Potentiometric studies of complex equlibria of CaII, MgII and ZnII with 5-sulphosalicylic acid in cationic micelles of CTAB

Ramanaiah, Malla; Seetharam, Pondala; Balakrishna, M.; Raju, B. Rama

doi:10.1016/j.heliyon.2019.e02157

Cited by 6 publications

(4 citation statements)

References 19 publications

(18 reference statements)

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“…The typical distribution plots produced by DISPLOT [23][24][25][26][27], 5-Sulfosalicylic acid has three dissociable protons, one among three has low protonation constant value and will dissociate at a pH lower than 2.0 and unable to see due to the glass membrane electrode sensitivity, the existence of the ligand will be as LH2 -,LH 2-, and L3 -. In the same way 5-Hydroxysalicylic acid has three dissociable protons, one among the three has high protonation constant and will dissociate at a pH 12.0, this range of pH makes the glass electrode unable to detect the protonation as the sensitivity is high at the pH.…”

Section: Distribution Diagramsmentioning

confidence: 99%

AN ELECTROMETRIC METHOD FOR THE DETERMINATION OF IMPACT OF DMSO-WATER MIXTURES ON pKa VALUES OF SALICYLIC ACID DERIVATIVES

BALAKRISHNA,

NEERAJA,

KUMAR

et al. 2023

Int J App Pharm

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Objective: The main objective of this present study is to conduct an experiment to analyze the variation of protonation-deprotonation equilibria with regards to the dielectric constants of an organic medium, influence of errors on protonation constants and effect of pH on the percentage of species. Methods: The present investigation was carried out by using pH meter at a temperature of 303 K and ionic strength of 0.16 mol dm-3 in Dimethyl sulfoxide (DMSO)-water mixtures. The processing of data was done by using Gran plot titration. The advanced principles of mathematics and fuzzy logic have been employed to correlate chemical problems, known as chemometrics. To obtain best-fit chemical models, a modelling strategy such as SCPHD is used and a computer program MINIQUAD 75 is also employed for the refinement of results. Results: In the present study, we found the influence of dielectric constants of a medium Dimethyl sulfoxide (DMSO)-water on protonation constants of 5-Sulfosalicylic acid and 5-Hydroxysalicylic acid has been studied. The species distribution diagrams were presented and understood the effect of pH on the percentage of species. The obtained skewness values are ranging from 0.11-0.36 and–0.56-0.38, for 5-Sulfosalicylic acid (5-SSA) and 5-Hydroxysalicylic acid (5-HSA), respectively, which describes the distribution curves are right skewed and left skewed. The kurtosis values are ranging from 2.12-3.56, which indicates the peak of the distribution curve exhibits both platykurtic and leptokurtic pattern. The changes in the concentrations of some influential parameters such as log F, acid, alkali, volume of titrands, ligand causes variation of stability constants and the order of the effect of influential parameters on stability constants are as alkali>acid>ligand>volume of titrand>log F. Conclusion: It is observed that the significant influence of co-solvent Dimethyl sulfoxide (DMSO)-Water mixtures on the protonation constants of ligands also studied how some factors such as changes in concentrations of ligand, acid, base log F and volume of the solution have influence on the protonation constants.

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Section: Distribution Diagramsmentioning

confidence: 99%

AN ELECTROMETRIC METHOD FOR THE DETERMINATION OF IMPACT OF DMSO-WATER MIXTURES ON pKa VALUES OF SALICYLIC ACID DERIVATIVES

BALAKRISHNA,

NEERAJA,

KUMAR

et al. 2023

Int J App Pharm

Self Cite

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“…SCPHD [ 43 ], a computer program required to evaluate the correction factor in data given by free acid titrations, which accounts the errors occurred at the glass electrode during the experimentation via discrepancy in asymmetric potential, diffusion potential, liquid junction potential, alkaline error, activity coefficient, dissolved inorganic carbon (CO 2 ) at the membrane of the Ion-selective electrode. Input the data to MINIQUAD75 [ 44 ], to determine the stability of binary metal (Co II , Ni II and Cu II ) - methionine system, – log K w , correction factor [ 45 , 46 ] and acidity constants of met are set to be constant throughout the process of refinement.…”

Section: Experimental and Instrumentationmentioning

confidence: 99%

Speciation study involving mononuclear binary transition metal (CoII, NiII and CuII) complexes of L-methionine in non-ionic micellar medium

Neeraja

Bindu

2021

Heliyon

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The present work aims to evaluate the binding capacities of binary complexes of L-Methionine with transition metal ions Co II , Ni II and Cu II in Triton X 100-water mixtures, a non-ionic micellar media of different compositions (0.0–2.5% (v/v)), investigated under the experimental conditions of 0.16 mol/dm 3 ionic strength using NaNO 3 at a temperature of 303.0 ± 0.1 K Potentiometrically. The potentiometric data was assessed by Irving-Rossotti pH metric technique with the least-squares method of MINIQUAD75, a computer program. The selectivity of the best fit model obtained by continuous exhaustive chemical modelling studies and the accuracy of the results is assessed based on statistical parameters. MLH, ML and ML 2 are the identified species for the three M(Co II , Ni II and Cu II ) - Met systems. The shift in the equilibrium of binary metal-methionine complexes with variation in composition (0.0–2.5%) of the solvent can be explained by electrostatic together with non-electrostatic forces contributed by the interaction of solute with solvent.

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“…The bars represent one standard error. toxic cationic surfactant [84][85][86] and the conjugate systems of AuNWs-CTAB are proven to still contribute to toxicity to culture cells especially when the elevated concentrations of CTAB are present (50 g/ml commercial AuNWs-CTAB). With increasing the amount of AuNWs-CTAB solution, the cytotoxicity of the sample is increased caused by the nonspeci c binding tendency of CTAB to negatively charged cell surfaces by electrostatic interactions [87,88].…”

Section: Cytotoxicity Evaluation Of As-synthesised and Commercial Aunwsmentioning

confidence: 99%

Synthesis, Characterisation and Cytotoxicity of Gold Nanowires for Ultra-Sensitive Biosensor Development

Lah

Gray

Trigueros

2020

Preprint

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With the long-term goal of developing an ultra-sensitive microcantilever-based nano biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadvantages of conventional ones. Gold nanowires (AuNWs) have been used as a probe to overcome the tolerance problem that occurs in response to changes in environmental conditions. However, the cytotoxicity of AuNWs is still unclear. Here, we examined the cytotoxicity of AuNWs systems using both commercial and as-synthesised AuNWs. In vitro experiments show that commercial AuNWs with an average quoted length of 6 µm are highly toxic against Gram-negative Escherichia coli (E. coli) at 50 µg/ml. However, this toxicity is due to the presence of CTAB surfactant not by the nanostructure. Conversely, the as-synthesised AuNWs with an average length of 9.5 µm show non-cytotoxicity even at the maximum viable concentration (330µg/ml). These findings may lead to the development of potentially life-saving cytotoxicity -free nano biosensors for an early diagnostic of potential diseases.

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Potentiometric studies of complex equlibria of CaII, MgII and ZnII with 5-sulphosalicylic acid in cationic micelles of CTAB

Cited by 6 publications

References 19 publications

AN ELECTROMETRIC METHOD FOR THE DETERMINATION OF IMPACT OF DMSO-WATER MIXTURES ON pKa VALUES OF SALICYLIC ACID DERIVATIVES

AN ELECTROMETRIC METHOD FOR THE DETERMINATION OF IMPACT OF DMSO-WATER MIXTURES ON pKa VALUES OF SALICYLIC ACID DERIVATIVES

Speciation study involving mononuclear binary transition metal (CoII, NiII and CuII) complexes of L-methionine in non-ionic micellar medium

Synthesis, Characterisation and Cytotoxicity of Gold Nanowires for Ultra-Sensitive Biosensor Development

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