Potentiometric and spectroscopic evidence for co-ordination of dimethyltin(IV) to phosphate groups of DNA fragments and related ligands

Jancsó, Attila; Nagy, László; Moldrheim, Erlend; Sletten, Einar

doi:10.1039/a901322i

Cited by 75 publications

(52 citation statements)

References 46 publications

(27 reference statements)

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“…The increasing interest in organotin(IV) carboxylates of substituted benzoic acids in recent years has, to a large extent, been prompted by their new structural diversity [1] and broad therapeutic activity [2]. Information on the structure of organotin(IV) carboxylates continues and at the same time some new applications of such a high importance are being discovered which are relevant to ecological medicinal applications.…”

Section: Introductionmentioning

confidence: 99%

Structural chemistry of organotin(IV) complexes

Shahzadi

Ali

2008

JICS

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The amazing structural diversity in organotin compounds is discussed in the systems containing -O and -S donor ligands. It is demonstrated that there exist a fascinating range of structural diversity for organotin(IV) complexes, including differences in coordination number and molecular geometry. The difference in structure is correlated with the nature of tin and ligand bonded R groups. Despite the large number of different structures found in organotin(IV) carboxylates, there is limited range of coordination geometries about the Sn atom. The four coordinated Sn atom in triorganotin(IV) complexes is invariably distorted tetrahedral and five coordinated Sn is distorted trigonal bipyramidal. A large range has been observed for diorganotin carboxylate structures, where five, six and seven coordinate geometries have been reported. The Sn atom in mono-organotin has only been demonstrated to exist in distorted octahedral geometries (the single exception being a pentagonal bipyramidal geometry). In the case of organotin(IV) complexes of S donor ligands, it has been shown that there exists a rich diversity in Sn atom geometries and coordination modes of the sulfur donor ligands themselves. As in related carboxylate systems, the assignment of coordination numbers to the Sn centers in some compounds is controversial. As a general trend, it has been shown that, the overall coordination number at the Sn atom decreases with the increasing number of organic substituents at the Sn atom. This phenomenon is usually achieved by increased asymmetry in the mode of coordination of the sulfur donor ligands.

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Section: Introductionmentioning

confidence: 99%

Structural chemistry of organotin(IV) complexes

Shahzadi

Ali

2008

JICS

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“…Other fragments observed are quite intense as given in the Experimental section. Figure 2 shows the molecular structure and atomic numbering scheme of complex (2). The crystal data and Tables 2 and 3 Bordetella bronchiseptica (ATCC 4617).…”

Section: Mass Spectrometrymentioning

confidence: 99%

“…The increasing interest in organotin(IV) carboxylates of substituted benzoic acids in recent years has, to a large extent, been prompted by their new structural diversity [1] and broad therapeutic activity [2]. Research on the structure of organotin(IV) carboxylates continues and, at the same time, some new applications of high importance are being discovered which are relevant to ecological medicinal applications.…”

Section: Introductionmentioning

confidence: 99%

In vitro antitumor and antibacterial assay of organotin(IV) complexes of 2,3-methylenedioxybenzoic acid; X-ray crystal structure of [(C2H5)2Sn(C8H5O4)2]

Hussain

Hanif

Ali

et al. 2010

JICS

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New organotin(IV) compounds containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) have been synthesized with the general formula R 2 SnL 2 (R = Me, Et, n-Bu, Ph and n-Oct) and R 3 SnL (R = n-Bu). All compounds have been studied in the solution state by multinuclear NMR ( 1 H, 13 C and 119 Sn) by using the non-coordinating solvent and also in solid sate by FTIR, mass spectrometry and X-ray crystallography. Spectroscopic data have shown that methylenedioxy moiety does not coordinate with tin atom and the coordination site is actually -COO group, as is proved by X-ray structure determination. The solid state structure of compound (2) has been determined by X-ray crystallography which shows that the complex (2) has distorted octahedral geometry. These complexes have been evaluated in vitro against crown gall tumor and antibacterial activity. Interesting results were noticed during the bio-activity screenings, which proved their in vitro biological potential and possible use as drugs.

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“…1, with organotin halides in aqueous media using vibrational and NMR ( 1 H, 13 C, 15 N, 31 P and 117,119 Sn NMR, using, where appropriate, one-and two-dimensional techniques) spectroscopies (see, for example Ghys et al, 6 Jancso et al, 7 Yang et al 8 and Nafisi et al 9 ), as well as stability constant studies, 10,11 has revealed that this is not the case. Solid-state studies of isolated complexes, using NMR, 6 Mössbauer, 8 -16 and IR spectroscopies, and frozen solutions, using Mössbauer spectroscopy, similarly confirm this.…”

Section: Introductionmentioning

confidence: 96%

Semiempirical studies on the interactions of dialkyldi(aquo)tin cations, [R₂Sn(H₂O)₂]²⁺, with selected nucleotides

Cassús¹,

Machado

Wardell

2007

Applied Organom Chemis

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Potentiometric and spectroscopic evidence for co-ordination of dimethyltin(IV) to phosphate groups of DNA fragments and related ligands

Cited by 75 publications

References 46 publications

Structural chemistry of organotin(IV) complexes

Structural chemistry of organotin(IV) complexes

In vitro antitumor and antibacterial assay of organotin(IV) complexes of 2,3-methylenedioxybenzoic acid; X-ray crystal structure of [(C2H5)2Sn(C8H5O4)2]

Semiempirical studies on the interactions of dialkyldi(aquo)tin cations, [R₂Sn(H₂O)₂]²⁺, with selected nucleotides

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Potentiometric and spectroscopic evidence for co-ordination of dimethyltin(IV) to phosphate groups of DNA fragments and related ligands

Cited by 75 publications

References 46 publications

Structural chemistry of organotin(IV) complexes

Structural chemistry of organotin(IV) complexes

In vitro antitumor and antibacterial assay of organotin(IV) complexes of 2,3-methylenedioxybenzoic acid; X-ray crystal structure of [(C2H5)2Sn(C8H5O4)2]

Semiempirical studies on the interactions of dialkyldi(aquo)tin cations, [R2Sn(H2O)2]2+, with selected nucleotides

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Semiempirical studies on the interactions of dialkyldi(aquo)tin cations, [R₂Sn(H₂O)₂]²⁺, with selected nucleotides