Potentiation of X-Ray Effects by Actinomycin D

D’Angio, Giulio J.; Farber, Sidney; Maddock, Charlotte L.

doi:10.1148/73.2.175

Cited by 354 publications

(114 citation statements)

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“…The relationship between the period of time from radiation to medication exposure and the severity of dermatitis is unclear. It is postulated that the recall seems to be most severe when the duration between the radiotherapy and drug exposure is short [2]. It is also unclear whether the agents carboplatin and docetaxel, which did not cause recall phenomenon in this patient, added to or augmented the reaction by the antibiotic months later.…”

Section: Discussionmentioning

confidence: 87%

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Radiation Recall Dermatitis with Cefotetan: A Case Study

Ayoola

Lee

2006

The Oncologist

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Radiation recall dermatitis (RRD) is an inflammatory skin reaction that occurs in a previously irradiated body part following drug administration. This phenomenon may occur from days to years following exposure to ionizing radiation. The case of a 54-year-old Caucasian woman who was initially treated with external-beam radiation to the right thoracic region following the diagnosis of a poorly differentiated squamous cell carcinoma of the right lung is reported. She received four cycles of consolidated chemotherapy with docetaxel and carboplatin. Four months later, she was admitted to the hospital for acute cholecystitis and was placed on cefotetan. She developed a tender, erythematous rash on the posterior region of her right thorax 48 hours later. The drug was withdrawn, supportive care was instituted, and the patient subsequently improved. RRD should be suspected in patients who develop an erythematous rash in a previously irradiated region. To our knowledge this entity has not been associated with cefotetan previously.

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Section: Discussionmentioning

confidence: 87%

“…This may occur from days to years after exposure to ionizing radiation [1]. This entity is associated with chemotherapy and was originally described with the use of actinomycin [2]. Other antineoplastic drugs have been implicated in the development of RRD.…”

Section: Introductionmentioning

confidence: 99%

Radiation Recall Dermatitis with Cefotetan: A Case Study

Ayoola

Lee

2006

The Oncologist

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“…The phenomenon in which chemotherapy drugs reactivate latent radiation effects in previously irradiated normal tissues was first reported in 1959 in children [1]. The true incidence of this condition unclear due to the limited literature, but observational studies mostly involving cutaneous reactions indicates a wide range varying between 1.8% and 11.5% [2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Radiation Recall Masquerading as an Infectious Process

Narayanan¹,

Mujtaba²,

Koay³

et al. 2017

IJRRT

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“…The first radiation recall reaction was described by D'Angio in 1959. It involved actinomycin D, which, in previously irradiated skin, produced a reaction that was identical to the reaction initially produced by the radiation 1 . Although radiation recall dermatitis is the most common radiation recall reaction, other organs-including lung, brain, muscle, and gastrointestinal tract-can also be involved [2][3][4][5][6] .…”

Section: Introductionmentioning

confidence: 98%

Radiation Recall Dermatitis with Azithromycin

Vujovic

2010

Current Oncology

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Radiation recall is a well-known phenomenon that involves the "recall" of an acute inflammatory reaction in a previously irradiated region after administration of certain drugs. The most common type of radiation recall is radiation recall dermatitis, which involves the reoccurrence of an acute inflammatory skin reaction in previously irradiated skin. Most radiation recall reactions are attributable to chemotherapeutic agents. One previously reported case of radiation recall dermatitis occurred after administration of an antibiotic. The present case report is the second of radiation recall dermatitis involving an antibiotic: azithromycin.

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Potentiation of X-Ray Effects by Actinomycin D

Cited by 354 publications

References 0 publications

Radiation Recall Dermatitis with Cefotetan: A Case Study

Radiation Recall Dermatitis with Cefotetan: A Case Study

Radiation Recall Masquerading as an Infectious Process

Radiation Recall Dermatitis with Azithromycin

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