inflammation of the pouch (pouchitis), which exhibits histologic and endoscopic features similar to UC (7). The similarities between pouchitis and UC coupled with the predictable incidence of pouchitis enables prospective longitudinal investigations of UC etiology prior to inflammation.…”

Section: Introductionmentioning

confidence: 99%

Patient-Specific Bacteroides Genome Variants in Pouchitis

Vineis

Ringus

Morrison

et al. 2016

mBio

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A 2-year longitudinal microbiome study of 22 patients who underwent colectomy with an ileal pouch anal anastomosis detected significant increases in distinct populations of Bacteroides during 9 of 11 patient visits that coincided with inflammation (pouchitis). Oligotyping and metagenomic short-read annotation identified Bacteroides populations that occurred in early samples, bloomed during inflammation, and reappeared after antibiotic treatment. Targeted cultivation of Bacteroides isolates from the same individual at multiple time points and from several patients detected subtle genomic changes, including the identification of rapidly evolving genomic elements that differentiate isogenic strains of Bacteroides fragilis from the mucosa versus lumen. Each patient harbored Bacteroides spp. that are closely related to commonly occurring clinical isolates, including Bacteroides ovatus, B. thetaiotaomicron, B. vulgatus, and B. fragilis, which contained unique loci in different patients for synthesis of capsular polysaccharides. The presence of unique Bacteroides capsular polysaccharide loci within different hosts and between the lumen and mucosa may represent adaptations to stimulate, suppress, and evade host-specific immune responses at different microsites of the ileal pouch.

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Section: Introductionmentioning

confidence: 99%

Patient-Specific Bacteroides Genome Variants in Pouchitis

Vineis

Ringus

Morrison

et al. 2016

mBio

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“…In active pouchitis (like in active ulcerative colitis), butyrate oxidation is significantly decreased compared with that in the normal intestine [62]. SCFAs play an important role in the maintenance of colonic homeostasis, and it is logical to consider that they may contribute to the environment needed for healthy pouch mucosa, especially given its colon-like characteristics.…”

Section: Treatment Of Chronic Antibiotic-refractory Pouchitismentioning

confidence: 99%

Pouchitis

Liu

Song²,

Shen

2014

Current Opinion in Clinical Nutrition and Metabolic Care

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“…For example, in UC patients, decreased fecal concentrations of butyrate and propionate have been reported [44]. Impaired butyrate oxidation was also reported in patients with UC [48, 49]. …”

Section: Disease States Linked With Scfasmentioning

confidence: 99%

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity

Soldavini

Kaunitz

2013

Dig Dis Sci

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Background The lumen of the gastrointestinal tract contains many substances produced from the breakdown of foodstuffs, from salivary, esophageal, intestinal, hepatic, and pancreatic secretions, and from sloughed cells present in the gastrointestinal lumen. Although these substances were traditionally regarded as waste products, there is increasing realization that many can be biologically active, either as signalling compounds or as nutrients. For example, proteins are broken down into amino acids, which are then sensed by nutrient receptors. The gut microbiome, which is at highest abundance in the ileocecum, has powerful metabolic activity, digesting and breaking down unabsorbed carbohydrates, proteins, and other ingested nutrients into phenols, amines, volatile organic compounds, methane, carbon dioxide, hydrogen, and hydrogen sulfide into volatile fatty acids, also called short-chain fatty acids (SCFAs). Conclusion These latter substances are the topic of this review. In this review, we will briefly discuss recent advances in the understanding SCFA production, signalling, and absorption, followed by a detailed description and discussion of trials of SCFAs, probiotics, and prebiotics in the treatment of gastrointestinal disease, in particular ulcerative colitis (UC), pouchitis, short bowel syndrome, and obesity.

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Pouchitis, Similar to Active Ulcerative Colitis, Is Associated with Impaired Butyrate Oxidation by Intestinal Mucosa

Abstract: Active UC and pouchitis show the same inflammation-related metabolic defect. Our data suggest that the defect is a consequence of inflammation and that pouchitis is metabolically similar to active UC.

Cited by 35 publications

References 32 publications

Patient-Specific Bacteroides Genome Variants in Pouchitis

Patient-Specific Bacteroides Genome Variants in Pouchitis

Pouchitis

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity

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