Potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine

Improving the detection limits of antispasmodic drugs electrodes by using modified membrane sensors with inner solid contact

“…In previous studies we described a group of ion-exchangerbased PVC membrane electrodes, with liquid inner contact, for the selective determination of dicyclomine [1], mebeverine [2] and drotaverine [3]. The ion-exchanger incorporated in each electrode was an ion-association of the drug cation with the heteropoly anion silicotungstate, silicomolybdate, phosphotungstate or phosphmolybdate.…”

“…Previous work from our laboratory described the development of a group of conventional PVC membrane electrodes for the antispasmodic drugs dicyclomine [1], mebeverine [2] and drotaverine hydrochlorides [3]. The detection limits of these electrodes are in the range of 2 × 10 −6 -8 × 10 −6 M. These moderately high values of detection limits prohibit the use of these electrodes in determination of the drugs in real (unspiked) serum and urine samples.…”

Chemically modified carbon paste electrode for the potentiometric flow injection analysis of piribedil in pharmaceutical preparation and urine

“…The ion-exchangers piribedil silicotungstate (PD-ST), piribedil silicomolybdate (PD-SM), piribedil phosphotungstate (PD-PT) and piribedil phosphmolybdate (PD-PM) were prepared as previously described by Ibrahim [27]. The chemical compositions of these compounds were found to be PD 4 ST, PD 4 SM, PD 3 PT, and PD 3 PM as confirmed by (C, H and N) elemental analysis using automatic CHN analyzer (Perkin-Elmer model 2400).…”

“…Previous work from this laboratory described the use of the highly insoluble ion-associates formed from the reactions of heteropoly acids (silicotungstic, silicomolybdic, phosphotungstic and phosphomolybdic) with some organic cations as sensory molecules for a group of ion-selective electrodes [26,27].…”

A validated chiral HPLC method for the determination of mebeverine HCl enantiomers in pharmaceutical dosage forms and spiked rat plasma

“…They include high performance liquid chromatography (Hoogewijs and Massart, 1986;Stockis et al, 2002), on-line micellar electrokinetic chromatography-mass spectrometry (Somsen et al, 2003), high-performance thin-layer chromatography (De Schutter et al, 1985;El-Walily et al, 1991), capillary supercritical fluid chromatography-mass spectrometry (Pinkston et al, 1993), gas chromatography-mass spectrometry, and online reversed-phase liquid chromatography-gas chromatography (Kristinsson et al, 1994;Tulich et al, 1996;Kraemer et al, 2000). Other alternatives include spectrophotometry (El-Walily et al, 1991;Shama and Amin, 2004) and potentiometric flow injection analysis (Ibrahim et al, 2005).…”