Potentiometric Studies on Transition Metal Complexes of Substituted Derivative of Coumarin‐Part 1

Vyas, K. B.; Jani, G. R.; Hathi, M. V.

doi:10.1155/2009/146906

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Ligands bearing oxygen and nitrogen donors play an important role in coordination chemistry where extensive literature is available for the synthesis, structural and biological studies of metal complexes of these ligands [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . Apart from conventional donors, heterocyclic compounds played a major role as ligands in metal complexes synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, few Schiff bases of coumarin derivatives, identified as potential scaffolds for synthesis of novel biological agents. Therefore, the synthesis of novel Schiff bases from coumarin derivatives and their transition metal complexes remains a main focus of chemical and medicinal research 7,8 . These properties of Schiff bases of coumarin derivatives are due to heterocyclic r ings and substituted functional groups at appropriate positions.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Structures and Antimicrobial Activities of Novel Schiff Base Ligand and Its Metal Complexes

Adhao,

Wagh

2023

Orient. J. Chem

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A novel ligand (E)-7-hydroxy-4-methyl-8-(1-(naphthalen-1-ylimino) ethyl)-2H-chromen-2-one [HOMNIEC] was synthesized by condensation of 8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one and Naphthalen-1-amine by the reported method. The metal complexes with this ligand were synthesized by using a common new method. FTIR, 1H NMR, Mass Spectrometry and TGA techniques were used to confirm their structures. The FTIR spectral data indicate that the ligand was coordinated with the metal ions through the phenolic oxygen on coumarin moiety and nitrogen of azomethine. The ligand and complexes were examined for in vitro antimicrobial activities using broth microdilution method in DMSO medium against Escherichia Coli (MTCC 443) and Pseudomonas Aeruginosa (MTCC 1688) a gram-negative bacterial strain, Staphylococcus Aureus (MTCC 96) and Streptococcus Pyogenes (MTCC 442) a gram-positive bacterial strain, and Candida Albicans (MTCC 227), Aspergillus Clavatus (MTCC 1323) and Aspergillus Niger (MTCC 280) fungal strains. The metal complexes were found to have enhanced antimicrobial activities compare to the Schiff base [HOMNIEC] ligand. Especially, the antifungal activity of Cu(II) and Zn(II) ions complexes was found to be twofold more than the standard drug griseofulvin against C. Albicans.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Structures and Antimicrobial Activities of Novel Schiff Base Ligand and Its Metal Complexes

Adhao,

Wagh

2023

Orient. J. Chem

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“…[10] Furthermore, it is reported that such compounds can be used as photo-alignment and photocross-linking units in polymerization processes, [11] laser dyes and nonlinear and optical materials. [12] Also, transition metal complexes especially those with ligands containing chalcone moieties have been the main subject of much research work due to their stability, versatile biological activities [13,14] and potential applications in many fields such as oxidation catalysis and electrochemistry. [15] Metal complexation improves the catalytic activity of chalcones towards oxidation, reduction, hydrolysis and other transformations in organic and inorganic chemistry.…”

Section: Introductionmentioning

confidence: 99%

Metal complexes of chalcone analogue: Synthesis, characterization, DNA binding, molecular docking and antimicrobial evaluation

Atlam

El‐Nahass

Bakr

et al. 2017

Applied Organom Chemis

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A novel chalcone, namely 5-(4-(dimethylamino)phenyl)-1-(thiophen-2-yl)penta-2,4-dien-1-one, DMATP, and its complexes with nickel(II), vanadium(III), palladium(II) and platinum(II) metal ions were synthesized and characterized using a set of chemical and spectroscopic tools including elemental analysis, electrical conductance, magnetic susceptibility and spectral techniques. The interactions of the synthesized chalcone and its metal complexes with DNA were studied using steady-state absorption and emission techniques as well as viscosity and electrochemical measurements. The obtained results confirm DNA intercalation. Additionally, theoretical studies were performed for all the investigated compounds using DFT/B3LYP calculations. The optimized geometries are found to be in good agreement with the suggested experimental structures. The bond lengths, bond angles, chemical reactivity, energy components, binding energy and dipole moment were evaluated. Also, theoretical infrared intensities and thermodynamic parameters for all compounds were calculated. Molecular docking calculations show that the Ni(II) complex exhibits the highest DNA binding activity, which agrees well with the experimental results. Finally, the compounds were screened for antimicrobial activity using several microorganisms.

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Synthesis, Spectral, Thermal Studies and Antimicrobial Evaluation of Transition Metal Complexes with Novel Schiff Base Ligand

Adhao,

Wagh

2024

Orient. J. Chem

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A novel coumarin Schiff base “(E)-7-hydroxy-4-methyl-8-(1-(1-(naphthalen-2-yl) ethylimino) ethyl)-2H-chromen-2-one” [HOMNEIEC] ligand was synthesized by the condensation of “8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one” [AHMC] with “1-(naphthalen-1-yl) ethylamine” [NEA]. The transition metal (II) ions complexes with this ligand were synthesized by a common method. The synthesized ligand and metal (II) complexes were studied using spectral (1H NMR, FTIR, Mass Spectrometry) and thermal (TGA) techniques for their structures. The 1H NMR and FTIR spectra of ligand confirm the formation of azomethine bond. The FTIR spectral data validated the formation of coordinate bond through phenolic oxygen on coumarin ring and nitrogen of azomethine with the metal ions. The m/z values in mass spectrum of ligand and its metal complexes were in agreement with their theoretical values of molecular/formula weights. The TGA thermograms suggested there are of two coordinated/lattice H2O molecules in each of the complex. The ligand and metal complexes were evaluated for their in vitro antimicrobial activities using broth microdilution method using DMSO solvent/diluent against Escherichia coli and Pseudomonas aeruginosa a gram-negative bacterial strain, Staphylococcus aureus and Streptococcus pyogenes a gram-positive bacterial strain, and Candida albicans, Aspergillus clavatus and Aspergillus niger a fungal strain. The metal complexes were found to have enhanced antimicrobial activities compare to the Schiff base ligand.

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Potentiometric Studies on Transition Metal Complexes of Substituted Derivative of Coumarin‐Part 1

Cited by 4 publications

References 5 publications

Synthesis, Structures and Antimicrobial Activities of Novel Schiff Base Ligand and Its Metal Complexes

Synthesis, Structures and Antimicrobial Activities of Novel Schiff Base Ligand and Its Metal Complexes

Metal complexes of chalcone analogue: Synthesis, characterization, DNA binding, molecular docking and antimicrobial evaluation

Synthesis, Spectral, Thermal Studies and Antimicrobial Evaluation of Transition Metal Complexes with Novel Schiff Base Ligand

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