2005
DOI: 10.1007/bf02977899
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Potentin Vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomyceteSac-charopolyspora sp. nov.

Abstract: Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

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Cited by 82 publications
(49 citation statements)
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“…Diversifi ed groups of marine actinobacteria are known to produce different types to anticancer compounds. Several kinds of cytotoxic compounds have been reported from marine actinobacteria [41][42][43][44][45][46][47][48] . The isolated compounds showed signifi cant activity against different cancer cell lines.…”
Section: Biotechnological Importance Of Marine Actinobacteriamentioning
confidence: 99%
“…Diversifi ed groups of marine actinobacteria are known to produce different types to anticancer compounds. Several kinds of cytotoxic compounds have been reported from marine actinobacteria [41][42][43][44][45][46][47][48] . The isolated compounds showed signifi cant activity against different cancer cell lines.…”
Section: Biotechnological Importance Of Marine Actinobacteriamentioning
confidence: 99%
“…derived from tunicate-originated Saccharopolyspora are quite rare, 13,14) we propose from the results of this study that new species of Actinobacteria could produce bioactive compounds comprising unique skeletal structures.…”
mentioning
confidence: 72%
“…nov., led to the isolation of two known prodigiosin analogs and undecyl prodigiosin. These compounds exhibited significant cytotoxic activities against cancer cell lines: P388, HL60, A-549, BEL-7402 and SPCA4 (Liu et al, 2005). Revathy et al (2013) studied the antioxidant and enzyme inhibitory potential of Streptomyces sp.…”
Section: Marine Bacteria and Actinomycetesmentioning
confidence: 99%