Potentiometric, ESI MS and AM1d studies of lasalocid esters–silver(I) complexes

FT-IR, semi-empirical and electrochemical studies of lasalocid ester with 2, 2′-dithiodiethanol adsorbed on silver surface

“…These data This situation is comparable to that in the previously studied lasalocid esters [8][9][10][11][12][13][14][15][16][17].…”

“…In the cell membrane lasalocid exchanges metal ions against H + , leading to changes in the pH values and to an increase in osmotic pressure inside the cell, which finally leads to the cell death [1][2][3][4][5][6][7]. In our previous papers, we have reported synthesis and studies of a series of new esters of lasalocid as well as its complexes with monovalent cations by several spectroscopic and ESI-MS methods [8][9][10][11][12][13][14][15][16][17]. Inspired by the literature data [18][19][20] and our previous work with self assembled monolayers on silver and gold surfaces formed by bifunctional podands [21,22], we report in this paper on a new type of surface modified by the lasalocid ionophore.…”

New Hydrophilic Derivatives of Lasalocid and Their Complexes with Selected Metal Cations

“…Even slight structural modifications [ 8 , 9 , 10 , 11 , 12 , 13 ] of the antibiotic molecules may result in changes to the structure of the complex, which affects the ability of the ionophore to bind metal ions and transport them through the cell lipid layers. For biologically active compounds, such changes may have an impact on their antimicrobial properties [ 14 , 15 ].…”

“…So far, modifications of natural lasalocid have been focused mainly on the creation of lipophilic derivatives containing alkyl chains or aromatic rings in their structure. Much attention has also been devoted to the synthesis of derivatives containing polyether structures, such as oxaalkyl [ 10 , 20 , 21 ], hydroxyoxaalkyl [ 9 , 22 , 23 ], ethylene glycol [ 8 , 24 ] and crown ether [ 25 ], to increase the ability to form complexes of alkali metal cations and the solubility of the complex in the lipid membrane [ 19 ]. However, a good ion carrier should be characterized not only by the ease of forming stable complexes, but also by the ease of releasing complexed ions.…”