Potentiometric pH sensors based on chemically modified electrodes with electropolymerized metal-tetraaminophthalocyanine

Kang, Tianfang; Xie, Zhong-Yi; Tang, He; Shen, Guo‐Li; Yu, Ru‐Qin

doi:10.1016/s0039-9140(97)00124-0

Cited by 33 publications

(11 citation statements)

References 10 publications

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“…Various polymers have been considered suitable for potentimetric pH sensors [52, 53, 54, 55, 56, 57]. Potentiometric pH sensors based on linear polyethylenimine (L-PEI) and linear polypropylenimine (L-PPI) (two synthetic enzymes and biocompatible polymers) films were prepared by electropolymerization of three different monomers: ethylenediamine (EDA), 1,3-diaminopropane (1,3-DAP) and diethylenetriamine (DETA) in order to be used in clinical, dermatological and biological applications, such as in vivo analysis [53].…”

Section: Polymers and Methods Used For Ph Measurementsmentioning

confidence: 99%

State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China

Korostynska

Arshak

Gill

et al. 2007

Sensors

161

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Section: Polymers and Methods Used For Ph Measurementsmentioning

confidence: 99%

State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China

Korostynska

Arshak

Gill

et al. 2007

Sensors

161

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“…They found that tissue pH, when compared to serum pH, had the advantages of reacting earlier to changes in tissue perfusion and it could be measured with minimal invasiveness. These studies involved miniaturised glass pH sensors, whose major disadvantages lie in the difficulty of miniaturisation [11], drift [12], fragility [13] and electrode fouling [14], culminating in inaccurate measurements. Voltammetric pH sensors have recently demonstrated excellent potential both in vitro [15e17] and in vivo [18,19].…”

Section: Introductionmentioning

confidence: 99%

Physiological monitoring of tissue pH: In vitro characterisation and in vivo validation of a quinone-modified carbon paste electrode

Herdman

Breslin

Finnerty

2019

Electrochimica Acta

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The fluctuation of physiological pH from homeostatic levels has the potential to cause life threatening complications unless counteracted in a timely manner. Therefore, the development of reliable and accurate sensors for the continuous monitoring of pH is of vital importance for clinical monitoring. Herein, we describe the extensive in vitro characterisation of a quinone-modified carbon paste electrode (CPE) and its subsequent in vivo validation in the peripheral tissue of anaesthetised rats. Sensocompatibility investigations identified stable and accurate measurements in lipid (phosphatidylethanolamine; PEA) and protein (bovine serum albumin; BSA) solutions when the pH sensor was continuously cycled for nine hours in the physiological contaminants. The influence of endogenous electroactive molecules e.g., ascorbic acid and uric acid and pharmacological interferents e.g., acetaminophen and acetylsalicylic acid was deemed negligible on the pH sensitive peak. Furthermore, there was no impact of ionic strength and the quinone oxidation peak remained selective for H þ over other endogenous cations. The effect of temperature and a pseudo reference electrode (PRE) on the sensor performance have also been elucidated. The efficacy of the modified-CPE to respond to in vivo tissue pH dynamics was demonstrated using a model of peripheral ischaemia and sodium bicarbonate injections. Collectively, this body of evidence clearly support the ability of the quinone-modified CPE to continuously measure pH fluctuations under physiological conditions.

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“…For instance, the dairy industry requires pH sensing for several processes such as checking the freshness of milk, bacterial conversion of lactose to lactic acid in yogurt, cheese production, and so on . The importance of pH sensing has led to development of many types of sensors such as potentiometric sensors, electrolyte–insulator–semiconductor sensors, and fluorescence sensors. Fluorescence pH sensors are of particular interest owing to the high sensitivity, selectivity, and speed inherent to fluorescence measurements. , Moreover, nanomaterials can be used to enhance many such pH sensors by facilitating the manipulation of solubility, fluorescence intensity, and combinations of multiple beneficial components .…”

Section: Introductionmentioning

confidence: 99%

Fluorescence-Based Ratiometric Nanosensor for Selective Imaging of Cancer Cells

et al. 2019

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Herein, we report the synthesis and characterization of a nanosensor developed from a group of uniform materials based on organic salts (GUMBOS). This sensor is composed of three ionic species, namely, fluorescein, rhodamine B, and tetradecyltrihexyl phosphonium (P 66614 ) ions. Nanoparticles prepared from this three-component GUMBOS, termed nanoGUMBOS, exhibited increased fluorescence at two wavelengths with increases in pH values. The ratio of fluorescence emission corresponding to FL and RhB components of these nanoGUMBOS also changed with pH, allowing ratiometric analysis of pH through fluorescence measurements. Peak ratios were significantly different at pH 5 and pH 7, indicating potential applications of this nanomaterial as a cancer diagnostic tool. In this regard, in vitro fluorescence microscopy was employed to image cancerous and normal breast cells incubated with nanoGUMBOS. Fluorescence imaging of cancer cells showed higher uptake of these nanoGUMBOS and more pervasive fluorescence intensity in comparison with normal cells. Thus, the synthesized novel nanomaterial shows a great potential for rapid visual imaging of cancer cells.

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Potentiometric pH sensors based on chemically modified electrodes with electropolymerized metal-tetraaminophthalocyanine

Cited by 33 publications

References 10 publications

State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China

State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China

Physiological monitoring of tissue pH: In vitro characterisation and in vivo validation of a quinone-modified carbon paste electrode

Fluorescence-Based Ratiometric Nanosensor for Selective Imaging of Cancer Cells

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