Potentiometric Determination of Clonazepam Using Carbon Paste Electrode Based on Molecular Imprinted Polymer (MIP) in Solution and in a Biological Fluid Model

Soroush, S; Maryam, Bareera

doi:10.4172/2153-2435.1000499

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…One of the electrodes is called the reference electrode (its potential remains constant), while the potential of the second (the working electrode) changes depending on the composition of the sample. The potential difference between the two electrodes then makes it possible to evaluate the composition of the sample with BZD [74–77].…”

Section: Methods Commonly Used For the Analysis Of Bzds In Biologimentioning

confidence: 99%

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Qriouet

Qmichou

Bouchoutrouch

et al. 2019

Journal of Analytical Methods in Chemistry

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The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these drugs are present in the illegal street market, leading to a lot of drug abuse amongst some addicted users, road insecurity, and suicide. Hence, it has become essential to analyze the BZDs drugs in human biological specimens for drug abuse in forensic sciences. The present review provides a summary of sample preparation techniques (solid-phase extraction and Liquid-liquid phase extraction) and the methods for the detection and quantification of BZDs molecules in the commonly used biological specimens over the ten last years which may potentially lead to better and accurate evaluation of the physiological state of a given person. The commonly used methods for the detection and quantification of BZDs include nuclear magnetic resonance (NMR), chromatography (GC-MS, HPLC, and TLC), immunoassay (ELISA, RIA, LFA, CEDEA, FPIA, and KIMS), and electroanalytical methods (voltammetry and potentiometry).

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Section: Methods Commonly Used For the Analysis Of Bzds In Biologimentioning

confidence: 99%

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Qriouet

Qmichou

Bouchoutrouch

et al. 2019

Journal of Analytical Methods in Chemistry

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Applications of Potentiometric Sensors for the Determination of Drug Molecules in Biological Samples

Özbek

Berkel

Işıldak

2020

Critical Reviews in Analytical Chemistry

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A Simply Fabricated Electrochemically Pretreated Glassy Carbon Electrode for Highly Sensitive Determination of Clonazepam by Adsorptive Cathodic Stripping Voltammetry

Khoka¹,

Samoson²,

Yodrak³

et al. 2021

J. Electrochem. Soc.

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Using a simple method, a glassy carbon electrode was electrochemically pretreated for highly sensitive determination of clonazepam. The electrochemically pretreated glassy carbon electrode was employed as an adsorbent and a working electrode for the detection of clonazepam by adsorptive cathodic stripping voltammetry. The surface morphology and electrochemical properties of the glassy carbon electrode and the electrochemically pretreated glassy carbon electrode were studied by energy dispersive X-ray spectroscopy and cyclic voltammetry. The analytical measurements of clonazepam were evaluated using adsorptive cathodic stripping voltammetry. To obtain the optimal electrochemical reduction of clonazepam by the electrochemically pretreated glassy carbon electrode, the electrochemical pretreatment process, preconcentration potential and preconcentration time were optimized. The detection of clonazepam standards under the optimal conditions produced a cathodic current response with a detection limit of 19 μg l−1, quantification limit of 63 μg l−1 and a linear range from 0.0250 to 1.50 mg l−1. The sensor exhibited excellent sensitivity (453 μA mg−1 l cm−2), and good repeatability (%RSD < 11%) and recovery (98 ± 2 to 102 ± 4%). The developed sensor was successfully utilized for the measurement of clonazepam in beverage samples.

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Potentiometric Determination of Clonazepam Using Carbon Paste Electrode Based on Molecular Imprinted Polymer (MIP) in Solution and in a Biological Fluid Model

Cited by 3 publications

References 39 publications

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Applications of Potentiometric Sensors for the Determination of Drug Molecules in Biological Samples

A Simply Fabricated Electrochemically Pretreated Glassy Carbon Electrode for Highly Sensitive Determination of Clonazepam by Adsorptive Cathodic Stripping Voltammetry

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