Pouch drug delivery systems for dermal and transdermal administration

Zailer, Jana; Touítou, Elka

doi:10.1007/s13346-014-0204-0

Cited by 4 publications

(9 citation statements)

References 21 publications

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“…In our previous study on Weblike delivery systems, 31 P-NMR spectra suggested a reverse micellar organization of phospholipid in high ethanolic solutions [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

“…A weblike carrier comprises phospholipid, ethanol, a film-forming polymer and optionally water. Additives such as glycols, Vit E and ethyl acetate can also be part of the Weblike carrier [ 17 , 18 ]. The Weblike carrier that we call Cannaweb contains added HSO to enhance the dermal and transdermal delivery of lipophilic molecules such as cannabinoids [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…Klucel ® HF was dispersed in the solution while mixing at the same speed. The system was left to repose and then remixed [ 17 , 18 ]. For Cannaweb carrier preparation, phospholipid was dissolved in ethanol, then HSO was added.…”

Section: Methodsmentioning

confidence: 99%

“…When applied to the skin, these formulations, containing phospholipid reverse micelles, dry, rapidly forming associates of phospholipid reservoirs organized in a web-like (or Pouches) structured matrix film. The work proved the concept behind using reverse phospholipid micelles in a matrix film-forming delivery carrier [ 17 ].…”

Section: Introductionmentioning

confidence: 98%

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Film Forming Systems for Delivery of Active Molecules into and across the Skin

2023

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We have investigated delivery systems that can form a structured matrix film on the skin after their application. In a previous work, we have shown that Weblike film forming systems (also called Pouches Drug Delivery Systems, PDDS) enable enhanced skin delivery of the incorporated molecules. These delivery systems are composed of one or more phospholipids, a short-chain alcohol, a polymer and optionally water. In this work, we continue the investigation and characterization of Weblike carriers focusing on some factors affecting the delivery properties such as components concentration and mode of application on the skin. Upon non-occluded application on the skin, the systems dry rapidly, forming a web-like structured film. Lidocaine, Ibuprofen, FITC and Cannabidiol are molecules with various physico-chemical properties that were incorporated in the carrier. The systems were tested in a number of in vitro and in vivo experiments. Results of the in vitro permeation of Ibuprofen through porcine skin indicated two-fold delivery through the skin of Ibuprofen when applied from our Weblike system in comparison with a nanovesicular carrier, the ethosome. We also have investigated weblike systems containing hemp seed oil (HSO). This addition enhanced the film’s ability to deliver lipophilic molecules to the deeper skin layers, leading to an improved pharmacodynamic effect. In analgesic tests carried out in a pain mice model following one hour application of CBD in Weblike system with and without HSO, the number of writhing episodes was decreased from 29 in the untreated animals to 9.5 and 18.5 writhes, respectively. The results of our work open the way towards a further investigation of Weblike film forming systems containing drugs for improved dermal and transdermal treatment of various ailments.

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“…In our previous study on Weblike delivery systems, 31 P-NMR spectra suggested a reverse micellar organization of phospholipid in high ethanolic solutions [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Film Forming Systems for Delivery of Active Molecules into and across the Skin

2023

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“…However, there is a critical concentration of ethanol that may cause a destabilization due to phospholipid bilayers interdigitation [148]. Multiple studies showed the effectiveness of ethosomes for dermal drug delivery in occlusive and nonocclusive applications [141,150,151], and demonstrated their excellent ability to enhance the cutaneous permeation of drugs, including highly lipophilic and highly hydrophilic active compounds [147,[152][153][154].…”

Section: Nanovesicular Carriersmentioning

confidence: 99%

Recent Advances in Nanomaterials for Dermal and Transdermal Applications

Zoabi

Touítou

Margulis

2021

Colloids and Interfaces

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The stratum corneum, the most superficial layer of the skin, protects the body against environmental hazards and presents a highly selective barrier for the passage of drugs and cosmetic products deeper into the skin and across the skin. Nanomaterials can effectively increase the permeation of active molecules across the stratum corneum and enable their penetration into deeper skin layers, often by interacting with the skin and creating the distinct sites with elevated local concentration, acting as reservoirs. The flux of the molecules from these reservoirs can be either limited to the underlying skin layers (for topical drug and cosmeceutical delivery) or extended across all the sublayers of the epidermis to the blood vessels of the dermis (for transdermal delivery). The type of the nanocarrier and the physicochemical nature of the active substance are among the factors that determine the final skin permeation pattern and the stability of the penetrant in the cutaneous environment. The most widely employed types of nanomaterials for dermal and transdermal applications include solid lipid nanoparticles, nanovesicular carriers, microemulsions, nanoemulsions, and polymeric nanoparticles. The recent advances in the area of nanomaterial-assisted dermal and transdermal delivery are highlighted in this review.

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